Erschienen in:
01.05.2010 | Original Article
Effect of opioid administration on cardiorespiratory and muscle oxygenation during lifting in chronic back pain patients
verfasst von:
Yagesh Bhambhani, Douglas P. Gross, Mark Haykowsky, Saifudin Rashiq
Erschienen in:
European Journal of Applied Physiology
|
Ausgabe 2/2010
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Abstract
The objectives of this study were to examine the effects of opioid administration on the acute cardiorespiratory and muscle oxygenation responses during a repetitive lifting and lowering test (RLL) to voluntary fatigue in participants with chronic low back pain (LBP). Written informed consent was obtained from 27 LBP participants (mean age 50.9 ± 16.4 years) who completed one testing session during which they were administered a saline placebo and opioid (1 μg/kg of fentanyl intravenously) in random order. The participants performed the RLL at a rate that they felt that they could sustain for an 8-h working day. Acute opioid administration increased the total lifting time and total work done during RLL by 35 and 48%, respectively (p < 0.05). However, the increased work capacity was accompanied by a significant (p < 0.05) increase in oxygen cost of 22% per unit amount of work done and significant (p < 0.05) increases in heart rate (7%) and ventilation rate (10%). Near infrared spectroscopic analysis of erector spinae oxygenation and blood volume responses during RLL indicated no significant (p > 0.05) differences between the opioid and placebo phases. These findings suggest that the increased energy cost of lifting as a result of opioid administration was due to enhanced central oxygen transport and not peripheral muscle oxygen extraction.