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Archives of Dermatological Research

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13.02.2018 | Original Paper

Effect of Dickkopf1 on the senescence of melanocytes: in vitro study

verfasst von: Seema Rani, Rakhee Chauhan, Davinder Parsad, Ravinder Kumar

Erschienen in: Archives of Dermatological Research | Ausgabe 4/2018

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Abstract

Fibroblasts secrete several growth factors which are important for the regulation of skin pigmentation. Dickkopf1 (DKK1) is also secreted by fibroblasts which inhibit the growth and function of melanocytes. Therefore, the study was designed to check the role of DKK1 in vitiligo pathogenesis. This study confirmed the higher expression of DKK1 in lesional skin of vitiligo patients. In vitro effect of DKK1 on cultured melanocytes revealed decrease in the melanocytes proliferation and pigmentation. In vitro effect of DKK1 was then checked on the melanocytes senescence and found that DKK1 induced senescence in the treated melanocytes. Expression of senescence markers was significantly higher in DKK1 treated melanocytes. This study suggests that higher expression of DKK1 in the dermis induced senescence in melanocytes that may lead to hypopigmentation and play role in vitiligo pathogenesis.

Andl T, Reddy S, Gaddapara T, Millar SE (2002) Wnt signals are required for the initiation of hair follicle development. Dev Cell 2:643–653CrossRefPubMed

Bastonini E, Kovacs D, Picardo M (2016) Skin pigmentation and pigmentary disorders: focus on epidermal/dermal cross-talk. Ann Dermatol 28(3):279–289CrossRefPubMedPubMedCentral

Cardinali G, Kovacs D, Giglio MD, Cota C, Aspite N et al (2009) A kindred with familial progressive hyperpigmentation-like disorder: implication of fibroblast-derived growth factors in pigmentation. Eur J Dermatol 19:469–473PubMed

Duval C, Cohen C, Chagnoleau C, Flouret V, Bourreau E et al (2014) Key regulatory role of dermal fibroblasts in pigmentation as demonstrated using a reconstructed skin model: impact of photo-aging. PLoS One 9(12):e114182CrossRefPubMedPubMedCentral

Glinka A, Wu W, Delius H, Monaghan AP, Blumenstock C, Niehrs C (1998) Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nat 391:357–362CrossRef

Ito S (2003) A chemist’s view of melanogenesis. Pigment Cell Res 16:230–236CrossRefPubMed

Koch S, Nava P, Addis C, Kim W, Denning TL, Li L, Parkos CA, Nusrat A (2011) The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair. Gastroenterology 141:259–268CrossRefPubMedPubMedCentral

Kumar R, Parsad D, Kanwar AJ et al (2011) Altered levels of Ets-1 transcription factor and metalloproteinases in melanocytes from vitiligo patients. Br J Dermatol 165:285–291CrossRefPubMed

Lei TC, Virador V, Yasumoto K, Vieira WD, Toyofuku K, Hearing VJ (2002) Stimulation of melanoblast pigmentation by 8-methoxypsoralen: the involvement of microphthalmia-associated transcription factor, the protein kinase a signal pathway, and proteasome-mediated degradation. J Invest Dermatol 119(6):1341–1349CrossRefPubMed

10.

Lim YJ, Eunjoo HL, Tong HK, Sang KH, Myung SO, Seong MK, Tae-Jin Y, Chulhun K, Ji-Ho P, Sun YK (2009) Inhibitory effects of arbutin on melanin biosynthesis of α-melanocyte stimulating hormone-induced hyperpigmentation in cultured brownish guinea pig skin tissues. Arch Pharm Res 32(3):367–373CrossRefPubMed

11.

Lyros O, Rafiee P, Nie L, Medda R, Jovanovic N, Schmidt J, Mackinnon A, Venu N, Shaker R (2014) Dickkopf 1, the Wnt antagonist, is induced by acidic pH and mediates epithelial cellular senescence in human reflux esophagitis. Am J Physiol Gastrointest Liver Physiol 306:557–574CrossRef

12.

Oh SH, Kim JY, Kim MR, Do JE, Shin JY, Hann SK (2012) DKK1 is highly expressed in the dermis of vitiligo lesion: is there association between DKK1 and vitiligo? J Dermatol Sci 66:163–165CrossRefPubMed

13.

Okazaki M, Yoshimura K, Suzuki Y, Uchida G, Kitano Y et al (2003) The mechanism of epidermal hyperpigmentation in cafe-au-lait macules of neurofibromatosis type 1 (von Recklinghausen’s disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor. Br J Dermatol 148:689–697CrossRefPubMed

14.

Picardo M, Taieb A (2010) Vitiligo. Springer, HeidelbergCrossRef

15.

Purpura V, Persechino F, Belleudi F, Scrofani C, Raffa S, Persechino S et al (2014) Decreased expression of KGF/FGF7 and its receptor in pathological hypopigmentation. J Cell Mol Med 18:2553–2557CrossRefPubMedPubMedCentral

16.

Rani S, Bhardwaj S, Srivastava N, Sharma VL, Parsad D, Kumar R (2017) Senescence in the lesional fibroblasts of non-segmental vitiligo patients. Arch Dermatol Res 309:123–132CrossRefPubMed

17.

Saito H, Yasumoto K, Takeda K, Takahashi K, Yamamoto H, Shibahara S (2003) Microphthalmia-associated transcription factor in the Wnt signaling pathway. Pigment Cell Res 16:261–265CrossRefPubMed

18.

Slominski A, Wortsman J, Plonka PM, Schallreuter KU, Paus R, Tobin DJ (2005) Hair follicle pigmentation. Invest Dermatol 124:13–21CrossRef

19.

Van Amerongen R, Mikels A, Nusse R (2008) Alternative wnt signaling is initiated by distinct receptors. Sci Signal 1:re9PubMed

20.

Walsh NC, Crotti TN, Goldring SR, Gravallese EM (2005) Rheumatic diseases: the effects of inflammation on bone. Immunol Rev 208:228–251CrossRefPubMed

21.

Yamaguchi Y, Hearing VJ (2006) Melanocyte distribution and function in human skin: effects of UV radiation. In: Hearing VJ, Leong SPL. (eds) From melanocytes to malignant melanoma: the progression to malignancy. Humana Press, Totowa, pp 101–115CrossRef

22.

Yamaguchi Y, Itami S, Watabe H, Yasumoto K, Abdel-Malek ZA, Kubo T et al (2004) Mesenchymal-epithelial interactions in the skin: Increased expression of Dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J Cell Biol 165:275–285CrossRefPubMedPubMedCentral

23.

Yamaguchi Y, Morita A, Maeda A, Hearing VJ (2009) Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1). J Investig Dermatol Symp Proc 14(1):73–75CrossRefPubMedPubMedCentral

24.

Yamaguchi Y, Passeron T, Hoashi T, Watabe H, Rouzaud F, Yasumoto K (2008) Dickkopf 1 (DKK1) regulates skin pigmentation and thickness by affecting Wnt/beta-catenin signaling in keratinocytes. FASEB J 22:1009–1020CrossRefPubMed

25.

Yamaguchi Y, Passeron T, Watabe H, Yasumoto K, Rouzaud F, Hoashi T (2007) The effects of dickkopf 1 on gene expression and Wnt signaling by melanocytes: Mechanisms underlying its suppression of melanocyte function and proliferation. J Invest Dermatol 127:1217–1225CrossRefPubMed

26.

Yamaguchi Y, Takahashi K, Zmudzka BZ, Kornhauser A, Miller SA, Tadokoro T et al (2006) Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J 20:1486–1488CrossRefPubMed

Titel: Effect of Dickkopf1 on the senescence of melanocytes: in vitro study
verfasst von: Seema Rani
Rakhee Chauhan
Davinder Parsad
Ravinder Kumar
Publikationsdatum: 13.02.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Dermatological Research / Ausgabe 4/2018
Print ISSN: 0340-3696
Elektronische ISSN: 1432-069X
DOI: https://doi.org/10.1007/s00403-018-1820-1

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Effect of Dickkopf1 on the senescence of melanocytes: in vitro study

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