Duloxetine withdrawal

Excerpt

A 50-year-old woman was diagnosed with mixed anxiety and depressive disorder with somatoform disorder. She received duloxetine [route not stated] at a dose of 40mg for 124 days, followed by 30mg for 48 days and 20mg for 7 days. Duloxetine was then stopped. She was also receiving zolpidem, which was changed to lorazepam. One day after discontinuation of duloxetine, she developed insomnia, tension and irritability, dizziness, dyspepsia and a crawling sensation on her scalp. Duloxetine was restarted and her symptoms disappeared over the next day.Author Comment “We applied the Naranjo's ADR Causality Assessment scale and found that it could be categorized as Probable only, with a score of six.” …