Skip to main content
Erschienen in: European Journal of Applied Physiology 8/2014

01.08.2014 | Original Article

Effect of acute normobaric hypoxia on the ventilatory threshold

verfasst von: Carla A. Gallagher, Mark E. T. Willems, Mark P. Lewis, Stephen D. Myers

Erschienen in: European Journal of Applied Physiology | Ausgabe 8/2014

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study investigated the response of the ventilatory threshold (VT) to acute normobaric hypoxia and compared the agreement between software-based algorithms which use automatic detection to identify the VT. Results were used to examine whether the VT can be used as a physiological parameter to prescribe and monitor exercise intensity in hypoxic exercise training programs.

Methods

Fourteen untrained individuals (7 women, 7 men; age 22 ± 2 years, \(\dot{V}\)O2peak 46 ± 7 mL kg−1 min−1) completed five identical graded exercise tests (randomized order) on a cycle ergometer to measure VT at sea-level (SL) and in response to four normobaric hypoxic conditions (FIO2: 0.185, 0.165, 0.142, 0.125) equivalent to 1,000, 2,000, 3,000 and 4,000 m. Data were analyzed using a one-way analysis of variance (ANOVA) with repeated measures.

Results

The VT was similar across all conditions (SL = 1.98 ± 0.46, 1,000 m = 2.03 ± 0.61, 2,000 m = 2.27 ± 0.62, 3,000 m = 1.84 ± 0.50, 4,000 m = 2.29 ± 0.58 L min−1) for all algorithms used despite a reduction in arterial oxygen saturation at 3,000 (P ≤ 0.01) and 4,000 m (P ≤ 0.01) compared with SL values.

Conclusion

The VT appears to be a suitable physiological parameter for exercise prescription in normobaric hypoxia up to an altitude of 4,000 m.
Literatur
Zurück zum Zitat Amann M, Kayser B (2009) Nervous system function during exercise in hypoxia. High Alt Med Biol 10(2):149–164PubMedCrossRef Amann M, Kayser B (2009) Nervous system function during exercise in hypoxia. High Alt Med Biol 10(2):149–164PubMedCrossRef
Zurück zum Zitat Amann M, Subudhi AW, Foster C (2006) Predictive validity of ventilatory and lactate thresholds for cycling time trial performance. Scand J Med Sci Sports 16(1):27–34PubMedCrossRef Amann M, Subudhi AW, Foster C (2006) Predictive validity of ventilatory and lactate thresholds for cycling time trial performance. Scand J Med Sci Sports 16(1):27–34PubMedCrossRef
Zurück zum Zitat Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60(6):2020–2027PubMed Beaver WL, Wasserman K, Whipp BJ (1986) A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 60(6):2020–2027PubMed
Zurück zum Zitat Benoit H, Busso T, Castells J, Geyssant A, Denis C (2003) Decrease in peak heart rate with acute hypoxia in relation to sea level VO2max. Eur J Appl Physiol 90(5–6):514–519PubMedCrossRef Benoit H, Busso T, Castells J, Geyssant A, Denis C (2003) Decrease in peak heart rate with acute hypoxia in relation to sea level VO2max. Eur J Appl Physiol 90(5–6):514–519PubMedCrossRef
Zurück zum Zitat Bompa TO, Haff GG (2009) Periodisation: theory and methodology of training, 5th edn. Human Kinetics, Leeds Bompa TO, Haff GG (2009) Periodisation: theory and methodology of training, 5th edn. Human Kinetics, Leeds
Zurück zum Zitat Borg GAV (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377–381PubMedCrossRef Borg GAV (1982) Psychophysical bases of perceived exertion. Med Sci Sports Exerc 14(5):377–381PubMedCrossRef
Zurück zum Zitat Bosquet L, Leger L, Legros P (2002) Methods to determine aerobic endurance. Sports Med 32(11):675–700PubMedCrossRef Bosquet L, Leger L, Legros P (2002) Methods to determine aerobic endurance. Sports Med 32(11):675–700PubMedCrossRef
Zurück zum Zitat Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD, Saltin B (2003) Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284(2):R291–R303PubMed Calbet JA, Boushel R, Radegran G, Sondergaard H, Wagner PD, Saltin B (2003) Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284(2):R291–R303PubMed
Zurück zum Zitat Carter H, Jones AM, Doust JH (1999) Effect of six weeks of endurance training on the lactate minimum speed. J Sports Sci 17:957–967PubMedCrossRef Carter H, Jones AM, Doust JH (1999) Effect of six weeks of endurance training on the lactate minimum speed. J Sports Sci 17:957–967PubMedCrossRef
Zurück zum Zitat Cerretelli P (1980) Gas exchange at high altitude. In: West JB (ed) Pulmonary gas exchange, vol 1. Academic Press, New York, pp 97–147 Cerretelli P (1980) Gas exchange at high altitude. In: West JB (ed) Pulmonary gas exchange, vol 1. Academic Press, New York, pp 97–147
Zurück zum Zitat Chapman RF, Emery M, Stager JM (1999) Degree of arterial desaturation in normoxia influences VO2max decline in mild hypoxia. Med Sci Sports Exerc 31(5):658–663PubMedCrossRef Chapman RF, Emery M, Stager JM (1999) Degree of arterial desaturation in normoxia influences VO2max decline in mild hypoxia. Med Sci Sports Exerc 31(5):658–663PubMedCrossRef
Zurück zum Zitat Cheng B, Kuipers H, Snyder AC, Keizer HA, Jeukendrup A, Hesselink M (1992) A new approach for the determination of ventilatory and lactate thresholds. Int J Sports Med 13(7):518–522PubMedCrossRef Cheng B, Kuipers H, Snyder AC, Keizer HA, Jeukendrup A, Hesselink M (1992) A new approach for the determination of ventilatory and lactate thresholds. Int J Sports Med 13(7):518–522PubMedCrossRef
Zurück zum Zitat Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Routledge, New York Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Routledge, New York
Zurück zum Zitat Davis JA (1985) Anaerobic threshold—review of the concept and directions for future-research. Med Sci Sports Exerc 17(1):6–18PubMed Davis JA (1985) Anaerobic threshold—review of the concept and directions for future-research. Med Sci Sports Exerc 17(1):6–18PubMed
Zurück zum Zitat Dickstein K, Barvik S, Aarsland T, Snapinn S, Millerhagen J (1990) Validation of a computerised technique for detection of the gas exchange anaerobic threshold in cardiac disease. Am J Cardiol 66:1363–1367PubMedCrossRef Dickstein K, Barvik S, Aarsland T, Snapinn S, Millerhagen J (1990) Validation of a computerised technique for detection of the gas exchange anaerobic threshold in cardiac disease. Am J Cardiol 66:1363–1367PubMedCrossRef
Zurück zum Zitat Ekkekakis P, Lind E, Hall EE, Petruzzello SJ (2008) Do regression-based computer algorithms for determining the ventilatory threshold agree? J Sports Sci 26(9):967–976PubMedCrossRef Ekkekakis P, Lind E, Hall EE, Petruzzello SJ (2008) Do regression-based computer algorithms for determining the ventilatory threshold agree? J Sports Sci 26(9):967–976PubMedCrossRef
Zurück zum Zitat Ferretti G, Moia C, Thomet JM, Kayser B (1997) The decrease of maximal oxygen consumption during hypoxia in man: a mirror image of the oxygen equilibrium curve. J Physiol 498(1):231–237PubMedCentralPubMed Ferretti G, Moia C, Thomet JM, Kayser B (1997) The decrease of maximal oxygen consumption during hypoxia in man: a mirror image of the oxygen equilibrium curve. J Physiol 498(1):231–237PubMedCentralPubMed
Zurück zum Zitat Field A (2005) Discovering statistics using SPSS, 2nd edn. Sage, London, p 294 Field A (2005) Discovering statistics using SPSS, 2nd edn. Sage, London, p 294
Zurück zum Zitat Friedmann B, Bauer T, Menold E, Bartsch P (2004) Exercise with the intensity of the individual anaerobic threshold in acute hypoxia. Med Sci Sports Exerc 36(10):1737–1742PubMedCrossRef Friedmann B, Bauer T, Menold E, Bartsch P (2004) Exercise with the intensity of the individual anaerobic threshold in acute hypoxia. Med Sci Sports Exerc 36(10):1737–1742PubMedCrossRef
Zurück zum Zitat Friedmann B, Frese F, Menold E, Bartsch P (2005) Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia. Int J Sports Med 26(7):531–536PubMedCrossRef Friedmann B, Frese F, Menold E, Bartsch P (2005) Individual variation in the reduction of heart rate and performance at lactate thresholds in acute normobaric hypoxia. Int J Sports Med 26(7):531–536PubMedCrossRef
Zurück zum Zitat Fukuoka Y, Endo M, Oishi Y, Ikegami H (2003) Chemoreflex drive and the dynamics of ventilation and gas exchange during exercise at hypoxia. Am J Respir Crit Care Med 168(9):1115–1122PubMedCrossRef Fukuoka Y, Endo M, Oishi Y, Ikegami H (2003) Chemoreflex drive and the dynamics of ventilation and gas exchange during exercise at hypoxia. Am J Respir Crit Care Med 168(9):1115–1122PubMedCrossRef
Zurück zum Zitat Gaskill SE, Ruby BC, Walker AJ, Sanchez OA, Serfass RC, Leon AS (2001) Validity and reliability of combining three methods to determine ventilatory threshold. Med Sci Sports Exerc 33:1841–1848PubMedCrossRef Gaskill SE, Ruby BC, Walker AJ, Sanchez OA, Serfass RC, Leon AS (2001) Validity and reliability of combining three methods to determine ventilatory threshold. Med Sci Sports Exerc 33:1841–1848PubMedCrossRef
Zurück zum Zitat Gore CJ, Hahn AG, Scroop GC, Watson DB, Norton KI, Wood RJ et al (1996) Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude. J Appl Physiol 80(6):2204–2210PubMed Gore CJ, Hahn AG, Scroop GC, Watson DB, Norton KI, Wood RJ et al (1996) Increased arterial desaturation in trained cyclists during maximal exercise at 580 m altitude. J Appl Physiol 80(6):2204–2210PubMed
Zurück zum Zitat Haufe S, Wiesner S, Engeli S, Luft FC, Jordan J (2008) Influences of normobaric hypoxia training on metabolic risk markers in human subjects. Med Sci Sports Exerc 40(11):1939–1944PubMedCrossRef Haufe S, Wiesner S, Engeli S, Luft FC, Jordan J (2008) Influences of normobaric hypoxia training on metabolic risk markers in human subjects. Med Sci Sports Exerc 40(11):1939–1944PubMedCrossRef
Zurück zum Zitat Hughson RL, Green HJ, Sharratt MT (1995) Gas-exchange, blood lactate, and plasma-catecholamines during incremental exercise in hypoxia and normoxia. J Appl Physiol 79(4):1134–1141PubMed Hughson RL, Green HJ, Sharratt MT (1995) Gas-exchange, blood lactate, and plasma-catecholamines during incremental exercise in hypoxia and normoxia. J Appl Physiol 79(4):1134–1141PubMed
Zurück zum Zitat Jones AM, Carter H (2000) The effect of endurance training on parameters of aerobic fitness. Sports Med 29(6):373–386PubMedCrossRef Jones AM, Carter H (2000) The effect of endurance training on parameters of aerobic fitness. Sports Med 29(6):373–386PubMedCrossRef
Zurück zum Zitat Jones RH, Molitoris BA (1984) A statistical method for determining the breakpoint of two lines. Anal Biochem 141(1):287–290PubMedCrossRef Jones RH, Molitoris BA (1984) A statistical method for determining the breakpoint of two lines. Anal Biochem 141(1):287–290PubMedCrossRef
Zurück zum Zitat Kent M (2007) The Oxford dictionary of sports science and medicine, 3rd edn. Oxford University Press, Oxford Kent M (2007) The Oxford dictionary of sports science and medicine, 3rd edn. Oxford University Press, Oxford
Zurück zum Zitat Keppel G (1983) Design and analysis: a researchers handbook. Prentice Hall, London Keppel G (1983) Design and analysis: a researchers handbook. Prentice Hall, London
Zurück zum Zitat Lawler J, Powers SK, Thompson D (1988) Linear relationship between Vo2 max and Vo2 max decrement during exposure to acute-hypoxia. J Appl Physiol 64(4):1486–1492PubMed Lawler J, Powers SK, Thompson D (1988) Linear relationship between Vo2 max and Vo2 max decrement during exposure to acute-hypoxia. J Appl Physiol 64(4):1486–1492PubMed
Zurück zum Zitat Lucia A, Hoyos J, Perez M, Santalla A, Earnest CP, Chicharro JL (2004) Which laboratory variable is related with time trial performance time in the Tour de France? Br J Sports Med 38(5):636–640PubMedCentralPubMedCrossRef Lucia A, Hoyos J, Perez M, Santalla A, Earnest CP, Chicharro JL (2004) Which laboratory variable is related with time trial performance time in the Tour de France? Br J Sports Med 38(5):636–640PubMedCentralPubMedCrossRef
Zurück zum Zitat Mateika JH, Duffin J (1994) The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia. Eur J Appl Physiol 69(2):110–118CrossRef Mateika JH, Duffin J (1994) The ventilation, lactate and electromyographic thresholds during incremental exercise tests in normoxia, hypoxia and hyperoxia. Eur J Appl Physiol 69(2):110–118CrossRef
Zurück zum Zitat Mazzeo RS, Bender PR, Brooks GA, Butterfield GE, Groves BM, Sutton JR et al (1991) Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 261(4):E419–E424PubMed Mazzeo RS, Bender PR, Brooks GA, Butterfield GE, Groves BM, Sutton JR et al (1991) Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure. Am J Physiol 261(4):E419–E424PubMed
Zurück zum Zitat Netzer NC, Chytra R, Kupper T (2008) Low intense physical exercise in normobaric hypoxia leads to more weight loss in obese people than low intense physical exercise in normobaric sham hypoxia. Sleep Breath 12(2):129–134PubMedCentralPubMedCrossRef Netzer NC, Chytra R, Kupper T (2008) Low intense physical exercise in normobaric hypoxia leads to more weight loss in obese people than low intense physical exercise in normobaric sham hypoxia. Sleep Breath 12(2):129–134PubMedCentralPubMedCrossRef
Zurück zum Zitat Noonan V, Dean E (2000) Submaximal exercise testing: clinical application and interpretation. Phys Ther 80(8):782–807PubMed Noonan V, Dean E (2000) Submaximal exercise testing: clinical application and interpretation. Phys Ther 80(8):782–807PubMed
Zurück zum Zitat Orr GW, Green HJ, Hughson RL, Bennett GW (1982) A computer linear regression model to determine ventilatory anaerobic threshold. J Appl Physiol: Respir Environ Exerc Physiol 52(5):1349–1352 Orr GW, Green HJ, Hughson RL, Bennett GW (1982) A computer linear regression model to determine ventilatory anaerobic threshold. J Appl Physiol: Respir Environ Exerc Physiol 52(5):1349–1352
Zurück zum Zitat Overgaard M, Rasmussen P, Bohm AM, Seifert T, Brassard P, Zaar M et al (2012) Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain. FASEB J 26(7):3012–3020PubMedCrossRef Overgaard M, Rasmussen P, Bohm AM, Seifert T, Brassard P, Zaar M et al (2012) Hypoxia and exercise provoke both lactate release and lactate oxidation by the human brain. FASEB J 26(7):3012–3020PubMedCrossRef
Zurück zum Zitat Ozcelik O, Kelestimur H (2004) Effects of acute hypoxia on the estimation of lactate threshold from ventilatory gas exchange indices during an incremental exercise test. Physiol Res 53(6):653–659PubMed Ozcelik O, Kelestimur H (2004) Effects of acute hypoxia on the estimation of lactate threshold from ventilatory gas exchange indices during an incremental exercise test. Physiol Res 53(6):653–659PubMed
Zurück zum Zitat Quintero P, Milagro FI, Campion J, Martinez JA (2010) Impact of oxygen availability on body weight management. Med Hypotheses 74(5):901–907PubMedCrossRef Quintero P, Milagro FI, Campion J, Martinez JA (2010) Impact of oxygen availability on body weight management. Med Hypotheses 74(5):901–907PubMedCrossRef
Zurück zum Zitat Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, Hinghofer-Szalkay H et al (2000) Exercise exacerbates acute mountain sickness at simulated high altitude. J Appl Physiol 88(2):581–585PubMed Roach RC, Maes D, Sandoval D, Robergs RA, Icenogle M, Hinghofer-Szalkay H et al (2000) Exercise exacerbates acute mountain sickness at simulated high altitude. J Appl Physiol 88(2):581–585PubMed
Zurück zum Zitat Rosenthal R, Rosnow RL, Rubin DB (2000) Contrasts and effect sizes in behavioral research: a correlational approach. Cambridge University Press, New York, p 32 Rosenthal R, Rosnow RL, Rubin DB (2000) Contrasts and effect sizes in behavioral research: a correlational approach. Cambridge University Press, New York, p 32
Zurück zum Zitat Santos EL, Giannella-Neto A (2004) Comparison of computerized methods for detecting the ventilatory thresholds. Eur J Appl Physiol 93(3):315–324PubMedCrossRef Santos EL, Giannella-Neto A (2004) Comparison of computerized methods for detecting the ventilatory thresholds. Eur J Appl Physiol 93(3):315–324PubMedCrossRef
Zurück zum Zitat Stenberg J, Ekblom B, Messin R (1966) Hemodynamic response to work at simulated altitude, 4,000 m. J Appl Physiol 21(5):1589–1594PubMed Stenberg J, Ekblom B, Messin R (1966) Hemodynamic response to work at simulated altitude, 4,000 m. J Appl Physiol 21(5):1589–1594PubMed
Zurück zum Zitat Subudhi AW, Jacobs KA, Hagobian TA, Fattor JA, Muza SR, Fulco CS et al (2006) Changes in ventilatory threshold at high altitude: effect of antioxidants. Med Sci Sports Exerc 38(8):1425–1431PubMedCrossRef Subudhi AW, Jacobs KA, Hagobian TA, Fattor JA, Muza SR, Fulco CS et al (2006) Changes in ventilatory threshold at high altitude: effect of antioxidants. Med Sci Sports Exerc 38(8):1425–1431PubMedCrossRef
Zurück zum Zitat Sue DY, Wasserman K, Moricca RB, Casaburi R (1988) Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease: use of the V-slope method for anaerobic threshold determination. Chest 94(5):931–938PubMedCrossRef Sue DY, Wasserman K, Moricca RB, Casaburi R (1988) Metabolic acidosis during exercise in patients with chronic obstructive pulmonary disease: use of the V-slope method for anaerobic threshold determination. Chest 94(5):931–938PubMedCrossRef
Zurück zum Zitat Wasserman K, McIlroy MB (1964) Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. American J Cardiol 14:844–852CrossRef Wasserman K, McIlroy MB (1964) Detecting the threshold of anaerobic metabolism in cardiac patients during exercise. American J Cardiol 14:844–852CrossRef
Zurück zum Zitat Wehrlin JP, Hallen J (2006) Linear decrease in VO2max and performance with increasing altitude in endurance athletes. Eur J Appl Physiol 96(4):404–412PubMedCrossRef Wehrlin JP, Hallen J (2006) Linear decrease in VO2max and performance with increasing altitude in endurance athletes. Eur J Appl Physiol 96(4):404–412PubMedCrossRef
Zurück zum Zitat Wells C, Pate R (1988) Training and performance of prolonged exercise. Perspect Exerc Sci Sports Med 1:357–391 Wells C, Pate R (1988) Training and performance of prolonged exercise. Perspect Exerc Sci Sports Med 1:357–391
Zurück zum Zitat Weltman A, Seip RL, Snead D, Weltman JY, Haskvitz EM, Evans WS et al (1992) Exercise training at and above the lactate threshold in previously untrained women. Int J Sports Med 13(3):257–263PubMedCrossRef Weltman A, Seip RL, Snead D, Weltman JY, Haskvitz EM, Evans WS et al (1992) Exercise training at and above the lactate threshold in previously untrained women. Int J Sports Med 13(3):257–263PubMedCrossRef
Zurück zum Zitat Yeh MP, Gardner RM, Adams TD, Yanowitz FG, Crapo RO (1983) Anaerobic threshold: problems of determination and validation. J Appl Physiol 55(4):1178–1186PubMed Yeh MP, Gardner RM, Adams TD, Yanowitz FG, Crapo RO (1983) Anaerobic threshold: problems of determination and validation. J Appl Physiol 55(4):1178–1186PubMed
Metadaten
Titel
Effect of acute normobaric hypoxia on the ventilatory threshold
verfasst von
Carla A. Gallagher
Mark E. T. Willems
Mark P. Lewis
Stephen D. Myers
Publikationsdatum
01.08.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 8/2014
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-014-2882-1

Weitere Artikel der Ausgabe 8/2014

European Journal of Applied Physiology 8/2014 Zur Ausgabe

Neu im Fachgebiet Arbeitsmedizin

Elterliches Belastungserleben, Unaufmerksamkeits‑/Hyperaktivitätssymptome und elternberichtete ADHS bei Kindern und Jugendlichen: Ergebnisse aus der KiGGS-Studie

Open Access ADHS Leitthema

Die Aufmerksamkeitsdefizit‑/Hyperaktivitätsstörung (ADHS) ist eine der häufigsten psychischen Störungen im Kindes- und Jugendalter [ 1 ]. In Deutschland beträgt die Prävalenz einer elternberichteten ADHS-Diagnose bei Kindern und Jugendlichen 4,4 % …

Substanzkonsum und Nutzung von sozialen Medien, Computerspielen und Glücksspielen unter Auszubildenden an beruflichen Schulen

Open Access Leitthema

Die Begrenzung von Schäden durch Substanzkonsum und andere abhängige Verhaltensweisen von Jugendlichen und jungen Erwachsenen ist ein wichtiges Anliegen der öffentlichen Gesundheit. Der Übergang von der Adoleszenz zum jungen Erwachsenenalter ist …

Berufsbelastung und Stressbewältigung von weiblichen und männlichen Auszubildenden

Leitthema

In der Öffentlichkeit wird die berufliche Ausbildung oftmals unter ökonomischen Gesichtspunkten diskutiert: Mit den geburtenstarken Jahrgängen gehen erfahrene Fachkräfte in Rente und von nachfolgenden Generationen rücken zu wenige Arbeitskräfte …

Rauschtrinken in der frühen Adoleszenz

COVID-19 Leitthema

Alkohol ist in Deutschland die mit Abstand am häufigsten konsumierte psychoaktive Substanz. Mehr als 2 Drittel aller Erwachsenen im Alter von 18 bis 64 Jahren (70,5 %) hat 2021 in den letzten 30 Tagen Alkohol konsumiert [ 1 ]. Von diesen …