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23.10.2021 | Original Article

Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial

verfasst von: Jaime Gallo-Villegas, Leonardo A. Castro-Valencia, Laura Pérez, Daniel Restrepo, Oscar Guerrero, Sergio Cardona, Yeliana L. Sánchez, Manuela Yepes-Calderón, Luis H. Valbuena, Miguel Peña, Andrés F. Milán, Maria C. Trillos-Almanza, Sergio Granados, Juan C. Aristizabal, Mauricio Estrada-Castrillón, Raúl Narvaez-Sanchez, Jorge Osorio, Daniel C. Aguirre-Acevedo, Juan C. Calderón

Erschienen in: European Journal of Applied Physiology | Ausgabe 2/2022

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Abstract

Purpose

We carried out a randomized, clinical trial in adults of both sexes with metabolic syndrome (MS) to assess the efficacy of high-intensity, low-volume interval training (HIIT) compared to moderate-intensity continuous training (MICT) on insulin resistance (IR), muscle mass, muscle activation, and serum musclin.

Methods

Fasting glycemia, insulinemia, and glycated haemoglobin were determined by conventional methods, IR by Homeostatic model assessment (HOMA), lean mass by Dual-Energy X-ray Absorptiometry, muscle activation through carnosine by Proton Magnetic Resonance Spectroscopy, and musclin by Enzyme-Linked ImmunoSorbent Assay before and after a supervised, three-times/week, 12-week treadmill programme. HIIT (n = 29) consisted of six intervals with one-minute, high-intensity phases at 90% of peak oxygen consumption (VO_2peak). MICT (n = 31) trained at 60% of VO_2peak for 30 min.

Results

Patients had a mean age of 50.8 ± 6.0 years, body mass index of 30.6 ± 4.0 kg/m², and VO_2peak of 29.0 ± 6.3 mL.kg⁻¹.min⁻¹. Compared to MICT, HIIT was not superior at reducing Ln HOMA-IR (adjusted mean difference: 0.083 [95%CI − 0.092 to 0.257]), carnosine or musclin or at increasing thigh lean mass. HIIT increased carnosine by 0.66 mmol/kg.ww (95% CI 0.08–1.24) after intervention. Both interventions reduced IR, body fat percentage and increased total lean mass/height² and VO_2peak. Musclin showed a non-significant reduction with a small effect size after both interventions.

Conclusion

Compared to MICT, HIIT is not superior at reducing IR, carnosine or musclin or at increasing skeletal muscle mass in adults with MS. Both training types improved IR, muscle mass and body composition. NCT03087721, March 22nd, 2017.

Trial registration number

NCT03087721. Registered March 22nd, 2017.

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Titel: Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial
verfasst von: Jaime Gallo-Villegas
Leonardo A. Castro-Valencia
Laura Pérez
Daniel Restrepo
Oscar Guerrero
Sergio Cardona
Yeliana L. Sánchez
Manuela Yepes-Calderón
Luis H. Valbuena
Miguel Peña
Andrés F. Milán
Maria C. Trillos-Almanza
Sergio Granados
Juan C. Aristizabal
Mauricio Estrada-Castrillón
Raúl Narvaez-Sanchez
Jorge Osorio
Daniel C. Aguirre-Acevedo
Juan C. Calderón
Publikationsdatum: 23.10.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Applied Physiology / Ausgabe 2/2022
Print ISSN: 1439-6319
Elektronische ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-021-04835-w

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Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Efficacy of high-intensity interval- or continuous aerobic-training on insulin resistance and muscle function in adults with metabolic syndrome: a clinical trial

Abstract

Purpose

Methods

Results

Conclusion

Trial registration number

Neu im Fachgebiet Arbeitsmedizin

Das Geschlechterparadoxon in der gesundheitlich beeinträchtigten Lebenszeit – Ende eines Mythos?

Gesunde Lebenserwartung: Ein kritischer Blick auf Nutzen und Potenziale des demographischen Gesundheitsindikators

Wie hat sich die Lebenserwartung ohne funktionelle Einschränkungen in Deutschland entwickelt? Eine Analyse mit Daten des Deutschen Alterssurveys (DEAS)

Hitzeschutz im Fokus der hessischen Betreuungs- und Pflegeaufsicht

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Trial registration number

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