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01.02.2009 | Parkinson's Disease and Allied Conditions - Short Communication

Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy

verfasst von: Francesca R. Buttarelli, Annapia Circella, Clelia Pellicano, Dorina Tiple, Morena Giovannelli, Carlo Colosimo, Francesco E. Pontieri

Erschienen in: Journal of Neural Transmission | Ausgabe 2/2009

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Abstract

Previous studies showed the reduction of dopamine transporter immunoreactivity (DAT-IR) in peripheral blood lymphocytes (PBL) in Parkinson’s disease. Here we report the reduction of DAT-IR in PBL in the extrapyramidal variant of multiple system atrophy. These results suggest the reduction of DAT-IR in PBL in a variety of neurodegenerative disorders, provided the presence of damage of the central dopaminergic systems. The reduction of DAT-IR in PBL in these disorders may represent a compensatory phenomenon aimed at reducing intracellular dopamine influx and, consequently, dopamine-mediated aggravation of oxidative stress in these cells.

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Titel: Dopamine transporter immunoreactivity in peripheral blood lymphocytes in multiple system atrophy
verfasst von: Francesca R. Buttarelli
Annapia Circella
Clelia Pellicano
Dorina Tiple
Morena Giovannelli
Carlo Colosimo
Francesco E. Pontieri
Publikationsdatum: 01.02.2009
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 2/2009
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0170-0

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