Skip to main content
Erschienen in: European Journal of Applied Physiology 2/2019

29.11.2018 | Original Article

Effects of a cyborg-type robot suit HAL on cardiopulmonary burden during exercise in normal subjects

verfasst von: Yo Joon Pak, Akira Koike, Hiroki Watanabe, Tomoko Terai, Hiroshi Kubota, Masahumi Takahashi, Hirotomo Konno, Jo Kato, Isao Nishi, Akira Sato, Hiroaki Kawamoto, Kazutaka Aonuma, Masaki Ieda, Yoshiyuki Sankai

Erschienen in: European Journal of Applied Physiology | Ausgabe 2/2019

Einloggen, um Zugang zu erhalten

Abstract

Background

The hybrid assistive limb (HAL) is the world’s first cyborg-type robot suit that provides motion assistance to physically challenged patients. HAL is expected to expand the possibilities of exercise therapy for severe cardiac patients who have difficulty in moving on their own legs. As a first step, we examined whether or not the motion assistance provided by HAL during exercise could effectively reduce the cardiopulmonary burden in healthy subjects.

Methods

A total of ten healthy male adults (35 ± 12 years) underwent cardiopulmonary exercise testing (CPX) on a cycle ergometer with or without assistance from HAL. The CPX protocol consisted of four 3-min stages performed in a continuous sequence: rest, 0 W, 40 W, and 80 W. The heart rate (HR), blood pressure, oxygen uptake (VO2), minute ventilation (VE), and gas exchange ratio (R) were monitored during the CPX.

Results

At 0 W, the HR, VO2, and VE were significantly higher when HAL was used. At 80 W, however, the HR (107 ± 14 vs 114 ± 14 beats/min, p < 0.01), systolic blood pressure (141 ± 15 vs 155 ± 20 mmHg, p < 0.01), VO2 (17.6 ± 2.4 vs 19.0 ± 2.5 mL/min/kg, p < 0.05), and R (0.88 ± 0.04 vs 0.95 ± 0.09, p < 0.05) were significantly lower when HAL was used.

Conclusions

HAL has the potential to reduce cardiopulmonary burden during moderate-intensity exercise and can, therefore, be used as a support for exercise therapy. Further studies on cardiac patients are expected to contribute to the establishment of a new exercise therapy program using HAL.
Literatur
Zurück zum Zitat Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, Forman D, Franklin B, Guazzi M, Gulati M, Keteyian SJ, Lavie CJ, Macko R, Mancini D, Milani RV (2010) Clinician’s guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 122:191–225CrossRefPubMed Balady GJ, Arena R, Sietsema K, Myers J, Coke L, Fletcher GF, Forman D, Franklin B, Guazzi M, Gulati M, Keteyian SJ, Lavie CJ, Macko R, Mancini D, Milani RV (2010) Clinician’s guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 122:191–225CrossRefPubMed
Zurück zum Zitat Beaver WL, Wasserman K, Whipp BJ (1973) On-line computer analysis and breath-by-breath graphical display of exercise function tests. J Appl Physiol 34:128–132CrossRefPubMed Beaver WL, Wasserman K, Whipp BJ (1973) On-line computer analysis and breath-by-breath graphical display of exercise function tests. J Appl Physiol 34:128–132CrossRefPubMed
Zurück zum Zitat Kubota S, Nakata Y, Eguchi K, Kawamoto H, Kamibayashi K, Sakane M, Sankai Y, Ochiai N (2013) Feasibility of rehabilitation training with a newly developed wearable robot for patients with limited mobility. Arch Phys Med Rehabil 94:1080–1087CrossRefPubMed Kubota S, Nakata Y, Eguchi K, Kawamoto H, Kamibayashi K, Sakane M, Sankai Y, Ochiai N (2013) Feasibility of rehabilitation training with a newly developed wearable robot for patients with limited mobility. Arch Phys Med Rehabil 94:1080–1087CrossRefPubMed
Zurück zum Zitat Kubota S, Abe T, Kadone H, Fujii K, Shimazu Y, Marushima A, Ueno T, Kawamoto H, Hada Y, Matsumura A, Sankai Y, Yamazaki M (2017) Walking ability following hybrid assistive limb treatment for a patient with chronic myelopathy after surgery for cervical ossification of the posterior longitudinal ligament. J Spinal Cord Med 20:1–9 Kubota S, Abe T, Kadone H, Fujii K, Shimazu Y, Marushima A, Ueno T, Kawamoto H, Hada Y, Matsumura A, Sankai Y, Yamazaki M (2017) Walking ability following hybrid assistive limb treatment for a patient with chronic myelopathy after surgery for cervical ossification of the posterior longitudinal ligament. J Spinal Cord Med 20:1–9
Zurück zum Zitat Kureshi F, Kennedy KF, Jones PG, Thomas RJ, Arnold SV, Sharma P, Fendler T, Bunchanan DM, Qintar M, Ho PM, Nallamothu BK, Oldridge NB, Spertus JA (2016) Association between cardiac rehabilitation participation and health status outcomes after acute myocardial infraction. JAMA Cardiol 1:980–988CrossRefPubMedPubMedCentral Kureshi F, Kennedy KF, Jones PG, Thomas RJ, Arnold SV, Sharma P, Fendler T, Bunchanan DM, Qintar M, Ho PM, Nallamothu BK, Oldridge NB, Spertus JA (2016) Association between cardiac rehabilitation participation and health status outcomes after acute myocardial infraction. JAMA Cardiol 1:980–988CrossRefPubMedPubMedCentral
Zurück zum Zitat Neil A, Smart G, Dieberg G, Giallauria F (2013) Functional electrical stimulation for chronic heart failure: a meta-analysis. Int J Cardiol 167:80–86CrossRef Neil A, Smart G, Dieberg G, Giallauria F (2013) Functional electrical stimulation for chronic heart failure: a meta-analysis. Int J Cardiol 167:80–86CrossRef
Zurück zum Zitat Neto MG, Martinez BP, Conceição CS, Silva PE, Carvalho VO (2016) Combined exercise and inspiratory muscle training in patients with heart failure: a systematic review and meta-analysis. J Cardiopulm Rehabilit Prev 36:395–401CrossRef Neto MG, Martinez BP, Conceição CS, Silva PE, Carvalho VO (2016) Combined exercise and inspiratory muscle training in patients with heart failure: a systematic review and meta-analysis. J Cardiopulm Rehabilit Prev 36:395–401CrossRef
Zurück zum Zitat Nishitani M, Shimada K, Masaki M, Sunayama S, Kume A, Fukao K, Sai E, Onishi T, Shioya M, Sato H, Yamamoto T, Amano A, Daida H (2013) Effect of cardiac rehabilitation on muscle mass, muscle strength, and exercise tolerance in diabetic patients after coronary artery bypass grafting. J Cardiol 61:216–221CrossRefPubMed Nishitani M, Shimada K, Masaki M, Sunayama S, Kume A, Fukao K, Sai E, Onishi T, Shioya M, Sato H, Yamamoto T, Amano A, Daida H (2013) Effect of cardiac rehabilitation on muscle mass, muscle strength, and exercise tolerance in diabetic patients after coronary artery bypass grafting. J Cardiol 61:216–221CrossRefPubMed
Zurück zum Zitat Ogata T, Abe H, Samura K, Hamada O, Nonaka M, Iwaasa M, Higashi T, Fukuda H, Shiota E, Tsuboi Y, Inoue T (2015) Hybrid assistive limb (HAL) rehabilitation in patients with acute hemorrhagic stroke. Neurologia Medico Chirurgica (Tokyo) 55:901–906CrossRef Ogata T, Abe H, Samura K, Hamada O, Nonaka M, Iwaasa M, Higashi T, Fukuda H, Shiota E, Tsuboi Y, Inoue T (2015) Hybrid assistive limb (HAL) rehabilitation in patients with acute hemorrhagic stroke. Neurologia Medico Chirurgica (Tokyo) 55:901–906CrossRef
Zurück zum Zitat Sczensy-Kaiser M, Kowalewski R, Schildhauer TA, Aach M, Jansen O, Grasmücke D, Güttsches AK, Vorgerd M, Tegenthoff M (2017) Treadmill training with HAL exoskeleton—a novel approach for symptomatic therapy in patients with limb-girdle muscular dystrophy—preliminary study. Front Neurosci 11:449CrossRef Sczensy-Kaiser M, Kowalewski R, Schildhauer TA, Aach M, Jansen O, Grasmücke D, Güttsches AK, Vorgerd M, Tegenthoff M (2017) Treadmill training with HAL exoskeleton—a novel approach for symptomatic therapy in patients with limb-girdle muscular dystrophy—preliminary study. Front Neurosci 11:449CrossRef
Zurück zum Zitat Sue DY, Hansen JE, Blais M, Wasserman K (1980) Measurement and analysis of gas exchange during exercise using a programmable calculator. J Appl Physiol 49:456–461CrossRefPubMed Sue DY, Hansen JE, Blais M, Wasserman K (1980) Measurement and analysis of gas exchange during exercise using a programmable calculator. J Appl Physiol 49:456–461CrossRefPubMed
Zurück zum Zitat Takayanagi Y, Koike A, Nagayama O, Nagamine A, Qin R, Kato J, Nishi I, Himi T, Kato Y, Sato A, Yamashita T, Aonuma K (2017) Clinical significance of the overshoot phenomena of respiratory gas indices during recovery from maximal exercise testing. J Cardiol 70:598–606CrossRefPubMed Takayanagi Y, Koike A, Nagayama O, Nagamine A, Qin R, Kato J, Nishi I, Himi T, Kato Y, Sato A, Yamashita T, Aonuma K (2017) Clinical significance of the overshoot phenomena of respiratory gas indices during recovery from maximal exercise testing. J Cardiol 70:598–606CrossRefPubMed
Zurück zum Zitat Tan SJJ, Allen JC, Tan SY (2017) Determination of ideal target exercise heart rate for cardiac patients suitable for rehabilitation. Clin Cardiol 40(11):1008–1012CrossRefPubMed Tan SJJ, Allen JC, Tan SY (2017) Determination of ideal target exercise heart rate for cardiac patients suitable for rehabilitation. Clin Cardiol 40(11):1008–1012CrossRefPubMed
Metadaten
Titel
Effects of a cyborg-type robot suit HAL on cardiopulmonary burden during exercise in normal subjects
verfasst von
Yo Joon Pak
Akira Koike
Hiroki Watanabe
Tomoko Terai
Hiroshi Kubota
Masahumi Takahashi
Hirotomo Konno
Jo Kato
Isao Nishi
Akira Sato
Hiroaki Kawamoto
Kazutaka Aonuma
Masaki Ieda
Yoshiyuki Sankai
Publikationsdatum
29.11.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
European Journal of Applied Physiology / Ausgabe 2/2019
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI
https://doi.org/10.1007/s00421-018-4040-7

Weitere Artikel der Ausgabe 2/2019

European Journal of Applied Physiology 2/2019 Zur Ausgabe