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07.12.2018 | Gynecologic Endocrinology and Reproductive Medicine

Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan

verfasst von: Weizhou Wang, Likun Ren, Deli Wei, Yuliang Shen, Bin Liu, Xina Wang, Fu Chen, Min Li, Ling Yan, Zhichun Feng, Wei Shang

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2019

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Abstract

Purpose

To systematically evaluate the effect of maternal and embryonic factors on in vitro fertilization and embryo transfer (IVF-ET) outcomes among Chinese patients after using hyaluronan-enriched transfer medium (HETM).

Methods

This retrospective study included 637 frozen-thawed ET cycles. Patients were divided into subgroups based on their maternal or embryonic status or treatment procedures. The implantation, clinical pregnancy, delivery, and abortion rates were compared between the HETM and control groups. In addition, the implantation and clinical pregnancy rates were used to analyze the reciprocal effect of HETM and Preimplantation genetic screening (PGS) assessment.

Results

Maternal risk factors, especially maternal aging and a low number of retrieved oocytes, have a significant adverse impact on the efficacy of HETM usage. Endometrial preparation with artificial and natural cycles but not stimulated cycles showed a satisfying outcome after IVF-ET treatment. Compared with cleavage embryos, blastocyst stage embryo transfer showed more prominent improvement when using HETM. Prolonged pre-equilibration treatment with HETM notably compromised the IVF-ET outcome. PGS-based preselection could further facilitate the HETM-induced beneficial effect on IVF-ET outcomes. The body weight, length, and sex ratio of the neonate did not significantly differ between the HETM and control groups.

Conclusion

Both the maternal and embryonic status or treatment procedures affected the IVF-ET outcomes after using HETM. HETM had a beneficial effect on advantaged IVF cycles but did not improve the outcomes of disadvantaged IVF cycles. Endometrial preparation with stimulated cycles is not recommended when using HETM. Prolonged pre-equilibration treatment must be avoided.

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Titel: Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan
verfasst von: Weizhou Wang
Likun Ren
Deli Wei
Yuliang Shen
Bin Liu
Xina Wang
Fu Chen
Min Li
Ling Yan
Zhichun Feng
Wei Shang
Publikationsdatum: 07.12.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 1/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4937-8

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Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan