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Sport Sciences for Health

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15.03.2019 | Review Article

Effect of BCAA supplementation on central fatigue, energy metabolism substrate and muscle damage to the exercise: a systematic review with meta-analysis

verfasst von: Razie Hormoznejad, Ahmad Zare Javid, Anahita Mansoori

Erschienen in: Sport Sciences for Health | Ausgabe 2/2019

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Abstract

Background and aims: Current state of evidence recommends beneficial effects of branched chain amino acids (BCAAs) on exercise performance; however, randomized controlled trials (RCTs) of BCAA supplementation yield discordant results. The objective of this study was to clarify the effects of BCAA supplementation in exercise through meta-analysis of all relevant RCTs.

Methods: A comprehensive search of PubMed, Embase, ISI web of science, and the Cochrane library has been conducted from inception to September 2016. This meta-analysis includes 31 primary trials of the effect of BCAA supplementation on central fatigue, fatigue substances (lactate and ammonia), energy metabolites (glucose and free fatty acids) and, muscle damage substances (LDH and CK). The estimates were either obtained from a fixed-effects model or a random-effects model. The studies’ heterogeneity was calculated by Cochrane’s test and I² index.

Results: BCAA had no effect on central fatigue (SMD − 0.31, 95% CI − 0.72 to 0.09; p = 0.1; heterogeneity I² = 0%, p = 0.9). However, a significant reduction was detected in the lactate levels (WMD − 0.16, 95% CI − 0.26 to − 0.53; p = 0.003; heterogeneity I² = 47.9%, p = 0.023). Moreover, BCAA supplementation had beneficial effects on ammonia, glucose, FFA, and CK, but had no effects on LDH.

Conclusion: BCAA supplementation did not have any effect on the feeling of fatigue; however, it led to a favorable effect on fatigue substances, energy metabolites and muscle soreness substances. Therefore, it can be concluded that the ingestion of the BCAA can play a helpful role in the enhancement of the exercise performance.

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Titel: Effect of BCAA supplementation on central fatigue, energy metabolism substrate and muscle damage to the exercise: a systematic review with meta-analysis
verfasst von: Razie Hormoznejad
Ahmad Zare Javid
Anahita Mansoori
Publikationsdatum: 15.03.2019
Verlag: Springer Milan
Erschienen in: Sport Sciences for Health / Ausgabe 2/2019
Print ISSN: 1824-7490
Elektronische ISSN: 1825-1234
DOI: https://doi.org/10.1007/s11332-019-00542-4

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