Skip to main content
Erschienen in: Heart and Vessels 2/2018

16.08.2017 | Original Article

Efficacy and safety of the early use of V2 receptor antagonists in elderly patients with decompensated heart failure

verfasst von: Ryuichi Matsukawa, Toru Kubota, Masanori Okabe, Yusuke Yamamoto, Hiroshi Meno

Erschienen in: Heart and Vessels | Ausgabe 2/2018

Einloggen, um Zugang zu erhalten

Abstract

We recently reported that the early initiation of tolvaptan in congestive heart failure shortened the hospital stay and reduced the rate of in-hospital death. However, whether or not these results apply to elderly patients with congestive heart failure is unclear. We performed a sub-analysis of our previous study. Among the 102 patients in that study, we retrospectively analyzed the elderly patients >75 years of age treated with tolvaptan. First, we analyzed the efficacy of early tolvaptan use in these patients. We then compared the efficacy and the safety of all tolvaptan use between elderly and younger patients. There were no significant differences in the baseline clinical parameters between the early- and late-tolvaptan-use elderly patients, except for the serum blood nitrogen urea. However, the early use of tolvaptan was also associated with the earlier initiation of ambulatory cardiac rehabilitation, a shorter hospital stay, and a lower rate of in-hospital death in elderly congestive heart failure patients. Furthermore, there were no significant differences in the occurrence of worsening renal failure and hypernatremia. The early use of tolvaptan in elderly patients was also associated with a shorter hospital stay and reduced mortality. We also confirmed the safety of tolvaptan in elderly patients. It might, therefore, be beneficial to consider administering tolvaptan early in elderly patients with heart failure, just as in younger patients.
Literatur
1.
Zurück zum Zitat Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, Nodari S, Lam CS, Sato N, Shah AN, Gheorghiade M (2014) The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. JACC 63(12):1123–1133CrossRefPubMed Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, Nodari S, Lam CS, Sato N, Shah AN, Gheorghiade M (2014) The global health and economic burden of hospitalizations for heart failure: lessons learned from hospitalized heart failure registries. JACC 63(12):1123–1133CrossRefPubMed
2.
Zurück zum Zitat Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL (2013) 2013 ACCF/AHA guideline for the management of heart failure. JACC 62(16):e147–e239CrossRefPubMed Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE Jr, Drazner MH, Fonarow GC, Geraci SA, Horwich T, Januzzi JL, Johnson MR, Kasper EK, Levy WC, Masoudi FA, McBride PE, McMurray JJ, Mitchell JE, Peterson PN, Riegel B, Sam F, Stevenson LW, Tang WH, Tsai EJ, Wilkoff BL (2013) 2013 ACCF/AHA guideline for the management of heart failure. JACC 62(16):e147–e239CrossRefPubMed
3.
Zurück zum Zitat Fonarow GC, Heywood JT, Heidenreich PA, Lopatin M, Yancy CW (2007) Temporal trends in clinical characteristics, treatments, and outcomes for heart failure hospitalizations, 2002–2004: findings from Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 153(6):1021–1028CrossRefPubMed Fonarow GC, Heywood JT, Heidenreich PA, Lopatin M, Yancy CW (2007) Temporal trends in clinical characteristics, treatments, and outcomes for heart failure hospitalizations, 2002–2004: findings from Acute Decompensated Heart Failure National Registry (ADHERE). Am Heart J 153(6):1021–1028CrossRefPubMed
4.
Zurück zum Zitat Blecker S, Paul M, Taksler G, Ogedegbe G, Katz S (2013) Heart failure-associated hospitalizations in the United States. JACC 61(12):1259–1267CrossRefPubMed Blecker S, Paul M, Taksler G, Ogedegbe G, Katz S (2013) Heart failure-associated hospitalizations in the United States. JACC 61(12):1259–1267CrossRefPubMed
5.
Zurück zum Zitat Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A (2007) Characteristics and outcomes of patients with heart failure in general practices and hospitals—Japanese Cardiac Registry of Heart Failure in General Practice (JCARE-GENERAL)-. Circ J 71(4):449–454CrossRefPubMed Tsutsui H, Tsuchihashi-Makaya M, Kinugawa S, Goto D, Takeshita A (2007) Characteristics and outcomes of patients with heart failure in general practices and hospitals—Japanese Cardiac Registry of Heart Failure in General Practice (JCARE-GENERAL)-. Circ J 71(4):449–454CrossRefPubMed
6.
Zurück zum Zitat Sato N, Kajimoto K, Asai K, Mizuno M, Minami Y, Nagashima M, Murai K, Muanakata R, Yumino D, Meguro T, Kawana M, Nejima J, Satoh T, Mizuno K, Tanaka K, Kasanuki H, Takano T (2010) Acute decompensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: rationale, design, and preliminary data. Am Heart J 159(6):949–955CrossRefPubMed Sato N, Kajimoto K, Asai K, Mizuno M, Minami Y, Nagashima M, Murai K, Muanakata R, Yumino D, Meguro T, Kawana M, Nejima J, Satoh T, Mizuno K, Tanaka K, Kasanuki H, Takano T (2010) Acute decompensated heart failure syndromes (ATTEND) registry. A prospective observational multicenter cohort study: rationale, design, and preliminary data. Am Heart J 159(6):949–955CrossRefPubMed
8.
Zurück zum Zitat Sato N, Kajimoto K, Keida T, Mizuno M, Minami Y, Yumino D, Asai K, Murai K, Muanakata R, Aokage T, Sakata Y, Mizuno K, Takano T (2013) Clinical features and outcome in hospitalized heart failure in Japan (from the ATTEND Registry). Circ J 77(4):944–951CrossRefPubMed Sato N, Kajimoto K, Keida T, Mizuno M, Minami Y, Yumino D, Asai K, Murai K, Muanakata R, Aokage T, Sakata Y, Mizuno K, Takano T (2013) Clinical features and outcome in hospitalized heart failure in Japan (from the ATTEND Registry). Circ J 77(4):944–951CrossRefPubMed
9.
Zurück zum Zitat Matsukawa R, Kubota T, Okabe M, Yamamoto Y (2016) Early use of V2 receptor antagonists is associated with a shorter hospital stay and reduction in in-hospital death in patients with decompensated heart failure. Heart Vessels 31(10):1650–1658CrossRefPubMed Matsukawa R, Kubota T, Okabe M, Yamamoto Y (2016) Early use of V2 receptor antagonists is associated with a shorter hospital stay and reduction in in-hospital death in patients with decompensated heart failure. Heart Vessels 31(10):1650–1658CrossRefPubMed
10.
Zurück zum Zitat Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transpl 48(3):452–458CrossRef Kanda Y (2013) Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics. Bone Marrow Transpl 48(3):452–458CrossRef
11.
Zurück zum Zitat Kinugawa K, Inomata T, Sato N, Yasuda M, Shimakawa T, Bando K, Mizuguchi K (2015) Effectiveness and adverse events of tolvaptan in octogenarians with heart failure. interim analyses of Samsca post-marketing surveillance in heart failure (SMILE study). Int Heart J 56(2):137–143CrossRefPubMed Kinugawa K, Inomata T, Sato N, Yasuda M, Shimakawa T, Bando K, Mizuguchi K (2015) Effectiveness and adverse events of tolvaptan in octogenarians with heart failure. interim analyses of Samsca post-marketing surveillance in heart failure (SMILE study). Int Heart J 56(2):137–143CrossRefPubMed
12.
Zurück zum Zitat Setoguchi M, Hashimoto Y, Sasaoka T, Ashikaga T, Isobe M (2015) Risk factors for rehospitalization in heart failure with preserved ejection fraction compared with reduced ejection fraction. Heart Vessels 30:595–603CrossRefPubMed Setoguchi M, Hashimoto Y, Sasaoka T, Ashikaga T, Isobe M (2015) Risk factors for rehospitalization in heart failure with preserved ejection fraction compared with reduced ejection fraction. Heart Vessels 30:595–603CrossRefPubMed
13.
Zurück zum Zitat Kazory Amor (2010) Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure. Am J Cardiol 106(5):694–700CrossRefPubMed Kazory Amor (2010) Emergence of blood urea nitrogen as a biomarker of neurohormonal activation in heart failure. Am J Cardiol 106(5):694–700CrossRefPubMed
Metadaten
Titel
Efficacy and safety of the early use of V2 receptor antagonists in elderly patients with decompensated heart failure
verfasst von
Ryuichi Matsukawa
Toru Kubota
Masanori Okabe
Yusuke Yamamoto
Hiroshi Meno
Publikationsdatum
16.08.2017
Verlag
Springer Japan
Erschienen in
Heart and Vessels / Ausgabe 2/2018
Print ISSN: 0910-8327
Elektronische ISSN: 1615-2573
DOI
https://doi.org/10.1007/s00380-017-1039-7

Weitere Artikel der Ausgabe 2/2018

Heart and Vessels 2/2018 Zur Ausgabe

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

26.04.2024 Mammografie Nachrichten

Routinemäßige Mammografien helfen, Brustkrebs frühzeitig zu erkennen. Anhand der Röntgenuntersuchung lassen sich aber auch kardiovaskuläre Risikopatientinnen identifizieren. Als zuverlässiger Anhaltspunkt gilt die Verkalkung der Brustarterien.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Adipositas-Medikament auch gegen Schlafapnoe wirksam

24.04.2024 Adipositas Nachrichten

Der als Antidiabetikum sowie zum Gewichtsmanagement zugelassene Wirkstoff Tirzepatid hat in Studien bei adipösen Patienten auch schlafbezogene Atmungsstörungen deutlich reduziert, informiert der Hersteller in einer Vorab-Meldung zum Studienausgang.

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.