Acknowledgements
The authors acknowledge Lisa Klumpp, PhD, Cynthia Gobbel, PhD, and Lisa Feder, PhD, from Scientific Connexions (Newtown, PA, USA) for writing assistance funded by AstraZeneca LP, the study sponsor, which designed the study and participated in the management, analysis and interpretation of the data, and in the review and approval of the article. Dr Tashkin has served as a consultant for AstraZeneca, Boehringer-Ingelheim, Dey Laboratories and Schering-Plough; received honoraria from AstraZeneca, Boehringer-Ingelheim and Dey Laboratories; and received or will receive grants from Almirall, AstraZeneca, Boehringer-Ingelheim, Dey Laboratories, Novartis, Pfizer, Sepracor and Forest Laboratories. Dr Rennard has served as a consultant or on the advisory board for Adams, Almirall, Altana, AstraZeneca, Bend, Biolipox, Centocor, Critical Therapeutics, Dey Laboratories, GlaxoSmithKline, ICOS, Johnson & Johnson, Novartis, Ono Pharma, Perengenix, Pfizer, Roche, Sankyo, Sanofi, Schering-Plough and Talecris; has served as a speaker for AstraZeneca, Boehringer-Ingelheim, GlaxoSmithKline, Otsuka and Pfizer; and has received grants from Almirall, Altana, Astellas, Centocor, GlaxoSmithKline, Nabi, Novartis and Pfizer. Drs Martin, Ramachandran and Goldman and Ms Martin are current employees of AstraZeneca LP and own stock or stock options in AstraZeneca LP. Dr Silkoff is a former employee of AstraZeneca LP.
Investigator List
We thank the following investigators for their participation in the study: René Aalbers, Groningen, the Netherlands; Constantia Abarikwu, Phoenix, AZ, USA; Ishmael Abdullah, Cape Town, South Africa; John Adams, Houston, TX, USA; Jay Adler, Colorado Springs, CO, USA; Tahir Ahmed, Miami Beach, FL, USA; Charles Anderson, Bay Pines, FL, USA; Beata Asankowicz-Bargiel, Ostrow Wielkopolski, Poland; Theo Bantje, Breda, the Netherlands; Halina Batura-Gabryel, Poznan, Poland; George Bensch, Stockton, CA, USA; Henk Berendsen, Den Haag, the Netherlands; William Berger, Mission Viejo, CA, USA; Gary Berman, Plymouth, MN, USA; David Bernstein, Cincinnati, OH, USA; Eugene Bleecker, Winston-Salem, NC, USA; R Block, Terneuzen, the Netherlands; David Boerner, Raleigh, NC, USA; Vinko Bogdanic, Waterloo, IA, USA; Christoph Bolliger, Parow, South Africa; Jerzy Bortkiewicz, Ilawa, Poland; Joseph Boscia, Gaffney, SC, USA; Wesley Bray, Marietta, GA, USA; Shari Brazinsky, San Diego, CA, USA; Walter Dwayne Brown, Lafayette, LA, USA; Krzysztof Brzecki, Turek, Poland; Wissam Chatila, Philadelphia, PA, USA; Kenneth Chinsky, Erie, PA, USA; Teresa Coats, Austin, TX, USA; Stephen Cohen, San Antonio, TX, USA; Gordon Connor, Birmingham, AL, USA; Clinton Corder, Oklahoma City, OK, USA; Henry Covelli, Coeur d’Alene, ID, USA; Jacques Creemers, Eindhoven, the Netherlands; Malgorzata Czajkowska-Malinowska, Bydgoszcz, Poland; Joel Diamond, Pittsburgh, PA, USA; Jan Dindos, Neratovice, Czech Republic; Malgorzata Dobryniewska, Gorzow Wielkopolski, Poland; James Donohue, Chapel Hill, NC, USA; Leonard Dunn, Clearwater, FL, USA; Vincent Duurkens, Nieuwegein, the Netherlands; Andrzej Dymek, Zawadzkie, Poland; David Elkayam, Bellingham, WA, USA; Steven Elliott, Evansville, IN, USA; Ingrid Engelbrecht, Pretoria, South Africa; David Erb, Union, SC, USA; Neil Ettinger, Chesterfield, MO, USA; Richard Fei, Lafayette, LA, USA; Barry Feinstein, Richmond, VA, USA; Gregory Feldman, Spartanburg, SC, USA; Charles Fogarty, Spartanburg, SC, USA; Linda Ford, Papillion, NE, USA; Eva Fridrichovska, Praha, Czech Republic; Ashok Fulambarker, Chicago, IL, USA; William Gamel, Austin, TX, USA; Steven Gans, Harderwijk, the Netherlands; Stuart Garay, New York, NY, USA; Adam Gawron, Sopot, Poland; Sherwin Gillman, Orange, CA, USA; Ronald Gilman, Providence, RI, USA; Mark Gotfried, Glendale, AZ, USA; Gregory Gottschlich, Cincinnati, OH, USA; Nicolas Gross, Hines, IL, USA; Elena Guttlerova, Praha, Czech Republic; Martin Hadrava, Cvikov, Czech Republic; Nicola Hanania, Houston, TX, USA; Rafal Harat, Chrzanow, Poland; Milos Havlik, Znojmo, Czech Republic; Vernon Hershberger, Akron, OH, USA; Robert Hewlett, Irvine, CA, USA; David Hill, Westbury, CT, USA; Ira Horowitz, Cherry Hill, NJ, USA; Gary Hunt, Blue Ridge, GA, USA; Sean Hurley, Spokane, WA, USA; Thomas Hyers, St Louis, MO, USA; Jonathan Ilowite, Mineola, NY, USA; Elvis Irusen, Parow, South Africa; Dirkie Jansen Van Rensburg, Witbank, South Africa; Malgorzata Jedrzejczak, Checiny, Poland; Viktor Jensovsky, Lovosice, Czech Republic; David Johnson, Searcy, AR, USA; Glen Journeay, Austin, TX, USA; Tomasz Kachel, Bystra Slaska, Poland; Richard Kahn, Auburn, ME, USA; Piotr Kaminski, Lublin, Poland; Mitchell Kaye, Minneapolis, MN, USA; Edwin Kerwin, Medford, OR, USA; Walter Kleinsteuber, Louisville, KY, USA; Steven Koenig, Charlottesville, VA, USA; Vitezslav Kolek, Olomouc, Czech Republic; Phillip Korenblat, St Louis, MO, USA; Luke Krige, Port Elizabeth, South Africa; Peter Krumpe, Reno, NV, USA; Piotr Kuna, Lodz, Poland; Ritsu Kuno, Richmond, VA, USA; Deepak Lakha, Lenasia, South Africa; David Laman, Jefferson Hills, PA, USA; Tadeusz Latos, Karpacz, Poland; Michael Lawrence, Taunton, MA, USA; Thomas Lemire, Missoula, MT, USA; Wlodzimierz Leszczynski, Gidle, Poland; Bernard Levine, Phoenix, AZ, USA; Michael Littner, Sepulveda, CA, USA; Halina Lupinska, Lomza, Poland; Dorota Malosek, Szczecin, Poland; Michael Mandel, Larchmont, NY, USA; Ebrahim Manuel, Cape Town, South Africa; Jaroslav Mares, Strakonice, Czech Republic; Gregory Mason, Torrance, CA, USA; Dennis McCluskey, Mogadore, OH, USA; Charlene McEvoy, Minneapolis, MN, USA; Barbara McGuire, Albuquerque, NM, USA; Arturo Meade, Fort Smith, AR, USA; Isaac Melamed, Centennial, CO, USA; Mark Millard, Dallas, TX, USA; Brian Miller, Killeen, TX, USA; Martin Mollen, Phoenix, AZ, USA; Timothy Moriarty, Panama City, FL, USA; Piotr Nalepa, Krakow, Poland; Anjuli Nayak, Normal, IL, USA; Heylene Nell, Cape Town, South Africa; Harold Nelson, Denver, CO, USA; Artur Niemiec, Krakow, Poland; Grant Nieuwoudt, Cape Town, South Africa; Michael Noonan, Portland, OR, USA; Marzena Okninska-Wasiak, Siedlce, Poland; Robert Onder Jr, St Louis, MO, USA; Trevenesan Padayachee, Umkomaas, South Africa; Parimal Parikh, New Orleans, LA, USA; Amit Patel, Riverside, CA, USA; Hana Paukova, Kladno, Czech Republic; James Pearle, Fullerton, CA, USA; Andrew Pedinoff, Skillman, NJ, USA; Piotr Piskorz, Wolomin, Poland; Martin Polasek, Ostrava, Czech Republic; Alexandra Popelkova, Beroun, Czech Republic; Jolana Presperinova, Liberec, Czech Republic; Anna Prokop-Staszecka, Krakow, Poland; Krishna Pudi, Simpsonville, SC, USA; Albert Razzetti, DeLand, FL, USA; Marcin Regulski, Otwock, Poland; Pavel Reiterer, Usti nad Labem, Czech Republic; Dennis Riff, Anaheim, CA, USA; Emory Robinette, Abingdon, VA, USA; Cesar Rodarte, Mesa, AZ, USA; Jonathan Rosen, Bristol, CT, USA; Ingrid J. Roux, Cape Town, South Africa; Cezary Rybacki, Bydgoszcz, Poland; Steven Sahn, Charleston, SC, USA; Gilbert Salazar, San Antonio, TX, USA; Jana Satinska, Ostrava, Czech Republic; Eric Schenkel, Easton, PA, USA; Noel Schlösser, Utrecht, the Netherlands; Nathan Schultz, Walnut Creek, CA, USA; Frank Sciurba, Pittsburgh, PA, USA; Peter Sebastian, Durban, South Africa; William Seger, Fort Worth, TX, USA; Allan Seibert IV, Mobile, AL, USA; Sanjay Sethi, Buffalo, NY, USA; Paul Shapero, Bangor, ME, USA; Amir Sharafkhaneh, Houston, TX, USA; Mandy Shaw, Omaha, NE, USA; John Sibille, Sunset, LA, USA; Thomas Siler, St. Charles, MO, USA; Howard Silverboard, Atlanta, GA, USA; Wayne Sinclair, Missoula, MT, USA; Baldev Singh, Pembroke Pines, FL, USA; Henk Sinninghe-Damsté, Almelo, the Netherlands; Emil Skobeloff, Ridley Park, PA, USA; Wojciech Skucha, Proszowice, Poland; Pawel Sliwinski, Warszawa, Poland; Cezary Sosnowski, Bialystok, Poland; John Southard, Council Bluffs, IA, USA; Paul Staab, Marrero, LA, USA; William Stein, Rochester, NY, USA; Mary Strek, Chicago, IL, USA; Luba Strouhova, Kutna Hora, Czech Republic; Clement Strumillo, Las Vegas, NV, USA; Robert Sussman, Summit, NJ, USA; Wojciech Szafranski, Radom, Poland; Martha Tarpay, Oklahoma City, OK, USA; James Taylor, Tacoma, WA, USA; Wanda Terlecka, Czestochowa, Poland; Diego Torres II, Ormond Beach, FL, USA; Stephen Ulrich, Zanesville, OH, USA; Marjo Van De Ven, Arnhem, the Netherlands; Jan Van Noord, Heerlen, the Netherlands; Josef Veverka, Rokycany, Czech Republic; Vladimir Vondra, Praha, Czech Republic; John Weiler, Iowa City, IA, USA; Jan Westerman, Jasper, AL, USA; John Winder, Sylvania, OH, USA; Bret Wittmer, Madisonville, KY, USA; Gary Wohlberg, Bay Shore, NY, USA; Robert Wolfe, Los Angeles, CA, USA; James Wolfe, San Jose, CA, USA; Magdalena Zalecka, Poznan, Poland; Petr Zatloukal, Praha, Czech Republic; Vladimir Zindr, Karlovy Vary, Czech Republic; Dariusz Ziora, Zabrze, Poland; Malgorzata Zurowska-Gebala, Tarnow, Poland.