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Clinical Oral Investigations
Erschienen in: Clinical Oral Investigations 8/2016

23.11.2015 | Original Article

Early-life factors affect risk of pain and fever in infants during teething periods

verfasst von: Carolina Un Lam, Chin-Ying Stephen Hsu, Robert Yee, David Koh, Yung Seng Lee, Mary Foong-Fong Chong, Meijin Cai, Kenneth Kwek, Seang Mei Saw, Peter Gluckman, Yap Seng Chong

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2016

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Abstract

Aim

This longitudinal study aimed to investigate the prevalence of teething-related pain and fever and the early-life factors that may affect the risk of experiencing these disturbances within the first 1.5 years of life.

Materials and methods

Participants were recruited (n = 1033) through the Growing Up in Singapore Towards healthy Outcomes (GUSTO) birth cohort (n = 1237). Interviews were performed tri-monthly regarding the prevalence of teething pain and fever in children from 6 to 18 months of age. Crude and multivariable analyses were conducted using Poisson-log regression models.

Results

Prevalence rates for teething pain and fever were 35.5 and 49.9 % respectively. Multivariable Poisson regression analysis showed maternal second-hand tobacco smoke (SHS) exposure to increase the risk of both pain (mean ratio = 1.35; p = 0.006) and fever (mean ratio = 1.22; p = 0.025), whereas SHS exposure plus active smoking further increased risk of teething pain in the children (mean ratio = 1.89; p = 0.029). Delivery via Caesarean section increased risk of teething pain (mean ratio = 1.27; p = 0.033), while prenatal plasma vitamin D insufficiency lowered such a risk (mean ratio = 0.62; p = 0.012). Compared to Chinese infants, Indian babies exhibited lower risk of teething pain and fever (both p ≤ 0.001).

Conclusions

Early-life factors such as tobacco smoke exposure and vitamin insufficiency during pregnancy, ethnicity and childbirth via Caesarean section may significantly affect the child’s susceptibility to teething-related pain and fever.

Clinical relevance

Knowledge of prevalence and risk factors of teething disturbances may better equip primary caregivers and healthcare professionals to accurately detect teething-related local and/or systemic signs/symptoms and effectively facilitate tobacco cessation among pregnant women.
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Metadaten
Titel
Early-life factors affect risk of pain and fever in infants during teething periods
verfasst von
Carolina Un Lam
Chin-Ying Stephen Hsu
Robert Yee
David Koh
Yung Seng Lee
Mary Foong-Fong Chong
Meijin Cai
Kenneth Kwek
Seang Mei Saw
Peter Gluckman
Yap Seng Chong
Publikationsdatum
23.11.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Clinical Oral Investigations / Ausgabe 8/2016
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-015-1658-2

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