09.03.2017 | Original Article
Effectiveness of prothrombin complex concentrate (PCC) in neonates and infants with bleeding or risk of bleeding: a systematic review and meta-analysis
Erschienen in: European Journal of Pediatrics | Ausgabe 5/2017
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What is Known:
• Prothrombin Complex Concentrate is becoming increasingly used off-label for treatment of neonates and infants with severe bleeding or risk of severe bleeding.
• Some case reports showed PCC seemed to be effective for infants and children with coagulation factor deficiency, but evidence about the effectiveness of PCC to reverse serious Vitamin K Deficiency Bleeding is limited.
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What is New:
• As far as we know, this is the first systematic review that evaluates the effectiveness of PPC in neonates with bleeding or risk of bleeding.
• There is insufficient evidence to allow a recommendation for use of PCCs in neonates and infants.
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