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The journal of nutrition, health & aging

Erschienen in:

08.04.2016

Efficacy and therapeutic potential of curcumin against sepsis-induced chronic lung injury in male albino rats

verfasst von: Y.-F. Liu, C.-W. Yang, H. Liu, S.-G. Sui, Xiang-Dong Li

Erschienen in: The journal of nutrition, health & aging | Ausgabe 3/2017

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Abstract

The present study investigates curcumin effect against sepsis-induced chronic lung injury (CLI) of male albino rats. Rats were grouped into four groups such rats undergoing a sham cecal ligature puncture (CLP), rats undergoing CLP, rats undergoing CLP and treated with saline and rats undergoing CLP and treated with curcumin (100 mg/kg bwt). After 45 days of treatment, bronchoalveolar fluid (BALF), blood and lung tissues were collected from the each animal. The total protein content, wet and dry (W/D) weight of lung tissues and some inflammatory cells in the BALF were measured. Histopathological analysis was carried out to investigate the alteration of the cellular architecture of lung tissues. Lipid peroxidation malondialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) levels were determined. Cytokines such as interleukin-8 (IL- 8), tumor necrosis factor-alpha (TNF-a) and macrophage inhibitory factor (MIF) were measured in the BALF. Curcumin administration significantly reduced CLP-induced inflammation and pulmonary edema. Curcumin treatment is significantly reduced MPO activity, and inflammatory cell accumulation in the BALF and also protein level, MDA, SOD, and W/D ratio were significantly reduced in the lung tissues. Also, curcumin reduced the expression of IL-A, TNF-a and MIF levels in the lung tissues. Histopathological study revealed the significant reduction of CLP-induced CLI in the curcumin-treated male albino rats. Taking all these data together, it is concluded that curcumin can act as a suitable therapeutic agent against CLP-induced CLI of male albino rats.

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Titel: Efficacy and therapeutic potential of curcumin against sepsis-induced chronic lung injury in male albino rats
verfasst von: Y.-F. Liu
C.-W. Yang
H. Liu
S.-G. Sui
Xiang-Dong Li
Publikationsdatum: 08.04.2016
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 3/2017
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-016-0722-1

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