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26.10.2018 | Psychiatry and Preclinical Psychiatric Studies - Original Article

Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction

verfasst von: Anderson R. Stolf, Renata B. Cupertino, Diana Müller, Breno Sanvicente-Vieira, Tatiana Roman, Eduardo S. Vitola, Eugenio H. Grevet, Lisia von Diemen, Felix H. P. Kessler, Rodrigo Grassi-Oliveira, Claiton H. D. Bau, Diego L. Rovaris, Flavio Pechansky, Jaqueline B. Schuch

Erschienen in: Journal of Neural Transmission | Ausgabe 2/2019

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Abstract

There is evidence that dopamine receptors D2 (DRD2) and D4 (DRD4) polymorphisms may influence substance use disorders (SUD) susceptibility both individually and through their influence in the formation of DRD2–DRD4 heteromers. The dopaminergic role on the vulnerability to addiction appears to be influenced by sex. A cross-sectional study with 307 crack cocaine addicts and 770 controls was conducted. The influence of DRD2 rs2283265 and DRD4 48 bp VNTR in exon 3 variants, as well as their interaction on crack cocaine addiction susceptibility and severity were evaluated in women and men separately. An association between the DRD2 T allele and crack cocaine addiction was found in women. In this same group, interaction analysis demonstrated that the presence of DRD2-T allele and concomitant absence of DRD4-7R allele were associated with risk for crack cocaine addiction. No influence of DRD2 and DRD4 variants was observed in men regarding addiction severity. This study reinforces the role of dopaminergic genes in externalizing behaviors, especially the influence of DRD2–DRD4 interaction on SUD. This is the fourth sample that independently associated the DRD2–DRD4 interaction with SUD itself or related disorders. In addition, our findings point out to a potential difference of dopaminergic neurotransmission across sex influencing addiction susceptibility.

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Titel: Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction
verfasst von: Anderson R. Stolf
Renata B. Cupertino
Diana Müller
Breno Sanvicente-Vieira
Tatiana Roman
Eduardo S. Vitola
Eugenio H. Grevet
Lisia von Diemen
Felix H. P. Kessler
Rodrigo Grassi-Oliveira
Claiton H. D. Bau
Diego L. Rovaris
Flavio Pechansky
Jaqueline B. Schuch
Publikationsdatum: 26.10.2018
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 2/2019
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-018-1946-5

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