Background
Methods
Patient data and setup
Simulation
Regions of interest (ROIs)
Treatment planning and dose calculation
Statistical analysis
Results
Parameter | Plan+ | Plan- | \( \overline{D} \)(95%CI) | p |
---|---|---|---|---|
PTV | ||||
Coverage Index | 94.49 ± 1.08 | 95.01 ± 0.43 | −0.52(− 1.18, 0.15) | 0.112 |
D2% | 54.14 ± 0.92 | 54.60 ± 0.45 | −0.46(− 1.12, 0.19) | 0.145 |
D98% | 46.59 ± 1.92 | 47.07 ± 1.69 | −0.48(− 1.13, 0.16) | 0.124 |
Dmean | 52.46 ± 0.36 | 52.51 ± 0.31 | −0.05(− 0.19, 0.10) | 0.501 |
HI | 1.09 ± 0.02 | 1.08 ± 0.01 | 0.006(0.001,0.011) | 0.024 |
CI | 0.65 ± 0.21 | 0.65 ± 0.22 | 0(−0.009, 0.005) | 0.555 |
Skin | ||||
Dmean | 40.39 ± 3.73 | 39.89 ± 3.76 | 0.50(0.11, 0.89) | 0.018 |
V5 | 98.18 ± 1.78 | 97.64 ± 2.14 | 0.54(0.12,0.97) | 0.018 |
V10 | 94.28 ± 3.77 | 93.01 ± 4.52 | 1.27(0.16, 2.49) | 0.030 |
V20 | 85.71 ± 7.46 | 84.86 ± 7.61 | 0.85(0.17, 1.53) | 0.020 |
V30 | 77.55 ± 8.79 | 76.25 ± 8.71 | 1.30(0.21, 2.40) | 0.025 |
V40 | 64.91 ± 11.61 | 63.62 ± 11.51 | 1.29(0.15, 2.43) | 0.031 |
Left Lung | ||||
Dmean | 15.32 ± 1.627 | 15.36 ± 1.82 | −0.03(−0.42, 0.35) | 0.845 |
V5 | 61.90 ± 5.15 | 62.11 ± 4.99 | −0.21(− 1.84, 1.43) | 0.783 |
V10 | 44.11 ± 4.43 | 43.84 ± 4.90 | 0.26(− 1.14, 1.66) | 0.682 |
V20 | 29.12 ± 3.85 | 29.25 ± 4.35 | −0.14(−1.16, 0.88) | 0.767 |
V30 | 19.98 ± 4.01 | 20.19 ± 4.31 | −0.21(− 0.91, − 0.49) | 0.514 |
Right Lung | ||||
Dmean | 0.94 ± 0.26 | 0.94 ± 0.23 | −0.001(− 0.05,0.05) | 0.963 |
V5 | 20.08(14.30,38.73) | 20.56(13.37,40.21) | −0.08(− 0.37,0.20) | 0.515 |
V15 | 0(0,0.01) | 0(0,0.025) | −0.01(− 0.02,0.01) | 0.235 |
Heart | ||||
Dmean | 7.45 ± 1.55 | 7.21 ± 1.40 | 0.24(−0.09, 0.57) | 0.134 |
Dmax | 51.74 ± 7.58 | 51.64 ± 7.71 | 0.11(−0.32, 0.53) | 0.589 |
V5 | 58.64 ± 6.75 | 56.41 ± 7.87 | 2.23(−1.40,5.87) | 0.198 |
V25 | 3.60 ± 3.61 | 3.56 ± 3.63 | 0.04(−0.10,0.19) | 0.526 |
LAD | ||||
Dmean | 37.93 ± 15.14 | 38.00 ± 14.86 | −0.06(−0.73, 0.61) | 0.839 |
Dmax | 3.51 ± 3.41 | 3.45 ± 3.38 | 0.06(−0.07, 0.19) | 0.319 |
V5 | 100(98.32,100) | 100(98.14,100) | − 0.17(−5.72,5.38) | 0.948 |
V30 | 13.48(0,45.85) | 12.91(0,46.0) | 0.36(− 0.09,0.80) | 0.103 |
V40 | 1.91(0,34.55) | 1.93(0,34.63) | −0.46(−1.70,0.79) | 0.428 |
Left Vessile | ||||
Dmean | 20.65 ± 10.30 | 20.65 ± 10.38 | 0(−3.07,3.07) | 0.998 |
V5 | 72.82 ± 13.30 | 69.63 ± 16.16 | 3.19(−1.01,7.39) | 0.120 |
V23 | 5.62 ± 5.53 | 5.65 ± 5.66 | −0.03(− 0.27,0.21) | 0.770 |
Right breast | ||||
Dmean | 2.14 ± 1.13 | 2.21 ± 1.14 | −0.07(− 0.27, 0.13) | 0.448 |
D2% | 14.76 ± 10.39 | 15.52 ± 10.61 | −0.76(−2.24,0.72) | 0.275 |
V5 | 8.62 ± 6.62 | 9.32 ± 6.78 | −0.70(−2.14,0.74) | 0.299 |
Spinal cord | ||||
Dmax | 17.17 ± 5.58 | 17.53 ± 6.25 | −0.36(− 1.43,0.71) | 0.464 |
D2% | 13.03 ± 4.56 | 13.25 ± 4.56 | −0.22(− 0.75,0.31) | 0.375 |
Esophagus | ||||
Dmax | 53.60 ± 3.58 | 53.73 ± 2.83 | −0.14(−1.02,0.75) | 0.736 |
V5 | 59.22 ± 18.83 | 54.55 ± 18.17 | 4.67(−4.03,13.37) | 0.256 |
Thyroid | ||||
Dmean | 32.14 ± 3.92 | 32.27 ± 3.85 | −0.13(− 0.63,0.38) | 0.593 |
Dmax | 54.68 ± 0.75 | 54.77 ± 1.16 | −0.09(− 0.70,0.52) | 0.752 |
V5 | 99.68 ± 0.79 | 99.56 ± 0.83 | 0.12(−0.31,0.54) | 0.554 |
Larynx | ||||
Dmax | 42.62 ± 8.54 | 42.72 ± 8.29 | −0.10(−1.33,1.13) | 0.858 |
V5 | 90.05 ± 13.60 | 88.24 ± 15.09 | 1.81(−1.41,5.04) | 0.235 |
Parameter | Plan+ | Plan- | \( \overline{D} \)(95%CI) | p |
---|---|---|---|---|
PTV | ||||
Coverage Index | 94.51 ± 1.28 | 95.14 ± 0.80 | −0.63(− 1.26, 0) | 0.050 |
Dmean | 52.06 ± 0.20 | 52.18 ± 0.19 | −0.12(− 0.30, 0.06) | 0.174 |
D2% | 53.97 ± 0.31 | 54.10 ± 0.30 | −0.13(− 0.36, 0.09) | 0.208 |
D98% | 47.69 ± 1.18 | 48.07 ± 0.97 | −0.38(− 0.67, − 0.09) | 0.017 |
HI | 1.08 ± 0.01 | 1.08 ± 0.01 | 0(−0.003,0.003) | 1.000 |
CI | 0.76 ± 0.04 | 0.75 ± 0.04 | 0.01(−0.002, 0.014) | 0.140 |
Skin | ||||
Dmean | 39.05 ± 3.39 | 38.61 ± 3.19 | 0.45(0.08, 0.81) | 0.022 |
V5 | 97.87 ± 2.16 | 96.72 ± 3.19 | 1.15(0.28,2.02) | 0.015 |
V10 | 91.29 ± 4.15 | 89.46 ± 4.37 | 1.83(1.07, 2.59) | 0.000 |
V20 | 82.01 ± 6.91 | 80.14 ± 6.74 | 1.87(0.88, 2.86) | 0.002 |
V30 | 74.16 ± 9.17 | 72.92 ± 8.25 | 1.24(0.21, 2.27) | 0.023 |
V40 | 63.64 ± 9.97 | 62.99 ± 9.56 | 0.65(0.09, 1.21) | 0.028 |
Right Lung | ||||
Dmean | 14.65 ± 2.30 | 14.57 ± 2.43 | 0.07(−0.17, 0.32) | 0.508 |
V5 | 62.10 ± 11.29 | 60.70 ± 10.80 | 1.40(−0.15, 2.96) | 0.072 |
V10 | 41.97 ± 8.43 | 41.16 ± 8.64 | 0.82(− 0.21, 1.84) | 0.105 |
V20 | 26.62 ± 5.38 | 26.78 ± 6.16 | −0.16(− 0.91, 0.59) | 0.636 |
V30 | 18.65 ± 3.96 | 18.84 ± 4.42 | −0.19(− 0.69, 0.32) | 0.427 |
Left Lung | ||||
Dmean | 0.87 ± 0.26 | 0.86 ± 0.25 | 0.01(−0.01, 0.02) | 0.485 |
V5 | 0.01(0,1.12) | 0.02(0,1.15) | −0.01(− 0.05,0.03) | 0.605 |
V15 | 0 | 0 | 0 | |
Heart | ||||
Dmean | 2.79 ± 1.11 | 2.83 ± 1.05 | −0.04(−0.20, 0.12) | 0.592 |
Dmax | 17.06 ± 6.93 | 17.17 ± 7.21 | −0.11(−1.09, 0.88) | 0.815 |
V5 | 17.86 ± 12.33 | 18.36 ± 11.95 | −0.50(−2.32,1.31) | 0.546 |
V15 | 0.01(0,0.34) | 0.01(0,0.26) | −0.06(− 0.24,0.11) | 0.419 |
Liver | ||||
Dmean | 7.93 ± 2.55 | 7.90 ± 2.37 | 0.03(−0.23, 0.29) | 0.787 |
V5 | 53.01 ± 17.55 | 53.22 ± 16.90 | −0.21(−2.36,1.94) | 0.831 |
V13 | 16.57 ± 8.27 | 16.36 ± 7.38 | 0.21(− 0.90,1.32) | 0.675 |
Left breast | ||||
Dmean | 1.89 ± 1.00 | 1.91 ± 1.03 | −0.02(− 0.09, 0.05) | 0.534 |
D2% | 9.66(5.28,15.69) | 9.74(5.66,15.55) | −0.02(− 0.37,0.34) | 0.916 |
V5 | 8.02 ± 5.61 | 9.21 ± 6.44 | −1.20(−3.64,1.25) | 0.298 |
Spinal cord | ||||
Dmax | 18.91 ± 7.17 | 19.04 ± 7.54 | −0.13(− 0.82,0.56) | 0.685 |
D2% | 15.04 ± 6.63 | 15.36 ± 6.56 | −0.32(− 0.85,0.20) | 0.194 |
Esophagus | ||||
Dmax | 51.26(46.71,52.98) | 51.47(47.40,52.91) | −0.12(− 0.91,0.67) | 0.739 |
V5 | 29.65(26.91,38.75) | 30.88(24.54,35.82) | 0.64(−1.09,2.36) | 0.428 |
Thyroid | ||||
Dmean | 38.19 ± 5.35 | 38.13 ± 5.13 | 0.06(−0.26,0.39) | 0.681 |
Dmax | 54.05 ± 0.64 | 54.41 ± 0.53 | −0.35(− 0.94,0.23) | 0.206 |
V5 | 100 | 100 | 0 | |
Larynx | ||||
Dmax | 49.57(34.50,51.60) | 49.56(36.21,51.63) | −1.65(−5.35,2.04) | 0.338 |
V5 | 79.41(46.83,100) | 71.87(29.53,99.17) | 6.94(1.74,12.14) | 0.014 |
Parameter | Plan+ | Plan- | \( \overline{D} \)(95%CI) | p |
---|---|---|---|---|
PGTV | ||||
Coverage Index | 97.02 ± 1.51 | 96.37 ± 1.52 | 0.65(− 0.24, 1.54) | 0.133 |
Dmean | 46.99 ± 0.23 | 46.96 ± 0.18 | 0.03(− 0.15, 0.20) | 0.726 |
HI | 1.06 ± 0.01 | 1.07 ± 0.01 | − 0.01(− 0.01, 0) | 0.024 |
CI | 0.66 ± 0.09 | 0.66 ± 0.10 | 0.01(− 0.01, 0.03) | 0.460 |
PTV | ||||
Coverage Index | 95.64 ± 1.36 | 94.58 ± 0.69 | 1.06(0.18, 1.95) | 0.024 |
Dmean | 43.43 ± 0.53 | 43.36 ± 0.66 | 0.07(−0.12, 0.26) | 0.417 |
HI | 1.18 ± 0.02 | 1.19 ± 0.02 | −0.01(− 0.01, 0) | 0.045 |
CI | 0.76 ± 0.04 | 0.78 ± 0.04 | −0.02(− 0.03, − 0.01) | 0.001 |
Skin | ||||
Dmean | 29.88 ± 2.81 | 27.18 ± 2.68 | 2.70(2.34, 3.07) | 0.000 |
V5 | 91.28 ± 4.40 | 88.60 ± 4.26 | 2.67(1.58,3.76) | 0.000 |
V10 | 83.70 ± 6.45 | 82.34 ± 6.68 | 1.36(0.95, 1.77) | 0.000 |
V20 | 77.31 ± 8.22 | 74.57 ± 8.25 | 2.73(2.12, 3.34) | 0.000 |
V30 | 67.66 ± 7.70 | 57.09 ± 7.97 | 10.58(9.17, 11.99) | 0.000 |
V40 | 19.91 ± 9.64 | 9.91 ± 5.84 | 10.00(6.64, 13.36) | 0.000 |
Left Lung | ||||
Dmean | 7.82 ± 1.26 | 8.03 ± 1.23 | −0.21(− 0.34, −0.08) | 0.006 |
V5 | 34.86 ± 6.04 | 36.04 ± 5.29 | −1.18(−2.33, − 0.03) | 0.045 |
V10 | 25.27 ± 5.08 | 24.25 ± 4.76 | −0.98(− 1.59, − 0.37) | 0.005 |
V20 | 15.50 ± 3.49 | 15.97 ± 3.54 | −0.47(− 0.76, − 0.18) | 0.005 |
V30 | 9.36 ± 2.51 | 9.63 ± 2.54 | −0.28(− 0.49, − 0.06) | 0.019 |
Right Lung | ||||
Dmean | 0.54 ± 0.22 | 0.53 ± 0.21 | 0.01(−0.01, 0.03) | 0.423 |
V5 | 0.02(0,0.38) | 0.01(0,0.51) | −2.54(−8.22,3.13) | 0.337 |
V15 | 0 | 0 | −0.89(−2.90,1.12) | 0.343 |
Heart | ||||
Dmean | 3.59 ± 1.58 | 3.61 ± 1.51 | −0.03(− 0.19, 0.14) | 0.718 |
Dmax | 38.39 ± 8.06 | 38.15 ± 8.01 | 0.24(−0.34, 0.83) | 0.371 |
V5 | 19.72 ± 13.36 | 21.67 ± 10.71 | −1.93(−7.21,3.33) | 0.426 |
V25 | 0.44(0.04,2.39) | 0.50(0.04,2.32) | 0.02(−0.09,0.13) | 0.663 |
LAD | ||||
Dmean | 13.35 ± 7.63 | 13.66 ± 7.29 | −0.32(−0.71, 0.07) | 0.099 |
Dmax | 25.64 ± 11.03 | 25.76 ± 10.42 | −0.12(−1.17, 0.92) | 0.795 |
V5 | 93.65(68.33,100) | 93.05(64.42,100) | −2.30(−4.82,0.22) | 0.069 |
V30 | 0(0,10.01) | 0(0,10.52) | −0.05(− 0.41,0.32) | 0.786 |
V40 | 0 | 0 | 0.763(−0.96,2.49) | 0.343 |
Left Vessile | ||||
Dmean | 4.91 ± 2.16 | 4.99 ± 2.12 | −0.09(− 0.35, 0.18) | 0.482 |
V5 | 33.08 ± 1172 | 33.82 ± 11.91 | −0.75(−2.90,1.40) | 0.451 |
V23 | 0.28(0.09,5.08) | 0.35(0.09,3.88) | 0.21(−0.16,0.58) | 0.229 |
Right breast | ||||
Dmean | 1.74 ± 1.09 | 1.70 ± 1.17 | 0.04(−0.06, 0.14) | 0.410 |
D2% | 5.21(3.84,10.36) | 5.37(3.48,10.12) | −0.28(−1.43,0.87) | 0.597 |
V5 | 3.74(0.52,9.16) | 2.98(0.66,6.46) | 0.72(−0.37,1.80) | 0.17 |
Spinal cord | ||||
Dmax | 0.32 ± 0.06 | 0.31 ± 0.06 | 0.01(0,0.02) | 0.121 |
D2% | 0.29 ± 0.05 | 0.28 ± 0.05 | 0.01(0,0.02) | 0.037 |
Parameter | Plan+ | Plan- | \( \overline{D} \)(95%CI) | p |
---|---|---|---|---|
PGTV | ||||
Coverage Index | 97.78 ± 1.03 | 96.28 ± 1.44 | 1.50(0.59,2.41) | 0.004 |
Dmean | 47.04 ± 0.25 | 46.98 ± 0.25 | 0.05(− 0.-3,0.13) | 0.178 |
HI | 1.07 ± 0.01 | 1.07 ± 0.01 | −0.001(− 0.0008,-0.01) | 0.025 |
CI | 0.65 ± 0.09 | 0.65 ± 0.10 | 0(−0.20,0.15) | 0.740 |
PTV | ||||
Coverage Index | 95.74 ± 1.96 | 95.29 ± 0.95 | 0.46(−0.68,1.59) | 0.391 |
Dmean | 42.71 ± 0.66 | 42.79 ± 0.57 | −0.09(− 0.23,0.05) | 0.187 |
HI | 1.16 ± 0.03 | 1.17 ± 0.03 | −0.01(− 0.03,0) | 0.093 |
CI | 0.80 ± 0.06 | 0.82 ± 0.06 | −0.02(− 0.03,0) | 0.046 |
Skin | ||||
Dmean | 32.10 ± 1.72 | 28.85 ± 2.26 | 3.25(2.65, 3.86) | 0.000 |
V5 | 95.80 ± 3.82 | 93.86 ± 4.73 | 1.94(0.78,3.10) | 0.004 |
V10 | 91.56 ± 5.22 | 88.68 ± 5.80 | 2.88(1.71, 4.05) | 0.000 |
V20 | 84.09 ± 6.66 | 79.23 ± 7.64 | 4.86(2.82, 6.89) | 0.000 |
V30 | 73.03 ± 7.03 | 61.12 ± 8.05 | 11.91(10.09, 13.73) | 0.000 |
V40 | 20.50 ± 7.73 | 9.99 ± 5.38 | 10.51(6.87,14.14) | 0.000 |
Right Lung | ||||
Dmean | 7.97 ± 1.51 | 7.80 ± 1.45 | −0.03(−0.20, 0.14) | 0.718 |
V5 | 37.34 ± 5.29 | 37.16 ± 4.45 | 0.18(−0.99, 1.35) | 0.740 |
V10 | 24.51 ± 4.53 | 24.46 ± 4.29 | 0.05(−0.73, 0.84) | 0.881 |
V20 | 14.80 ± 3.97 | 15.20 ± 3.86 | −0.40(− 0.81, 0.01) | 0.056 |
V30 | 8.73 ± 3.65 | 8.82 ± 3.51 | −0.08(− 0.46, 0.29) | 0.629 |
Left Lung | ||||
Dmean | 0.41 ± 0.19 | 0.39 ± 0.18 | 0.02(−0.01 0.05) | 0.130 |
V5 | 0 | 0 | 0.17(−0.11,0.45) | 0.195 |
V15 | 0 | 0 | 0 | |
Heart | ||||
Dmean | 1.16 ± 0.62 | 1.15 ± 0.63 | 0.01(−0.05, 0.06) | 0.858 |
Dmax | 7.79 ± 2.94 | 7.71 ± 2.83 | 0.09(−0.28, 0.45) | 0.610 |
V5 | 0.23(0.01,2.05) | 0.14(0.01,1.46) | 0(−0.52,0.52) | 0.988 |
V15 | 0 | 0 | 0 | |
Liver | ||||
Dmean | 4.45 ± 2.84 | 4.36 ± 2.89 | 0.09(−0.11, 0.29) | 0.349 |
V5 | 26.74 ± 18.92 | 27.34 ± 19.43 | −0.59(−2.40,1.23) | 0.487 |
V13 | 11.21 ± 10.36 | 11.20 ± 10.73 | 0.01(−0.84,0.85) | 0.989 |
Left breast | ||||
Dmean | 1.08 ± 0.77 | 1.02 ± 0.70 | 0.06(0, 0.12) | 0.050 |
D2% | 4.48(2.83,8.85) | 3.21(2.70,8.52) | 0.74(0.05,1.42) | 0.038 |
V5 | 1.08(0.01,6.86) | 0.72(0,5.74) | 0.20(−0.10,0.49) | 0.167 |
Spinal cord | ||||
Dmax | 0.43 ± 0.11 | 0.41 ± 0.12 | 0.02(0,0.04) | 0.086 |
D2% | 0.39 ± 0.11 | 0.37 ± 0.10 | 0.02(0.01,0.04) | 0.014 |