Background
Materials and methods
General
213Bi labelling
Stability studies
Results
c [μM] | DOTP | DOTPH | DOTPOEt | DOTPI | CHX-A"-DTPA | DOTA |
---|---|---|---|---|---|---|
100 | 92.9 ± 5.6 | 91.6 ± 0.4 | 79.6 ± 3.6 | 84.8 ± 4.0 | 91.4 ± 5.1 | 61.0 ± 7.3 |
30 | 88.8 ± 10.7 | 83.8 ± 11.9 | 70.8 ± 8.8 | 70.6 ± 11.9 | 78.6 ± 6.9 | 37.4 ± 6.9 |
10 | 87.2 ± 11.8 | 82.5 ± 12.4 | 70.6 ± 6.5 | 61.5 ± 5.1 | 75.7 ± 11.8 | 15.6 ± 6.7 |
3 | 86.5 ± 11.2 | 80.4 ± 9.7 | 66.0 ± 9.5 | 58.1 ± 2.4 | 75.3 ± 12.6 | 11.2 ± 0.9 |
1 | 89.3 ± 7.2 | 78.4 ± 10.6 | 63.5 ± 11.2 | 47.9 ± 2.6 | 66.6 ± 20.6 | 5.1 ± 4.6 |
0.3 | 85.4 ± 2.5 | 75.0 ± 14.8 | 56.0 ± 9.9 | 27.0 ± 2.0 | 41.5 ± 8.5 | |
0.1 | 85.0 ± 5.2 | 66.7 ± 3.1 | 42.4 ± 13.2 | 15.4 ± 9.5 | 22.1 ± 10.1 | |
0.03 | 67.6 ± 3.5 | 42.2 ± 2.8 | 27.5 ± 11.2 | 11.8 ± 3.5 | ||
0.01 | 32.4 ± 4.6 | 20.2 ± 5.7 | 16.7 ± 6.4 | |||
0.003 | 13.6 ± 4.1 | 3.8 ± 0.9 | 6.6 ± 3.5 | |||
0.001 | 4.3 ± 1.6 | 0.9 ± 1.3 |
c [μM] | DOTP | DOTPH | DOTPOEt | DOTPI | CHX-A"-DTPA | DOTA |
---|---|---|---|---|---|---|
100 | 99.4 ± 0.3 | 98.7 ± 2.1 | 99.1 ± 0.1 | 99.7 ± 0.3 | 99.8 ± 0.1 | 96.9 ± 3.6 |
30 | 98.6 ± 0.9 | 99.0 ± 0.2 | 99.0 ± 1.0 | 98.8 ± 0.3 | 96.8 ± 2.4 | 94.3 ± 2.6 |
10 | 96.4 ± 2.3 | 99.1 ± 0.7 | 98.3 ± 0.9 | 94.2 ± 4.2 | 91.9 ± 1.9 | 81.1 ± 9.0 |
3 | 94.3 ± 2.1 | 92.7 ± 2.5 | 96.4 ± 0.6 | 92.9 ± 4.8 | 89.2 ± 6.9 | 64.1 ± 21.4 |
1 | 91.8 ± 4.0 | 85.4 ± 2.6 | 95.9 ± 0.3 | 88.0 ± 10.8 | 90.2 ± 6.6 | 37.4 ± 17.5 |
0.3 | 90.6 ± 3.9 | 79.7 ± 4.7 | 94.7 ± 0.7 | 73.6 ± 29.0 | 82.7 ± 5.3 | 14.6 ± 6.1 |
0.1 | 90.9 ± 3.2 | 79.0 ± 2.5 | 93.7 ± 2.6 | 31.7 ± 17.1 | 49.7 ± 23.1 | 3.8 ± 2.8 |
0.03 | 90.4 ± 4.5 | 72.0 ± 5.4 | 85.7 ± 3.9 | 20.2 ± 9.4 | 9.8 ± 9.2 | |
0.01 | 89.5 ± 1.0 | 61.8 ± 8.7 | 66.2 ± 5.8 | 6.5 ± 4.7 | ||
0.003 | 56.2 ± 6.1 | 37.3 ± 5.5 | 10.5 ± 3.7 | |||
0.001 | 5.3 ± 4.2 | 0.4 ± 0.6 | 2.5 ± 0.7 |
medium | t [min] | DOTP | DOTPH | DOTPOEt | DOTPI | CHX-A"-DTPA | DOTA |
---|---|---|---|---|---|---|---|
DTPA | 30 | 97.3 ± 0.9 | 98.1 ± 0.8 | 94.6 ± 1.3 | 93.5 ± 0.6 | 92.5 ± 1.1 | 91.1 ± 2.4 |
DTPA | 60 | 87.0 ± 7.9 | 87.1 ± 7.7 | 86.8 ± 6.3 | 83.3 ± 3.9 | 82.7 ± 8.1 | 83.4 ± 9.0 |
DTPA | 120 | 69.9 ± 4.5 | 73.4 ± 1.2 | 71.0 ± 4.6 | 72.3 ± 5.4 | 55.6 ± 2.2 | 64.1 ± 2.1 |
Plasma | 60 | 98.4 ± 1.6 | 99.2 ± 0.5 | 98.8 ± 0.8 | 95.6 ± 1.9 | 90.8 ± 4.6 | 96.1 ± 4.0 |
Plasma | 120 | 96.4 ± 1.3 | 97.0 ± 1.8 | 97.2 ± 1.9 | 91.1 ± 7.1 | 76.3 ± 9.4 | 85.4 ± 4.3 |