Skip to main content
Erschienen in: Journal of Pediatric Neuropsychology 1-2/2016

01.06.2016 | Review Article

Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors

verfasst von: Jesse C. Bledsoe

Erschienen in: Journal of Pediatric Neuropsychology | Ausgabe 1-2/2016

Einloggen, um Zugang zu erhalten

Abstract

There is emerging research connecting neuroimaging correlates and neurocognitive functioning in pediatric brain tumors. Current work has attempted to measure the impact of cranial radiation on brain and behavior outcomes with the goal of better understanding the mechanisms of treatment late effects. While critical for treatment, cranial radiation can have a substantial impact on the developing brain and on neuropsychological development. This paper provides a critical review of the most recent empirical structural and functional neuroimaging research evaluating the impact of cranial radiation on neuropsychological functioning in pediatric brain tumors. The importance in study methodology, potential outcome moderating variables, limitations, and future directions is discussed.
Literatur
Zurück zum Zitat Achenbach, T. M. (1991). Manual for the Child Behavior Checklist and Revised Child Behavior Profile. Burlington, VT: T.M. Achenbach. Achenbach, T. M. (1991). Manual for the Child Behavior Checklist and Revised Child Behavior Profile. Burlington, VT: T.M. Achenbach.
Zurück zum Zitat Antsey, K. J., Windsor, T. D., Jorm, A. F., Christensen, H., & Rodgers, B. (2004). Association of Pulmonary Function with Cognitive Performance in Early, Middle and Late Adulthood. Gerontology, 50(4), 230–234.CrossRef Antsey, K. J., Windsor, T. D., Jorm, A. F., Christensen, H., & Rodgers, B. (2004). Association of Pulmonary Function with Cognitive Performance in Early, Middle and Late Adulthood. Gerontology, 50(4), 230–234.CrossRef
Zurück zum Zitat Aukema, E. J., Caan, M. W. A., Oudhuis, N., Majoie, C. B., Vos, F. M., Reneman, L., et al. (2009). White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors. International Journal of Radiation Oncology and Biol Phys., 74(3), 837–843.CrossRef Aukema, E. J., Caan, M. W. A., Oudhuis, N., Majoie, C. B., Vos, F. M., Reneman, L., et al. (2009). White matter fractional anisotropy correlates with speed of processing and motor speed in young childhood cancer survivors. International Journal of Radiation Oncology and Biol Phys., 74(3), 837–843.CrossRef
Zurück zum Zitat Barnea-Goraly, N., Menon, V., Eckert, M., Tamm, L., Bammer, R., Karchemskiy, A., et al. (2005). White matter development during childhood and adolescence: a cross-sectional diffusion tensor imaging study. Cerebral Cortex, 15(12), 1848–1854.CrossRefPubMed Barnea-Goraly, N., Menon, V., Eckert, M., Tamm, L., Bammer, R., Karchemskiy, A., et al. (2005). White matter development during childhood and adolescence: a cross-sectional diffusion tensor imaging study. Cerebral Cortex, 15(12), 1848–1854.CrossRefPubMed
Zurück zum Zitat Brinkman, T. M., Reddick, W. E., Luxton, J., Glass, J. O., Sabin, N. D., Srivastava, D. K., et al. (2012). Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. Neuro-Oncology, 14, iv25-iv36. Brinkman, T. M., Reddick, W. E., Luxton, J., Glass, J. O., Sabin, N. D., Srivastava, D. K., et al. (2012). Cerebral white matter integrity and executive function in adult survivors of childhood medulloblastoma. Neuro-Oncology, 14, iv25-iv36.
Zurück zum Zitat Brookshire, B. L., Fletcher, J. M., Bohan, T. P., Landry, S. H., Davidson, K. C., Francis, D. J. (1995). Verbal and nonverbal skill descrepancies in children with hydrocephalus: a five-year longitudinal study. Journal of Pediatric Psychology, 20(6), 785–800. Brookshire, B. L., Fletcher, J. M., Bohan, T. P., Landry, S. H., Davidson, K. C., Francis, D. J. (1995). Verbal and nonverbal skill descrepancies in children with hydrocephalus: a five-year longitudinal study. Journal of Pediatric Psychology, 20(6), 785–800.
Zurück zum Zitat Catsman-Berrevoets, C. E., & Aarsen, F. K. (2010). The spectrum of neurobehavioral deficits in the Posterior Fossa Syndrome in children after cerebellar tumor surgery. Cortex, 46(7), 933–946.CrossRefPubMed Catsman-Berrevoets, C. E., & Aarsen, F. K. (2010). The spectrum of neurobehavioral deficits in the Posterior Fossa Syndrome in children after cerebellar tumor surgery. Cortex, 46(7), 933–946.CrossRefPubMed
Zurück zum Zitat Ceci, S. J. (1991). How much does schooling influence general intelligence and its cognitive components? A reassessment of the evidence. Developmental Psychology, 27(5), 703–722.CrossRef Ceci, S. J. (1991). How much does schooling influence general intelligence and its cognitive components? A reassessment of the evidence. Developmental Psychology, 27(5), 703–722.CrossRef
Zurück zum Zitat Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan executive functioning system: examiner’s manual. San Antonio, TX: The Psychological Corporation. Delis, D. C., Kaplan, E., & Kramer, J. H. (2001). Delis-Kaplan executive functioning system: examiner’s manual. San Antonio, TX: The Psychological Corporation.
Zurück zum Zitat Giedd, J., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., et al. (1999). Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience, 2(10), 861–863.CrossRefPubMed Giedd, J., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., et al. (1999). Brain development during childhood and adolescence: a longitudinal MRI study. Nature Neuroscience, 2(10), 861–863.CrossRefPubMed
Zurück zum Zitat Giedd, J., Rumsey, J., Castellanos, F. X., Rajapakse, J. C., Kaysen, D., Vaituzis, A. C., et al. (1996a). A quantitative MRI study of the corpus callosum in children and adolescents. Brain Research. Developmental Brain Research, 26(91), 274–280.CrossRef Giedd, J., Rumsey, J., Castellanos, F. X., Rajapakse, J. C., Kaysen, D., Vaituzis, A. C., et al. (1996a). A quantitative MRI study of the corpus callosum in children and adolescents. Brain Research. Developmental Brain Research, 26(91), 274–280.CrossRef
Zurück zum Zitat Giedd, J., Snell, J. W., Lange, N., Rajapakse, J. C., Casey, B. J., Kozuch, P. L., et al. (1996b). Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cerebral Cortex, 6, 551–559.CrossRefPubMed Giedd, J., Snell, J. W., Lange, N., Rajapakse, J. C., Casey, B. J., Kozuch, P. L., et al. (1996b). Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cerebral Cortex, 6, 551–559.CrossRefPubMed
Zurück zum Zitat Gottardo, N. G., & Gajjar, A. (2006). Current therapy for medulloblastoma. Current Treatment Options Neurologyl, 8, 4. Gottardo, N. G., & Gajjar, A. (2006). Current therapy for medulloblastoma. Current Treatment Options Neurologyl, 8, 4.
Zurück zum Zitat Hoppe-Hirsch, E., Laroussinie, F., Brunet, L., Sainte-Rose, C., Renier, D., Cinalli, G., et al. (1998). Late outcome of the surgical treatment of hydrocephalus. Child's Nervous System, 14, 97–99.CrossRefPubMed Hoppe-Hirsch, E., Laroussinie, F., Brunet, L., Sainte-Rose, C., Renier, D., Cinalli, G., et al. (1998). Late outcome of the surgical treatment of hydrocephalus. Child's Nervous System, 14, 97–99.CrossRefPubMed
Zurück zum Zitat Howlader, N., Noone, A. M., Krapcho, M., Garshell, J., Neyman, N., Altekruse, S. F., et al. (2013). SEER Cancer Statistics Review, 1975–2010. Bethesda, MD: National Cancer Institute. Howlader, N., Noone, A. M., Krapcho, M., Garshell, J., Neyman, N., Altekruse, S. F., et al. (2013). SEER Cancer Statistics Review, 1975–2010. Bethesda, MD: National Cancer Institute.
Zurück zum Zitat Huttenlocher, P. R. (1979). Synaptic density in human frontal cortex - Developmental changes and effects of aging. Brain Research, 163(2), 195–205.CrossRefPubMed Huttenlocher, P. R. (1979). Synaptic density in human frontal cortex - Developmental changes and effects of aging. Brain Research, 163(2), 195–205.CrossRefPubMed
Zurück zum Zitat Huttenlocher, P. R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28(6), 517–527.CrossRefPubMed Huttenlocher, P. R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28(6), 517–527.CrossRefPubMed
Zurück zum Zitat Huttenlocher, P. R. (1999). Dendritic and synaptic development in human cerebral cortex: time course and critical periods. Developmental Neuropsychology, 16(3), 347–349.CrossRef Huttenlocher, P. R. (1999). Dendritic and synaptic development in human cerebral cortex: time course and critical periods. Developmental Neuropsychology, 16(3), 347–349.CrossRef
Zurück zum Zitat Khong, P. L., Kwong, D., Chan, G. C. F., Sham, J., Chan, F., & Ooi, G. (2003). Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: a pilot study. American Journal of Neuroradiology, 24, 734–740.PubMed Khong, P. L., Kwong, D., Chan, G. C. F., Sham, J., Chan, F., & Ooi, G. (2003). Diffusion-tensor imaging for the detection and quantification of treatment-induced white matter injury in children with medulloblastoma: a pilot study. American Journal of Neuroradiology, 24, 734–740.PubMed
Zurück zum Zitat Khong, P. L., Leung, L. H. T., Chan, G. C. F., Kwong, D., Wong, W., Cao, G., et al. (2005). White matter anisotropy in childhood medulloblastoma survivors: association with neurotoxicity risk factors. Radiology, 23, 647–652.CrossRef Khong, P. L., Leung, L. H. T., Chan, G. C. F., Kwong, D., Wong, W., Cao, G., et al. (2005). White matter anisotropy in childhood medulloblastoma survivors: association with neurotoxicity risk factors. Radiology, 23, 647–652.CrossRef
Zurück zum Zitat Kieffer-Renaux, V., Bulteau, C., Grill, J., Kalifa, C., Viguire, D., & Jambaque, I. (2000). Patterns of neuropsychological deficits in children with medulloblastoma according to craniospinal irradiation doses. Developmental Medicine and Child Neurology, 42(11), 741–745.CrossRefPubMed Kieffer-Renaux, V., Bulteau, C., Grill, J., Kalifa, C., Viguire, D., & Jambaque, I. (2000). Patterns of neuropsychological deficits in children with medulloblastoma according to craniospinal irradiation doses. Developmental Medicine and Child Neurology, 42(11), 741–745.CrossRefPubMed
Zurück zum Zitat Law, N., Bouffet, E., Laughlin, S., Laperriere, N., Briere, M., Strother, D., et al. (2011). Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: impact on working memory. NeuroImage, 56, 223–2248.CrossRef Law, N., Bouffet, E., Laughlin, S., Laperriere, N., Briere, M., Strother, D., et al. (2011). Cerebello-thalamo-cerebral connections in pediatric brain tumor patients: impact on working memory. NeuroImage, 56, 223–2248.CrossRef
Zurück zum Zitat Leung, L. H. T., Ooi, G., Kwong, D., Chan, G. C. F., Cao, G., & Khong, P. L. (2004). White-matter diffusion anisotropy after chemo-irradiation: a statistical parametric mapping study and histogram analysis. NeuroImage, 21, 261–268.CrossRefPubMed Leung, L. H. T., Ooi, G., Kwong, D., Chan, G. C. F., Cao, G., & Khong, P. L. (2004). White-matter diffusion anisotropy after chemo-irradiation: a statistical parametric mapping study and histogram analysis. NeuroImage, 21, 261–268.CrossRefPubMed
Zurück zum Zitat Liu, A. K., Marcus, K. J., Fischl, B., Grant, P. E., Poussaint, T. Y., Rivkin, M., et al. (2007). Changes in cerebral cortex of children treated for medulloblastoma. International Journal of Radiation Oncology and Biol Phys., 68(4), 992–998.CrossRef Liu, A. K., Marcus, K. J., Fischl, B., Grant, P. E., Poussaint, T. Y., Rivkin, M., et al. (2007). Changes in cerebral cortex of children treated for medulloblastoma. International Journal of Radiation Oncology and Biol Phys., 68(4), 992–998.CrossRef
Zurück zum Zitat Mabbott, D. J., Spiegler, B. J., Greenberg, M. L., Rutka, J. T., Hyder, D. J., & Bouffet, E. (2005). Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. Journal of Clinical Oncology, 23(10), 2256–2263.CrossRefPubMed Mabbott, D. J., Spiegler, B. J., Greenberg, M. L., Rutka, J. T., Hyder, D. J., & Bouffet, E. (2005). Serial evaluation of academic and behavioral outcome after treatment with cranial radiation in childhood. Journal of Clinical Oncology, 23(10), 2256–2263.CrossRefPubMed
Zurück zum Zitat Merchant, T. E., Kiehna, E. N., Li, C., Shukla, H., Sengupta, S., Xiong, X., et al. (2006). Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma. International Journal of Radiation Oncology and Biol Phys., 65(1), 210–221.CrossRef Merchant, T. E., Kiehna, E. N., Li, C., Shukla, H., Sengupta, S., Xiong, X., et al. (2006). Modeling radiation dosimetry to predict cognitive outcomes in pediatric patients with CNS embryonal tumors including medulloblastoma. International Journal of Radiation Oncology and Biol Phys., 65(1), 210–221.CrossRef
Zurück zum Zitat Merchant, T. E., Lee, H., Zhu, J., Xiong, X., Wheeler, G., Phipps, S., Sanford, R.A. (2004). The effect of hydrocephalus on intelligence quotient in children with localized infratentorial ependymoma before and after focal radiation therapy. Journal of Neurosurgery, 2(101), 159–168. Merchant, T. E., Lee, H., Zhu, J., Xiong, X., Wheeler, G., Phipps, S., Sanford, R.A. (2004). The effect of hydrocephalus on intelligence quotient in children with localized infratentorial ependymoma before and after focal radiation therapy. Journal of Neurosurgery, 2(101), 159–168.
Zurück zum Zitat Merchant, T. E., Mulhern, R. K., Krasin, M. J., Kun, L., Williams, T., Li, C., et al. (2004). Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. Journal of Clinical Oncology, 1(22), 3156–3162.CrossRef Merchant, T. E., Mulhern, R. K., Krasin, M. J., Kun, L., Williams, T., Li, C., et al. (2004). Preliminary results from a phase II trial of conformal radiation therapy and evaluation of radiation-related CNS effects for pediatric patients with localized ependymoma. Journal of Clinical Oncology, 1(22), 3156–3162.CrossRef
Zurück zum Zitat Morris, E. B., Phillips, N. S., Laningham, F. H., Patay, Z., Gajjar, A., Wallace, D., et al. (2009). Proximal dentatothalamocortical tract involvement in posterior fossa syndrome. Brain, 132(11), 3087–3095.CrossRefPubMedPubMedCentral Morris, E. B., Phillips, N. S., Laningham, F. H., Patay, Z., Gajjar, A., Wallace, D., et al. (2009). Proximal dentatothalamocortical tract involvement in posterior fossa syndrome. Brain, 132(11), 3087–3095.CrossRefPubMedPubMedCentral
Zurück zum Zitat Mulhern, R. K., Palmer, S. L., Merchant, T. E., Wallace, D., Kocak, M., Brouwers, P., et al. (2005). Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. Journal of Clinical Oncology, 23(24), 5511–5519.CrossRefPubMed Mulhern, R. K., Palmer, S. L., Merchant, T. E., Wallace, D., Kocak, M., Brouwers, P., et al. (2005). Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. Journal of Clinical Oncology, 23(24), 5511–5519.CrossRefPubMed
Zurück zum Zitat Mulhern, R. K., Palmer, S. L., Reddick, W. E., Glass, J. O., Kun, L. E., Taylor, J., et al. (2001). Risk of Young Age for Selected Neurocognitive Deficits in Medulloblastoma Are Associated With White Matter Loss. Journal of Clinical Oncology, 19(2), 472–479.PubMed Mulhern, R. K., Palmer, S. L., Reddick, W. E., Glass, J. O., Kun, L. E., Taylor, J., et al. (2001). Risk of Young Age for Selected Neurocognitive Deficits in Medulloblastoma Are Associated With White Matter Loss. Journal of Clinical Oncology, 19(2), 472–479.PubMed
Zurück zum Zitat Mulhern, R. K., Reddick, W. E., Palmer, S. L., Glass, J. O., Elkin, T. D., Kun, L. E., et al. (1999). Neurocognitive Deficits in Medulloblastoma Survivors and White Matter Loss. Annals of Neurology, 46(6), 834–841.CrossRefPubMed Mulhern, R. K., Reddick, W. E., Palmer, S. L., Glass, J. O., Elkin, T. D., Kun, L. E., et al. (1999). Neurocognitive Deficits in Medulloblastoma Survivors and White Matter Loss. Annals of Neurology, 46(6), 834–841.CrossRefPubMed
Zurück zum Zitat Nagel, B. J., Palmer, S. L., Reddick, W. E., Glass, J. O., Helton, K., Wu, S., et al. (2004). Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation. American Journal of Neuroradiology, 25, 1575–1582.PubMed Nagel, B. J., Palmer, S. L., Reddick, W. E., Glass, J. O., Helton, K., Wu, S., et al. (2004). Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation. American Journal of Neuroradiology, 25, 1575–1582.PubMed
Zurück zum Zitat Noble, K. G., Houston, S. M., Kan, E., & Sowell, E. R. (2012). Neural correlates of socioeconomic status in the developing human brain. Developmental Science, 15(4), 516–527.CrossRefPubMed Noble, K. G., Houston, S. M., Kan, E., & Sowell, E. R. (2012). Neural correlates of socioeconomic status in the developing human brain. Developmental Science, 15(4), 516–527.CrossRefPubMed
Zurück zum Zitat Orru, G., Pettersson-Yeo, W., Marquand, A. F., Sartori, G., & Mechelli, A. (2012). Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review. Neuroscience and Biobehavioral Reviews, 36, 1140–1152.CrossRefPubMed Orru, G., Pettersson-Yeo, W., Marquand, A. F., Sartori, G., & Mechelli, A. (2012). Using support vector machine to identify imaging biomarkers of neurological and psychiatric disease: a critical review. Neuroscience and Biobehavioral Reviews, 36, 1140–1152.CrossRefPubMed
Zurück zum Zitat Ostrom, Q. T., Gittleman, H., Liao, P., Rouse, C., Chen, Y., Dowling, J., Ostrom, Q. T., Gittleman, H., Liao, P., Rouse, C., Chen, Y., Dowling, J., et al. (2014). CBTRUS Statistical Report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncology, 16(s5), iv1–iv63.CrossRefPubMedPubMedCentral Ostrom, Q. T., Gittleman, H., Liao, P., Rouse, C., Chen, Y., Dowling, J., Ostrom, Q. T., Gittleman, H., Liao, P., Rouse, C., Chen, Y., Dowling, J., et al. (2014). CBTRUS Statistical Report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncology, 16(s5), iv1–iv63.CrossRefPubMedPubMedCentral
Zurück zum Zitat Palmer, S. L., Goloubeva, O., Reddick, W. E., Glass, J. O., Gajjar, A., Kun, L., et al. (2001). Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. Journal of Clinical Oncology, 19(8), 2302–2308.PubMed Palmer, S. L., Goloubeva, O., Reddick, W. E., Glass, J. O., Gajjar, A., Kun, L., et al. (2001). Patterns of intellectual development among survivors of pediatric medulloblastoma: a longitudinal analysis. Journal of Clinical Oncology, 19(8), 2302–2308.PubMed
Zurück zum Zitat Palmer, S. L., Hassall, T., Evankovich, K., Mabbott, D. J., Bonner, M., Deluca, C., et al. (2010). Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro-Oncology, 12(12), 1311–1317.PubMedPubMedCentral Palmer, S. L., Hassall, T., Evankovich, K., Mabbott, D. J., Bonner, M., Deluca, C., et al. (2010). Neurocognitive outcome 12 months following cerebellar mutism syndrome in pediatric patients with medulloblastoma. Neuro-Oncology, 12(12), 1311–1317.PubMedPubMedCentral
Zurück zum Zitat Palmer, S. L., Reddick, W. E., Glass, J. O., Gajjar, A., Goloubeva, O., & Mulhern, R. K. (2002). Decline in corpus callosum volume among pediatric patients with medulloblastoma: longitudinal MR imaging study. American Journal of Neuroradiology, 23, 1088–1094.PubMed Palmer, S. L., Reddick, W. E., Glass, J. O., Gajjar, A., Goloubeva, O., & Mulhern, R. K. (2002). Decline in corpus callosum volume among pediatric patients with medulloblastoma: longitudinal MR imaging study. American Journal of Neuroradiology, 23, 1088–1094.PubMed
Zurück zum Zitat Reddick, W. E., Glass, J. O., Palmer, S. L., Wu, S., Gajjar, A., Langston, J. W., et al. (2005). Atypical white matter volume development in children following craniospinal irradiation. Neuro-Oncology, 7(1), 12–19.CrossRefPubMedPubMedCentral Reddick, W. E., Glass, J. O., Palmer, S. L., Wu, S., Gajjar, A., Langston, J. W., et al. (2005). Atypical white matter volume development in children following craniospinal irradiation. Neuro-Oncology, 7(1), 12–19.CrossRefPubMedPubMedCentral
Zurück zum Zitat Reddick, W. E., Mulhern, R. K., Elkin, T. D., Glass, J. O., Merchant, T. E., & Langston, J. W. (1998). A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors. Magnetic Resonance Imaging, 16(4), 413–421.CrossRefPubMed Reddick, W. E., Mulhern, R. K., Elkin, T. D., Glass, J. O., Merchant, T. E., & Langston, J. W. (1998). A hybrid neural network analysis of subtle brain volume differences in children surviving brain tumors. Magnetic Resonance Imaging, 16(4), 413–421.CrossRefPubMed
Zurück zum Zitat Reddick, W. E., Russell, J. M., Glass, J. O., Xiong, X., Mulhern, R. K., Langston, J. W., et al. (2000). Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation. Magnetic Resonance Imaging, 18, 787–793.CrossRefPubMed Reddick, W. E., Russell, J. M., Glass, J. O., Xiong, X., Mulhern, R. K., Langston, J. W., et al. (2000). Subtle white matter volume differences in children treated for medulloblastoma with conventional or reduced dose craniospinal irradiation. Magnetic Resonance Imaging, 18, 787–793.CrossRefPubMed
Zurück zum Zitat Reddick, W. E., White, H. A., Glass, J. O., Wheeler, G. C., Thompson, S. J., Gajjar, A., et al. (2003). Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer, 97(10), 2512–2519.CrossRefPubMed Reddick, W. E., White, H. A., Glass, J. O., Wheeler, G. C., Thompson, S. J., Gajjar, A., et al. (2003). Developmental model relating white matter volume to neurocognitive deficits in pediatric brain tumor survivors. Cancer, 97(10), 2512–2519.CrossRefPubMed
Zurück zum Zitat Robinson, K. E., Pearson, M. M., Cannistraci, C., Anderson, A. W., & Kuttesch, J. (2014). Neuroimaging of executive function in survivors of pediatric brain tumors in healthy controls. Neuropsychology, 28(5), 791–800.CrossRefPubMed Robinson, K. E., Pearson, M. M., Cannistraci, C., Anderson, A. W., & Kuttesch, J. (2014). Neuroimaging of executive function in survivors of pediatric brain tumors in healthy controls. Neuropsychology, 28(5), 791–800.CrossRefPubMed
Zurück zum Zitat Turkheimer, E., Haley, A., Waldron, M., D'Onofrio, B., & Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14(6), 623–628.CrossRefPubMed Turkheimer, E., Haley, A., Waldron, M., D'Onofrio, B., & Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14(6), 623–628.CrossRefPubMed
Zurück zum Zitat Wechsler, D. (2003). Wechsler Intelligence Scale for Children (WISC-IV) (4th ed.). San Antonio, TX: The Psychological Corporation. Wechsler, D. (2003). Wechsler Intelligence Scale for Children (WISC-IV) (4th ed.). San Antonio, TX: The Psychological Corporation.
Zurück zum Zitat Wolfe, K. R., Madan-Swain, A., Hunter, G. R., Reddy, A. T., Banos, J., & Kana, R. K. (2013). An fMRI investigation of working memory and its relationship with cardiorespiratory fitness in pediatric posterior fossa tumor survivors who received cranial radiation therapy. Pediatric Blood and Cancer, 60(4), 669–675.CrossRefPubMedPubMedCentral Wolfe, K. R., Madan-Swain, A., Hunter, G. R., Reddy, A. T., Banos, J., & Kana, R. K. (2013). An fMRI investigation of working memory and its relationship with cardiorespiratory fitness in pediatric posterior fossa tumor survivors who received cranial radiation therapy. Pediatric Blood and Cancer, 60(4), 669–675.CrossRefPubMedPubMedCentral
Zurück zum Zitat Yule, S. M., Hide, T. A. H., Cranney, M., Simpson, E., Barrett, A. (2001). Low grade astrocytomas in the West of Scotland 1987–96: treatment, outcome, and cognitive functioning. Archives of Disease in Childhood, 84, 61–64. Yule, S. M., Hide, T. A. H., Cranney, M., Simpson, E., Barrett, A. (2001). Low grade astrocytomas in the West of Scotland 1987–96: treatment, outcome, and cognitive functioning. Archives of Disease in Childhood, 84, 61–64.
Metadaten
Titel
Effects of Cranial Radiation on Structural and Functional Brain Development in Pediatric Brain Tumors
verfasst von
Jesse C. Bledsoe
Publikationsdatum
01.06.2016
Verlag
Springer International Publishing
Erschienen in
Journal of Pediatric Neuropsychology / Ausgabe 1-2/2016
Print ISSN: 2199-2681
Elektronische ISSN: 2199-2673
DOI
https://doi.org/10.1007/s40817-015-0008-2

Weitere Artikel der Ausgabe 1-2/2016

Journal of Pediatric Neuropsychology 1-2/2016 Zur Ausgabe

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Schwindelursache: Massagepistole lässt Otholiten tanzen

14.05.2024 Benigner Lagerungsschwindel Nachrichten

Wenn jüngere Menschen über ständig rezidivierenden Lagerungsschwindel klagen, könnte eine Massagepistole der Auslöser sein. In JAMA Otolaryngology warnt ein Team vor der Anwendung hochpotenter Geräte im Bereich des Nackens.

Schützt Olivenöl vor dem Tod durch Demenz?

10.05.2024 Morbus Alzheimer Nachrichten

Konsumieren Menschen täglich 7 Gramm Olivenöl, ist ihr Risiko, an einer Demenz zu sterben, um mehr als ein Viertel reduziert – und dies weitgehend unabhängig von ihrer sonstigen Ernährung. Dafür sprechen Auswertungen zweier großer US-Studien.

Bluttest erkennt Parkinson schon zehn Jahre vor der Diagnose

10.05.2024 Parkinson-Krankheit Nachrichten

Ein Bluttest kann abnorm aggregiertes Alpha-Synuclein bei einigen Menschen schon zehn Jahre vor Beginn der motorischen Parkinsonsymptome nachweisen. Mit einem solchen Test lassen sich möglicherweise Prodromalstadien erfassen und die Betroffenen früher behandeln.

Darf man die Behandlung eines Neonazis ablehnen?

08.05.2024 Gesellschaft Nachrichten

In einer Leseranfrage in der Zeitschrift Journal of the American Academy of Dermatology möchte ein anonymer Dermatologe bzw. eine anonyme Dermatologin wissen, ob er oder sie einen Patienten behandeln muss, der eine rassistische Tätowierung trägt.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.