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01.09.2011 | Original Article—Alimentary Tract

Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn’s disease

verfasst von: Jun Miyoshi, Tomoharu Yajima, Susumu Okamoto, Katsuyoshi Matsuoka, Nagamu Inoue, Tadakazu Hisamatsu, Katsuyoshi Shimamura, Atsushi Nakazawa, Takanori Kanai, Haruhiko Ogata, Yasushi Iwao, Makio Mukai, Toshifumi Hibi

Erschienen in: Journal of Gastroenterology | Ausgabe 9/2011

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Abstract

Background

Host–intestinal microbial interaction plays an important role in the pathogenesis of inflammatory bowel diseases (IBDs). The surface molecules of the intestinal epithelium act as receptors for bacterial adhesion and regulate the intestinal bacteria. Some known receptors are the mucosal blood type antigens, which are regulated by the fucosyltransferase2 (FUT2) gene, and individuals who express these antigens in the gastrointestinal tract are called secretors. Recent research has revealed that the FUT2 gene is associated with Crohn’s disease (CD) in western populations.

Methods

To clarify the contribution of mucosal blood type antigens in IBD, we determined the incidence of five previously reported single-nucleotide polymorphisms of the FUT2 gene in Japanese patients. We also used immunohistochemistry to investigate the antigen expression in mucosal specimens from IBD patients and animal models.

Results

Genetic analysis revealed that all of the patients with colonic CD were secretors, whereas the incidence of secretors was 80, 80, 67, and 80%, respectively, for the control, ileocolonic CD, ileal CD, and ulcerative colitis groups (P = 0.036). Abnormal expression of blood type antigens was observed only in colonic CD. Interleukin-10^−/− mice, but not dextran sulfate sodium colitis mice, had enhanced colonic expression of blood type antigens, and the expression of these antigens preceded the development of colitis in the interleukin-10^−/− mice.

Conclusions

FUT2 secretor status was associated with colonic-type CD. This finding, taken together with the immunohistochemistry data, suggests that the abnormal expression of blood type antigens in the colon may be a unique and essential factor for colonic CD.

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Titel: Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn’s disease
verfasst von: Jun Miyoshi
Tomoharu Yajima
Susumu Okamoto
Katsuyoshi Matsuoka
Nagamu Inoue
Tadakazu Hisamatsu
Katsuyoshi Shimamura
Atsushi Nakazawa
Takanori Kanai
Haruhiko Ogata
Yasushi Iwao
Makio Mukai
Toshifumi Hibi
Publikationsdatum: 01.09.2011
Verlag: Springer Japan
Erschienen in: Journal of Gastroenterology / Ausgabe 9/2011
Print ISSN: 0944-1174
Elektronische ISSN: 1435-5922
DOI: https://doi.org/10.1007/s00535-011-0425-7

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Ectopic expression of blood type antigens in inflamed mucosa with higher incidence of FUT2 secretor status in colonic Crohn’s disease