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12.07.2021 | Original Article

Dynapenia in digestive cancer outpatients: association with markers of functional and nutritional status (the FIGHTDIGO study)

verfasst von: Marine Perrier, Marie-Amelie Ordan, Coralie Barbe, Camille Mazza, Damien Botsen, Johanna Moreau, Yohann Renard, Mathilde Brasseur, Barbara Tailliere, Philippe Regnault, Eric Bertin, Olivier Bouche

Erschienen in: Supportive Care in Cancer | Ausgabe 1/2022

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Abstract

Background

The FIGHTDIGO study determined the feasibility and acceptability of handgrip strength (HGS) measurement in digestive cancer outpatients.

Purpose

To assess the relationship between muscle strength and markers of functional and nutritional status in this population.

Design

In this prospective study, a total of 201 patients were followed during 6 months and were asked to perform HGS measurement at each hospitalization. Anthropometric measurements, laboratory tests, and performance status (PS) evaluation were collected. The modified Glasgow Prognostic Score (mGPS) was calculated using CRP and albumin levels. Severe malnutrition was defined as body mass index (BMI) < 18 kg/m² in patients > 70 years old, and BMI < 16 kg/m² in those < 70 years old. Dynapenia was defined as HGS < 30 kg (men) and < 20 kg (women). Mixed logistic regressions and mixed linear regressions were performed to study factors associated with dynapenia and HGS value, respectively.

Results

A total of 879 HGS measurements were analyzed. Dynapenia occurred in 177 measurements (20.1%). BMI and HGS were significantly associated in univariate analysis (p = 0.001). In multivariate analysis, mGPS score (β = − 0.54 ± 0.31; p = 0.06) and severe malnutrition (β = − 2.8 ± 1.4; p = 0.08) tended to be associated with HGS. Dynapenia was only associated with functional status impairment in univariate analysis (n = 140/803, 17.4% in ECOG 0 and 1 versus n = 37/76, 58.7% in ECOG 2 and 3; p = 0.002).

Conclusions

Identification of dynapenia using HGS measurement may be useful to predict nutritional vulnerability in digestive cancer outpatients undergoing chemotherapy. Patients could then benefit from nutritional support, adapted physical activity programs, and early therapeutic adjustments.

Trial registration

ClinicalTrials.gov, NCT02797197.

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Titel: Dynapenia in digestive cancer outpatients: association with markers of functional and nutritional status (the FIGHTDIGO study)
verfasst von: Marine Perrier
Marie-Amelie Ordan
Coralie Barbe
Camille Mazza
Damien Botsen
Johanna Moreau
Yohann Renard
Mathilde Brasseur
Barbara Tailliere
Philippe Regnault
Eric Bertin
Olivier Bouche
Publikationsdatum: 12.07.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Supportive Care in Cancer / Ausgabe 1/2022
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-021-06416-1

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Dynapenia in digestive cancer outpatients: association with markers of functional and nutritional status (the FIGHTDIGO study)