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Obesity Surgery
Erschienen in: Obesity Surgery 9/2020

01.06.2020 | Review

Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis

verfasst von: Javad Seyyedi, Shahab Alizadeh

Erschienen in: Obesity Surgery | Ausgabe 9/2020

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Abstract

Background

This meta-analysis was performed to assess the effects of bariatric surgery (BS) on the selected markers of endothelial dysfunction, including monocyte chemoattractant protein-1 (MCP-1), intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin.

Methods

PubMed, Scopus, and Google scholar were systematically searched to identify related studies published from inception to November 2019 to find eligible studies.

Results

A total of 29 different studies were included. BS reduced the concentrations of MCP-1 (weighted mean difference (WMD) = − 58.91; 95%CI (confidence interval), − 77.10 to − 40.72; P = ˂ 0.001), ICAM-1 (WMD = − 36.58; 95%CI, − 49.65 to − 23.52; P = ˂ 0.001), and E-selectin (WMD = − 11.22; 95%CI, − 14.43 to − 8.01; P < 0.001), but had no significant effect on VCAM-1.

Conclusion

Bariatric surgery reduces circulating concentration of MCP-1, ICAM-1, and E-selectin, but not VCAM-1.
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Metadaten
Titel
Effect of Surgically Induced Weight Loss on Biomarkers of Endothelial Dysfunction: a Systematic Review and Meta-Analysis
verfasst von
Javad Seyyedi
Shahab Alizadeh
Publikationsdatum
01.06.2020
Verlag
Springer US
Erschienen in
Obesity Surgery / Ausgabe 9/2020
Print ISSN: 0960-8923
Elektronische ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-020-04710-1

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