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Journal of NeuroVirology

Erschienen in:

28.08.2017

Effects of sex and HIV serostatus on spatial navigational learning and memory among cocaine users

verfasst von: J. Fogel, L. H. Rubin, P. Maki, M. K. Keutmann, R. Gonzalez, J. Vassileva, E. M. Martin

Erschienen in: Journal of NeuroVirology | Ausgabe 6/2017

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Abstract

Spatial learning and memory are critically dependent on the integrity of hippocampal systems. Functional MRI and neuropathological studies show that hippocampal circuitry is prominently affected among HIV-seropositive individuals, but potential spatial learning and memory deficits have not been studied in detail in this population. We investigated the independent and interactive effects of sex and HIV serostatus on performance of a spatial learning and memory task in a sample of 181 individuals with a history of cocaine dependence. We found that men showed faster times to completion on immediate recall trials compared with women and that delayed recall was significantly poorer among HIV-infected compared with HIV-uninfected participants. Additionally, a sex × serostatus effect was found on the total number of completed learning trials. Specifically, HIV-infected men successfully completed more learning trials compared with HIV-infected women. Results are discussed in the context of recent reports of sex and HIV serostatus effects on episodic memory performance.

Data from 15 individuals on opioid substitution therapy were inadvertently included in the analyses. Follow-up sensitivity analyses were conducted removing those individuals on opioid substitution therapy to ensure that the present findings were not due to those select subjects, and since the findings did not change, those individuals were included in the final sample.

Participants who tested positive for cannabis were not excluded if testing was negative for all other substances. The presence of THC metabolites in the urine did not necessarily indicate cannabis use within 1–2 days prior to testing due to its much longer half-life.

Ten participants (5% of total sample) were unable or refused to complete the MI task due to difficulty in handling the joystick or understanding task instructions and were not included in the final total of 181 participants.

Becker JB, Hu M (2008) Sex differences in drug abuse. Front Neuroendocrinol 29:36–47CrossRefPubMed

Benedict RH (1997). Brief visuospatial memory test—revised: professional manual

Benedict RH, Schretlen D, Groninger L, Dobraski M, Shpritz B (1996) Revision of the Brief Visuospatial Memory Test: studies of normal performance, reliability, and validity. Psychol Assess 8:145–153CrossRef

Benedict RH, Schretlen D, Groninger L, Brandt J (1998) Hopkins Verbal Learning Test—Revised: normative data and analysis of inter-form and test-retest reliability. Clin Neuropsychol 12:43–55CrossRef

Blake DD, Weathers FW, Nagy LM, Kaloupek DG, Gusman FD, Charney DS, Keane TM (1995) The development of a clinician-administered PTSD scale. J Trauma Stress 8:75–90CrossRefPubMed

Carey AN, Sypek EI, Singh HD, Kaufman MJ, McLaughlin JP (2012) Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse. Behav Brain Res 229:48–56CrossRefPubMed

Castelo JM, Sherman SJ, Courtney MG, Melrose RJ, Stern CE (2006) Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding. Neurology 66:1688–1695CrossRefPubMed

Cook JA, Burke-Miller JK, Cohen MH, Cook RL, Vlahov D, Wilson TE, Golub ET, Schwartz RM, Howard AA, Ponath C, Plankey MW, Grey DD (2008) Crack cocaine, disease progression, and mortality in a multi-center cohort of HIV-1 positive women. AIDS (London, England) 22:1355CrossRef

Driscoll I, Hamilton DA, Yeo RA, Brooks WM, Sutherland RJ (2005) Virtual navigation in humans: the impact of age, sex, and hormones on place learning. Horm Behav 47:326–335CrossRefPubMed

Fama R, Rosenbloom MJ, Sassoon SA, Pfefferbaum A, Sullivan EV (2012) Differential effect of alcoholism and HIV infection on visuomotor procedural learning and retention. Alcohol Clin Exp Res 36:1738–1747CrossRefPubMedPubMedCentral

First MB, Spitzer RL, Gibbon M, Williams JB (1995) Structured clinical interview for DSM-IV axis I disorders. New York State Psychiatric Institute, New York

Greenfield SF, Back SE, Lawson K, Brady KT (2010) Substance abuse in women. Psychiatr Clin North Am 33:339–355CrossRefPubMedPubMedCentral

Heaton RK, Marcotte TD, Mindt MR, Sadek J, Moore DJ, Bentley H, McCutchan JA, Reicks C, Grant I (2004) The impact of HIV-associated neuropsychological impairment on everyday functioning. J Int Neuropsychol Soc 10:317–331CrossRefPubMed

Heaton RK, Franklin DR, Ellis RJ, McCutchan JA, Letendre SL, LeBlanc S, Corkran SH, Duarte NA, Clifford DB, Woods SP, Collier AC (2011) HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J NeuroVirol 17:3–16

Hinkin CH, Hardy DJ, Mason KI, Castellon SA, Lam MN, Stefaniak M, Zolnikov B (2002) Verbal and spatial working memory performance among HIV-infected adults. J Int Neuropsychol Soc 8:532–538CrossRefPubMed

Kellogg SH, McHugh PF, Bell K, Schluger JH, Schluger RP, LaForge KS, Ho A, Kreek MJ (2003) The Kreek–McHugh–Schluger–Kellogg scale: a new, rapid method for quantifying substance abuse and its possible applications. Drug Alcohol Depend 69:137–150CrossRefPubMed

Keutmann MK, Gonzalez R, Maki PM, Rubin LH, Vassileva J, Martin EM (2016) Sex differences in HIV effects on visual memory among substance-dependent individuals. J Clin Exp Neuropsychol 15:1–3

Kuo I, Greenberg AE, Magnus M, Phillips G, Rawls A, Peterson J, Hamilton F, West-Ojo T, Hader S (2011) High prevalence of substance use among heterosexuals living in communities with high rates of AIDS and poverty in Washington, DC. Drug Alcohol Depend 117:139–144CrossRefPubMed

Lashomb AL, Vigorito M, Chang SL (2009) Further characterization of the spatial learning deficit in the human immunodeficiency virus-1 transgenic rat. J NeuroVirol 15:14–24

Letendre S, Marquie-Beck J, Capparelli E, Best B, Clifford D, Collier AC, Gelman BB, McArthur JC, McCutchan JA, Morgello S, Simpson D (2008) Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system. Arch Neurol 65:65–70CrossRefPubMedPubMedCentral

Levenson MR, Kiehl KA, Fitzpatrick CM (1995) Assessing psychopathic attributes in a noninstitutionalized population. J Pers Soc Psychol 168:151CrossRef

Maeda Y, Yoon SY (2013) A meta-analysis on gender differences in mental rotation ability measured by the Purdue spatial visualization tests: visualization of rotations (PSVT: R). Educ Psychol Rev 25:69–94CrossRef

Maki PM, Cohen MH, Weber K, Little DM, Fornelli D, Rubin LH, Perschler P, Gould F, Martin E (2009) Impairments in memory and hippocampal function in HIV-positive vs HIV-negative women a preliminary study. Neurology 72:1661–1668CrossRefPubMedPubMedCentral

Maki PM, Rubin LH, Valcour V, Martin E, Crystal H, Young M, Weber KM, Manly J, Richardson J, Alden C, Anastos K (2015) Cognitive function in women with HIV findings from the Women’s Interagency HIV Study. Neurology 84:231–240CrossRefPubMedPubMedCentral

Manly JJ, Smith C, Crystal HA, Richardson J, Golub ET, Greenblatt R, Robison E, Martin EM, Young M (2011) Relationship of ethnicity, age, education, and reading level to speed and executive function among HIV+ and HIV–women: the Women’s Interagency HIV Study (WIHS) Neurocognitive Substudy. J Clin Exp Neuropsychol 33:853–863CrossRefPubMedPubMedCentral

Martin A (1994) HIV, cognition and the basal ganglia. In: Grant I, Martin A (eds) Neuropsychology of HIV infection. Oxford University Press, New York, pp 234–259

Martin E, Gonzalez R, Vassileva J, Maki P (2011) HIV+ men and women show different performance patterns on procedural learning tasks. J Clin Exp Neuropsychol 33:112–120CrossRefPubMed

Martin-Thormeyer EM, Paul RH (2009) Drug abuse and hepatitis C infection as comorbid features of HIV associated neurocognitive disorder: neurocognitive and neuroimaging features. Neuropsychol Rev 19:215–231CrossRefPubMedPubMedCentral

McLellan AT, Luborsky L, Woody GE, O'Brien CP (1980) An improved diagnostic evaluation instrument for substance abuse patients: the Addiction Severity Index. J Nerv Ment Dis 168:26–33CrossRefPubMed

Meyer VJ, Rubin LH, Martin E, Weber KM, Cohen MH, Golub ET, Valcour V, Young MA, Crystal H, Anastos K, Aouizerat BE (2013) HIV and recent illicit drug use interact to affect verbal memory in women. J Acquir Immune Defic Syndr 63:67CrossRefPubMedPubMedCentral

Meyer VJ, Little DM, Fitzgerald DA, Sundermann EE, Rubin LH, Martin EM, Weber KM, Cohen MH, Maki PM (2014) Crack cocaine use impairs anterior cingulate and prefrontal cortex function in women with HIV infection. J Neuro-Virol 20:352–361

Moffat SD, Hampson E, Hatzipantelis M (1998) Navigation in a “virtual” maze: sex differences and correlation with psychometric measures of spatial ability in humans. Evol Hum Behav 19:73–87CrossRef

Moore DJ, Masliah E, Rippeth JD, Gonzalez R, Carey CL, Cherner M, Ellis RJ, Achim CL, Marcotte TD, Heaton RK, Grant I (2006) Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment. AIDS 20:879–887CrossRefPubMed

Morales D, Acevedo SF, Skolasky RL, Hechavarria R, Santiago S, De La Torre T, Maldonado E, Wojna V (2012) Translational spatial task and its relationship to HIV-associated neurocognitive disorders and apolipoprotein E in HIV-seropositive women. J Neuro-Virol 18:488–502

Morgan EE, Woods SP, Weber E, Dawson MS, Carey CL, Moran LM, Grant I (2009) HIV-associated episodic memory impairment: evidence of a possible differential deficit in source memory for complex visual stimuli. J Neuropsychiatry Clin Neurosci 21:189–198CrossRefPubMedPubMedCentral

Murji S, Rourke SB, Donders J, Carter SL, Shore D, Rourke BP (2003) Theoretically derived CVLT subtypes in HIV-1 infection: internal and external validation. J Int Neuropsychol Soc 9:1–6CrossRefPubMed

Piper BJ, Acevedo SF, Edwards KR, Curtiss AB, McGinnis GJ, Raber J (2011) Age, sex, and handedness differentially contribute to neurospatial function on the Memory Island and Novel-Image Novel-Location tests. Physiol Behav 103:513–522CrossRefPubMedPubMedCentral

Redish AD, Touretzky DS (1998) The role of the hippocampus in solving the Morris water maze. Neural Comput 10:73–111

Reger M, Welsh R, Razani J, Martin DJ, Boone KB (2002) A meta-analysis of the neuropsychological sequelae of HIV infection. JINS 8:410–424PubMed

Rizk-Jackson AM, Acevedo SF, Inman D, Howieson D, Benice TS, Raber J (2006) Effects of sex on object recognition and spatial navigation in humans. Behav Brain Res 173:181–190CrossRefPubMed

Sanchez-Alavez M, Criado J, Gómez-Chavarín M, Jimenez-Anguiano A, Navarro L, Díaz-Ruiz O, Galicia O, Sanchez-Narvaez F, Murillo-Rodríguez E, Henriksen SJ, Elder JH (2000) HIV-and FIV-derived gp120 alter spatial memory, LTP, and sleep in rats. Neurobiol Dis 7:384–394CrossRefPubMed

Smurzynski M, Wu K, Letendre S, Robertson K, Bosch RJ, Clifford DB, Evans S, Collier AC, Taylor M, Ellis R (2011) Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort. AIDS 25:357CrossRefPubMedPubMedCentral

Stein MA, Sandoval R, Szumowski E, Roizen N, Reinecke MA, Blondis TA, Klein Z (1995) Psychometric characteristics of the Wender Utah Rating Scale (WURS): reliability and factor structure for men and women. Psychopharmacol Bull 31:425–433PubMed

Thompson PM, Dutton RA, Hayashi KM, Toga AW, Lopez OL, Aizenstein HJ, Becker JT (2005) Thinning of the cerebral cortex visualized in HIV/AIDS reflects CD4+ T lymphocyte decline. Proc Natl Acad Sci U S A 102:15647–15652CrossRefPubMedPubMedCentral

Vigorito M, LaShomb AL, Chang SL (2007) Spatial learning and memory in HIV-1 transgenic rats. J NeuroImmune Pharmacol 2:319–328CrossRefPubMed

Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848–858CrossRefPubMedPubMedCentral

Wechsler D (2001) Wechsler test of adult reading: WTAR. Psychological Corporation, San Antonio

Woods SP, Scott JC, Sires DA, Grant I, Heaton RK, Tröster AI, HIV Neurobehavioral Research Center (HNRC) Group (2005) Action (verb) fluency: test–retest reliability, normative standards, and construct validity. J Int Neuropsychol Soc 11:408–415PubMed

Woods SP, Moore DJ, Weber E, Grant I (2009) Cognitive neuropsychology of HIV-associated neurocognitive disorders. Neuropsychol Rev 19:152–168CrossRefPubMedPubMedCentral

Titel: Effects of sex and HIV serostatus on spatial navigational learning and memory among cocaine users
verfasst von: J. Fogel
L. H. Rubin
P. Maki
M. K. Keutmann
R. Gonzalez
J. Vassileva
E. M. Martin
Publikationsdatum: 28.08.2017
Verlag: Springer International Publishing
Erschienen in: Journal of NeuroVirology / Ausgabe 6/2017
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0563-7

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