Efficacy of nano-zinc on skin and wool repair of treated cases of mange in sheep

Mange in sheep is still results in serious economic problems the most one is losses of hid and wool. This requires not only treatment of primary disease but also rapid repairing of skin and wool. The most effective trace element helps the regeneration of skin and wool is zinc. The present study aimed to evaluate the efficacy of nano−zinc supplementation in reducing the time required to recovery and complete skin repair and wool regrowth during treatment of Psoroptic mange in sheep. Forty male Rahmani sheep were divided into four groups each one contained ten sheep. The first group was clinically healthy (CH) and the other three groups were clinically suffered from mange and divided according to treatment into nano-zinc (NZ) group which received doramectin injection plus nano-zinc orally, mineral mixture (MM) group which received doramectin injection plus mineral mixture orally, and DM group which injected by doramectin only. All animals were subjected to keen clinical and confirmative examination and criteria of recovery were routinely assessed day after day. Assessment of skin and wool repair as well as the serum samples were collected for analyses before treatment; at 0 day then at 15th and 30th days after treatment. The clinical examination revealed gradual recovery of clinical signs, and 3 days after treatment the signs of pruritis decreased and disappeared after 1 week. The lesions reduced in size toward the center with regrowth of wool from repaired peripheries of lesions. The assessment of skin and wool repair and biochemical constituents revealed rapid repaired lesions at the 15th day of treatment in NZ group, while MM and DM groups started to be recovered at the 30th day of treatment. Serum biochemical analyses revealed significant decrease in serum zinc, hyperproteinemia, hypoalbuminemia, and hyperglobulinemia and significantly decreased of ALP, AST, γ-GT, and LDH activities with significantly increased serum creatinine in NZ, MM, and DM groups before treatment. Most of these serum changes showed non-significant changes at the 15th day of treatment in NZ group compared to CH group. However, MM group began to improve after 15th day of treatment and in some parameters extended to the 30th day of treatment, while DM group restored majority of estimated parameters at the 30th day of treatment when compared to CH group. In conclusion, nano-zinc supplementation during treatment of Psoroptic mange in sheep provides more effective and rapid regeneration and repair of skin tissues and wool rather than doramectin injection alone or with zinc oxide supplementation.