Dysphagia and Hoarseness of Voice: What is the Diagnosis?

Excerpt

A 65-year-old female presented to the ENT OPD with dysphagia since 3 months. There was also associated history of change in voice and weight loss. She had no immunodeficiency status and HIV test was negative. There was no history of smoking or alcohol consumption. On fibreoptic laryngoscopy, there was pale growth over bilateral vocal cords, left aryepiglottic fold, and bilateral arytenoids; bilateral arytenoids were oedematous, left more than right (Fig. 1). On contrast enhanced computed tomography (CECT) of the neck and chest, there was thickening of bilateral vocal cords, asymmetric thickening of left aryepiglottic fold with obliterating of the left pyriform fossa (Fig. 2). Fibrocalcific changes were noted in the upper lobe of right lung and multiple centrilobular nodules were seen in the left upper lobe in tree-in-bud pattern. Biopsy was taken from the laryngeal lesion and the histopathology images are shown in Fig. 3. What is the diagnosis?

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