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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.01.2013 | Neurophthalmology

DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices

verfasst von: Georg Michelson, Tobias Engelhorn, Simone Wärntges, Ahmed El Rafei, Joachim Hornegger, Arnd Doerfler

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 1/2013

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Abstract

Background

In glaucoma, damage of retinal ganglion cells may continue to the linked optic radiations. This study investigates the correlation of glaucoma severity indicators with parameters of axonal and myelin integrity of the optic radiations.

Methods

In this observational case–control study, 13 patients with normal-tension glaucoma, 13 patients with primary open-angle glaucoma, and seven control subjects (mean age, 57.6 ± 12.5 years) were randomly selected for diffusion tensor imaging (DTI) of the optic radiations. The results of the frequency doubling test (FDT) and the HRT-based linear discriminant functions of Burk (BLDF) and Mikelberg (MLDF) were correlated with the mean of the fractional anisotropy (FA), apparent diffusion coefficient (ADC), and radial diffusivity (RD) of the optic radiations. Multiple correlation analysis, corrected for age, stage of cerebral microangiopathy, diagnosis group, and gender was conducted at increasing thresholds of linear anisotropy (C_L) to reduce mismeasurements because of complex fiber situations.

Results

The best correlations were found for BLDF with FA at C_L threshold 0.3 (0.594, p = 0.001), with ADC at C_L 0.4 (−0.511, p = 0.005), and with RD at C_L 0.4 (−0.585, p = 0.001). MLDF correlated with FA at C_L 0.4 (0.393, p = 0.035). The FDT score correlated with FA at C_L 0 (−0.491, p = 0.007) and with RD at C_L 0 (−0.375, p = 0.045).

Conclusions

In glaucoma, DTI-derived parameters of the axonal integrity (FA, ADC) and demyelination (RD) of the optic radiation are linked to HRT-based indices of glaucoma severity and to impairment of the spatial-temporal contrast sensitivity.

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Titel: DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices
verfasst von: Georg Michelson
Tobias Engelhorn
Simone Wärntges
Ahmed El Rafei
Joachim Hornegger
Arnd Doerfler
Publikationsdatum: 01.01.2013
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 1/2013
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-011-1887-2

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DTI parameters of axonal integrity and demyelination of the optic radiation correlate with glaucoma indices

Abstract

Background

Methods

Results

Conclusions

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Abstract

Background

Methods

Results

Conclusions

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