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08.10.2022 | Original Article

Effect of radioactivity outside the field of view on image quality of dedicated breast positron emission tomography: preliminary phantom and clinical studies

verfasst von: Yoko Satoh, Masamichi Imai, Chihiro Ikegawa, Kenji Hirata, Norifumi Abo, Mao Kusuzaki, Noriko Oyama-Manabe, Hiroshi Onishi

Erschienen in: Annals of Nuclear Medicine | Ausgabe 12/2022

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Abstract

Objective

Semi-quantitative positron emission tomography (PET) values, such as the maximum standardized uptake value (SUV_max), are widely used to identify malignant lesions and evaluate the response to treatment. The image quality of ring-shaped dedicated breast positron emission tomography (dbPET) has been known to decrease the closer it is to the detector's edge. This study aimed to investigate the effect of radioactivity (RI) outside the detector field of view (FOV) on the image quality of the ring-shaped dbPET.

Methods

A breast phantom containing the left myocardium, which was prepared using a 3D printer, filled with ¹⁸F-fluorodeoxyglucose (FDG) solution with various RI concentration ratios (RCRs) of myocardium to background and scanned with the edge of an apex positioned exactly in line with the edge of the FOV of the dbPET scanner. The phantom image quality was visually and quantitatively evaluated. Following the phantom study, left–right breast differences (the left breast uptake ratio to the right breast (LUR)) on clinical dbPET images of 74 women were quantitatively evaluated. The relationships between these parameters, clinical indices, and FDG uptake in the left myocardium on PET/computed tomography (CT) images were analyzed.

Results

The phantom study showed that the higher the RCR of the myocardium and the closer it is to the top edge of the phantom, the higher is the pixel value of the dbPET images. In a clinical study, LUR was significantly correlated with myocardial SUV_max (r = 0.96, p < 0.0001) and metabolic myocardial volume (r = 0.63, p = 0.001) for whole-body PET/CT imaging. Although no significant correlations were found between LUR and age (r = 0.05, p = 0.6865), body mass index (r = 0.03, p = 0.8178), or distance between the left myocardial apex and chest wall (r = 0.16, p = 0.1667).

Conclusions

FDG uptake in the myocardium affected dbPET images of the left breast, especially near the chest wall. Further, the effect of RI outside the FOV, such as in the myocardium, must be considered in the quantitative evaluation of breast cancer using dbPET.

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Titel: Effect of radioactivity outside the field of view on image quality of dedicated breast positron emission tomography: preliminary phantom and clinical studies
verfasst von: Yoko Satoh
Masamichi Imai
Chihiro Ikegawa
Kenji Hirata
Norifumi Abo
Mao Kusuzaki
Noriko Oyama-Manabe
Hiroshi Onishi
Publikationsdatum: 08.10.2022
Verlag: Springer Nature Singapore
Erschienen in: Annals of Nuclear Medicine / Ausgabe 12/2022
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI: https://doi.org/10.1007/s12149-022-01789-7

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

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