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Archives of Gynecology and Obstetrics
Erschienen in:

07.12.2018 | Gynecologic Endocrinology and Reproductive Medicine

Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan

verfasst von: Weizhou Wang, Likun Ren, Deli Wei, Yuliang Shen, Bin Liu, Xina Wang, Fu Chen, Min Li, Ling Yan, Zhichun Feng, Wei Shang

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2019

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Abstract

Purpose

To systematically evaluate the effect of maternal and embryonic factors on in vitro fertilization and embryo transfer (IVF-ET) outcomes among Chinese patients after using hyaluronan-enriched transfer medium (HETM).

Methods

This retrospective study included 637 frozen-thawed ET cycles. Patients were divided into subgroups based on their maternal or embryonic status or treatment procedures. The implantation, clinical pregnancy, delivery, and abortion rates were compared between the HETM and control groups. In addition, the implantation and clinical pregnancy rates were used to analyze the reciprocal effect of HETM and Preimplantation genetic screening (PGS) assessment.

Results

Maternal risk factors, especially maternal aging and a low number of retrieved oocytes, have a significant adverse impact on the efficacy of HETM usage. Endometrial preparation with artificial and natural cycles but not stimulated cycles showed a satisfying outcome after IVF-ET treatment. Compared with cleavage embryos, blastocyst stage embryo transfer showed more prominent improvement when using HETM. Prolonged pre-equilibration treatment with HETM notably compromised the IVF-ET outcome. PGS-based preselection could further facilitate the HETM-induced beneficial effect on IVF-ET outcomes. The body weight, length, and sex ratio of the neonate did not significantly differ between the HETM and control groups.

Conclusion

Both the maternal and embryonic status or treatment procedures affected the IVF-ET outcomes after using HETM. HETM had a beneficial effect on advantaged IVF cycles but did not improve the outcomes of disadvantaged IVF cycles. Endometrial preparation with stimulated cycles is not recommended when using HETM. Prolonged pre-equilibration treatment must be avoided.
Literatur
1.
Wang HB, Dey SK (2006) Roadmap to embryo implantation: clues from mouse models. Nat Rev Genet 7:185–199CrossRefPubMed
2.
3.
Diedrich K, Fauser BC, Devroey P (2007) Griesinger G The role of the endometrium and embryo in human implantation. Hum Reprod Update 13:365–377CrossRefPubMed
4.
Norwitz ER, Schust DJ, Fisher SJ (2001) Implantation and the survival of early pregnancy. N Engl J Med 345:1400–1408CrossRefPubMed
5.
Melford SE, Taylor AH, Konje JC (2014) Of mice and (wo)men: factors influencing successful implantation including endocannabinoids. Hum Reprod Update 20:415–428CrossRefPubMed
6.
Margalioth EJ, Ben-Chetrit A, Gal M, Eldar-Geva T (2006) Investigation and treatment of repeated implantation failure following IVF-ET. Hum Reprod 21:3036–3043CrossRefPubMed
7.
8.
Edwards RG (2006) Human implantation: the last barrier in assisted reproduction technologies? Reprod Biomed Online 13:887–904CrossRefPubMed
9.
Opoien HK, Fedorcsak P, Omland AK, Abyholm T, Bjercke S, Ertzeid G, Oldereid N, Mellembakken JR, Tanbo T (2012) In vitro fertilization is a successful treatment in endometriosis-associated infertility. Fertil Steril 97:912–918CrossRefPubMed
10.
11.
Wale PL, Gardner DK (2016) The effects of chemical and physical factors on mammalian embryo culture and their importance for the practice of assisted human reproduction. Hum Reprod Update 22:2–22CrossRefPubMed
12.
Chronopoulou E, Harper JC (2015) IVF culture media: past, present and future. Hum Reprod Update 21:39–55CrossRefPubMed
13.
Fenderson BA, Stamenkovic I, Aruffo A (1993) localization of hyaluronan in mouse embryos during implantation, gastrulation and organogenesis. Differentiation 54:85–98CrossRefPubMed
14.
Carson DD, Dutt A, Tang JP (1987) Glycoconjugate synthesis during early-pregnancy—hyaluronate synthesis and function. Dev Biol 120:228–235CrossRefPubMed
15.
Campbell S, Swann HR, Aplin JD, Seif MW, Kimber SJ, Elstein M (1995) CD44 IS expressed throughout preimplantation human embryo development. Hum Reprod 10:425–430CrossRefPubMed
16.
Behzad F, Seif MW, Campbell S, Aplin JD (1994) Expression of 2 isoforms of cd44 in human endometrium. Biol Reprod 51:739–747CrossRefPubMed
17.
Gardner DK, Rodriegez-Martinez H, Lane M (1999) Fetal development after transfer is increased by replacing protein with the glycosaminoglycan hyaluronan for mouse embryo culture and transfer. Hum Reprod 14:2575–2580CrossRefPubMed
18.
Stojkovic M, Kolle S, Peinl S, Stojkovic P, Zakhartchenko V, Thompson JG, Wenigerkind H, Reichenbach HD, Sinowatz F, Wolf E (2002) Effects of high concentrations of hyaluronan in culture medium on development and survival rates of fresh and frozen-thawed bovine embryos produced in vitro. Reproduction 124:141–153CrossRefPubMed
19.
Urman B, Yakin K, Ata B, Isiklar A (2008) Balaban B Effect of hyaluronan-enriched transfer medium on implantation and pregnancy rates after day 3 and day 5 embryo transfers: a prospective randomized study. Fertil Steril 90:604–612CrossRefPubMed
20.
Valojerdi MR, Karimian L, Yazdi PE, Gilani M, Madani T, Baghestani AR (2006) Efficacy of a human embryo transfer medium: a prospective, randomized clinical trial study. J Assist Reprod Gen 23:207–212CrossRef
21.
Bontekoe S, Heineman MJ, Johnson N, Blake D (2014) Adherence compounds in embryo transfer media for assisted reproductive technologies. Cochrane Database Syst Rev
22.
Loutradi KE, Prassas I, Bili E, Sanopoulou T, Bontis I, Tarlatzis BC (2007) Evaluation of a transfer medium containing high concentration of hyaluronan in human in vitro fertilization. Fertil Steril 87:48–52CrossRefPubMed
23.
Fancsovits P, Lehner A, Murber A, Kaszas Z, Rigo J, Urbancsek J (2015) Effect of hyaluronan-enriched embryo transfer medium on IVF outcome: a prospective randomized clinical trial. Arch Gynecol Obstet 291:1173–1179CrossRefPubMed
24.
Dahdouh EM, Balayla J, Audibert F, Wilson RD, Brock J, Campagnolo C, Carroll J, Chong K, Gagnon A, Johnson J, MacDonald W, Okun N, Pastuck M, Vallee-Pouliot K (2015) Technical update: preimplantation genetic diagnosis and screening. Obstet Gynecol Surv 70:557–558CrossRef
25.
Nakagawa K, Takahashi C, Nishi Y, Jyuen H, Sugiyama R, Kuribayashi Y (2012) Sugiyama R Hyaluronan-enriched transfer medium improves outcome in patients with multiple embryo transfer failures. J Assist Reprod Gen 29:679–685CrossRef
26.
Nakagawa K, Yamano S, Moride N, Yamashita M, Yoshizawa M, Aono T (2001) Effect of activation with Ca ionophore A23187 and puromycin on the development of human oocytes that failed to fertilize after intracytoplasmic sperm injection. Fertil Steril 76:148–152CrossRefPubMed
27.
Souza A, Sampaio M, Noronha GB, Coster L, de Oliveira R, Geber S (2017) Effect of follicular flushing on reproductive outcomes in patients with poor ovarian response undergoing assisted reproductive technology. J Assist Reprod Genet 34:1353–1357CrossRefPubMedPubMedCentral
28.
Kansal KS, Ratcliffe S, Gracia CR, Martino L, Coutifaris C, Barnhart KT (2008) Randomized controlled pilot trial of luteal phase recombinant FSH stimulation in poor responders. Reprod Biomed Online 17:745–750CrossRef
29.
Yan L, Yang M, Guo H, Yang L, Wu J, Li R, Liu P, Lian Y, Zheng X, Yan J, Huang J, Li M, Wu X, Wen L, Lao K, Li R, Qiao J (2013) Tang F Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells. Nat Struct Mol Biol 20:1131CrossRefPubMed
30.
Maalouf WE, Mincheva MN, Campbell BK, Hardy IC (2014) Effects of assisted reproductive technologies on human sex ratio at birth. Fertil Steril 101:1321–1325CrossRefPubMed
31.
Dean JH, Chapman MG, Sullivan EA (2010) The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures—an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002–2006. BJOG 117:1628–1634CrossRefPubMed
32.
Chuang CC, Chen CD, Chao KH, Chen SU, Ho HN, Yang YS (2003) Age is a better predictor of pregnancy potential than basal follicle-stimulating hormone levels in women undergoing in vitro fertilization. Fertil Steril 79:63–68CrossRefPubMed
33.
La Marca A, Giulini S, Tirelli A, Bertucci E, Marsella T, Xella S, Volpe A (2007) Anti-Mullerian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology. Hum Reprod 22:766–771CrossRefPubMed
34.
Hendriks DJ, Mol B, Bancsi L, Te Velde ER, Broekmans F (2005) Antral follicle count in the prediction of poor ovarian response and pregnancy after in vitro fertilization: a meta-analysis and comparison with basal folliclestimulating hormone level. Fertil Steril 83:291–301CrossRefPubMed
35.
Scholtes M, Zeilmaker GH (1998) Blastocyst transfer in day-5 embryo transfer depends primarily on the number of oocytes retrieved and not an age. Fertil Steril 69:78–83CrossRefPubMed
36.
Charulata C, Mantravadi K, Rao DG (2017) Hyaluronan enriched embryo transfer media improves Reproductive outcomes in frozen thawed cycles for couples with repeated implantation failure. Hum Reprod 321:238–239
37.
Fu W, Yu M, Zhang XJ (2018) Effect of hyaluronic acid-enriched transfer medium on frozen-thawed embryo transfer outcomes. J Obstet Gynaecol Res 44:747–755CrossRefPubMed
38.
Chun S, Seo JE, Rim YJ, Joo JH, Lee YC, Koo YH (2016) Efficacy of hyaluronan-rich transfer medium on implantation and pregnancy rates in fresh and frozen-thawed blastocyst transfers in Korean women with previous implantation failure. Obstet Gynecol Sci 59:201–207CrossRefPubMedPubMedCentral
39.
Dietterich C, Check JH, Summers-Chase D, Yuan W, Brasile D (2007) “Embryo Glue” does not seem to improve chances of subsequent pregnancy in refractory in vitro fertilization cases. Fertil Steril 87:13–14
40.
Groenewoud ER, Cantineau AEP, Kollen BJ, Macklon NS, Cohlen BJ (2017) What is the optimal means of preparing the endometrium in frozen-thawed embryo transfer cycles? A systematic review and meta-analysis (vol 19, pg 458, 2013). Hum Reprod Update 23:255–261PubMed
41.
Page KL, Guibert J, Weitzen S, Davy C, Fauque P, Olivennes F (2005) A prospective randomized trial evaluating endometrial preparation for implantation of frozen/thawed embryos using an artificial cycle versus a stimulated cycle. Fertil Steril 841:S171–S172CrossRef
42.
Wright KP, Guibert J, Weitzen S, Davy C, Fauque P, Olivennes F (2006) Artificial versus stimulated cycles for endometrial preparation prior to frozen-thawed embryo transfer. Reprod Biomed Online 13:321–325CrossRefPubMed
43.
Kawamura T, Motoyama H, Yanaihara A, Yorimitsu T, Arichi A, Karasawa Y, Suga K, Miya K, Ishikawa S, Mizushima S, Kawamura M (2007) Clinical outcomes of two different endometrial preparation methods for cryopreserved-thawed embryo transfer in patients with a normal menstrual cycle. Reprod Med Biol 6:53–57CrossRefPubMedPubMedCentral
44.
Safari S, Razi MH, Safari S, Razi Y (2015) Routine use of EmbryoGlue((R)) as embryo transfer medium does not improve the ART outcomes. Arch Gynecol Obstet 291:433–437CrossRefPubMed
45.
Jansen K, van der Werff J, van Wachem PB, Nicolai J, de Leij L, van Luyn M (2004) A hyaluronan-based nerve guide: in vitro cytotoxicity, subcutaneous tissue reactions, and degradation in the rat. Biomaterials 25:483–489CrossRefPubMed
46.
Afify AM, Craig S, Paulino AFG (2006) Temporal variation in the distribution of hyaluronic acid, CD44s, and CD44v6 in the human endometrium across the menstrual cycle. Appl Immunohisto M M 14:328–333CrossRef
47.
Choudhary M, Zhang X, Stojkovic P, Hyslop L, Anyfantis G, Herbert M, Murdoch AP, Stojkovic M, Lako M (2007) Putative role of hyaluronan and its related genes, HAS2 and RHAMM, in human early preimplantation embryogenesis and embryonic stem cell characterization. Stem Cells 25:3045–3057CrossRefPubMed
48.
Bourguignon L, Singleton PA, Zhu HB, Zhou B (2002) Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem 277:39703–39712CrossRefPubMed
49.
Wang SJ, Bourguignon LYM (2006) Hyaluronan and the interaction between CD44 and epidermal growth factor receptor in oncogenic signaling and chemotherapy resistance in head and neck cancer. Arch Otolaryngol Head Neck Surg 132:771–778CrossRefPubMed
Metadaten
Titel
Effect of maternal and embryonic factors on frozen-thawed IVF-ET outcome after pre-equilibration with hyaluronan
verfasst von
Weizhou Wang
Likun Ren
Deli Wei
Yuliang Shen
Bin Liu
Xina Wang
Fu Chen
Min Li
Ling Yan
Zhichun Feng
Wei Shang
Publikationsdatum
07.12.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Gynecology and Obstetrics / Ausgabe 1/2019
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-018-4937-8

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