nach oben

Digestive Diseases and Sciences

Erschienen in:

01.08.2006 | Original Paper

Electroacupuncture Elicits Dual Effects: Stimulation of Delayed Gastric Emptying and Inhibition of Accelerated Colonic Transit Induced by Restraint Stress in Rats

verfasst von: Masahiro Iwa, Yukiomi Nakade, Theodore N. Pappas, Toku Takahashi

Erschienen in: Digestive Diseases and Sciences | Ausgabe 8/2006

Einloggen, um Zugang zu erhalten

Abstract

Acupuncture has been used for treating functional gastrointestinal (GI) disorders. Animal studies have demonstrated that acupuncture antagonized various stress-induced responses. We investigated the effects of electroacupuncture (EA) at ST-36 (Zusanli; lower limb) on stress-induced alteration of GI motor activities. Solid gastric emptying was significantly delayed by restraint stress (29.6±2.4%; n=7) compared to that of controls (60.0±2.5%; n=8). Delayed gastric emptying was significantly improved by EA at ST-36 (47.2±1.8%). Intracisternal (IC) injection of corticotropin releasing factor (CRF; 1 μg) delayed gastric emptying to 25.4±3.1%, which was also improved by EA at ST-36, to 53.0±7.1% (n=8). The stimulatory effect of EA on stress-induced delayed gastric emptying was abolished by atropine (17.6±1.9%) but not by guanethidine (42.2±2.3%). Colonic transit was significantly accelerated by restraint stress (GC=7.2±0.3; n=8) compared to that of controls (GC=5.2±0.2; n=8). Accelerated colonic transit was significantly reduced by EA at ST-36 (GC=4.9±0.3). IC injection of CRF accelerated colonic transit (GC=6.9±0.2), which was also normalized by EA at ST-36 (GC=4.7±0.2). The inhibitory effect of EA on stress-induced acceleration of colonic transit was not affected by guanethidine (GC=4.6±0.3). In conclusion, EA at ST-36 showed dual effects: stimulation of stress-induced delayed gastric emptying and inhibition of stress-induced acceleration of colonic transit. The stimulatory effect of EA on stress-induced delayed gastric emptying is mediated via cholinergic pathways. The inhibitory effect of EA on stress-induced acceleration of colonic transit is independent of the sympathetic pathway.

Monnikes H, Tebbe JJ, Hildebrandt M, Arck P, Osmanoglou E, Rose M, Klapp B, Wiedenmann B, Heymann-Monnikes I (2001) Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity. Dig Dis 19:201–211PubMedCrossRef

Holtmann G, Kutscher SU, Haag S, Langkafel M, Heuft G, Neufang-Hueber J, Goebell H, Senf W, Talley NJ (2004) Clinical presentation and personality factors are predictors of the response to treatment in patients with functional dyspepsia; a randomized, double-blind placebo-controlled crossover study. Dig Dis Sci 49:672–679PubMedCrossRef

Feinle-Bisset C, Andrews JM (2003) Treatment of functional dyspepsia. Curr Treat Options Gastroenterol 6:289–297PubMedCrossRef

Fukudo S, Suzuki J (1987) Colonic motility, autonomic function, and gastrointestinal hormones under psychological stress on irritable bowel syndrome. Tohoku J Exp Med 151:373–385PubMedCrossRef

Barone FC, Deegan JF, Price WJ, Fowler PJ, Fondacaro JD, Ormsbee HS 3rd (1990) Cold-restraint stress increases rat fecal pellet output and colonic transit. Am J Physiol 258:G329–G337PubMed

Monnikes H, Schmidt BG, Tache Y (1993) Psychological stress-induced accelerated colonic transit in rats involves hypothalamic corticotropin-releasing factor. Gastroenterology 104:716–723PubMed

Gue M, Junien JL, Bueno L (1991) Conditioned emotional response in rats enhances colonic motility through the central release of corticotropin-releasing factor. Gastroenterology 100:964–970PubMed

Tache Y, Martinez V, Wang L, Million M (2004) CRF1 receptor signaling pathways are involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. Br J Pharmacol 141:1321–1330PubMedCrossRef

Martinez V, Tache Y (2001) Role of CRF receptor 1 in central CRF-induced stimulation of colonic propulsion in rats. Brain Res 893:29–35PubMedCrossRef

10.

Martinez V, Wang L, Rivier J, Grigoriadis D, Tache Y (2004) Central CRF, urocortins and stress increase colonic transit via CRF1 receptors while activation of CRF2 receptors delays gastric transit in mice. J Physiol 556:221–234PubMedCrossRef

11.

Nakade Y, Tsuchida D, Fukuda H, Iwa M, Pappas TN, Takahashi T (2005) Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats. Am J Physiol Regul Integr Comp Physiol 288:R427–R432PubMed

12.

Tache Y, Martinez V, Million M, Rivier J (1999) Corticotropin-releasing factor and the brain-gut motor response to stress. Can J Gastroenterol 13(Suppl A):18A–25APubMed

13.

Maillot C, Million M, Wei JY, Gauthier A, Tache Y (2000) Peripheral corticotropin-releasing factor and stress-stimulated colonic motor activity involve type 1 receptor in rats. Gastroenterology 119:1569–1579PubMedCrossRef

14.

Pothoulakis C, Castagliuolo I, Leeman SE (1998) Neuroimmune mechanisms of intestinal responses to stress. Role of corticotropin-releasing factor and neurotensin. Ann NY Acad Sci 840:635–648

15.

Martinez V, Rivier J, Wang L, Tache Y (1997) Central injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks CRF- and stress-related alterations of gastric and colonic motor function. J Pharmacol Exp Ther 280:754–760PubMed

16.

Williams CL, Peterson JM, Villar RG, Burks TF (1987) Corticotropin-releasing factor directly mediates colonic responses to stress. Am J Physiol 253:G582–G586PubMed

17.

Monnikes H, Schmidt BG, Raybould HE, Tache Y (1992) CRF in the paraventricular nucleus mediates gastric and colonic motor response to restraint stress. Am J Physiol 262:G137–G143PubMed

18.

Hurtak JJ (2002) An overview of acupuncture medicine. J Altern Complement Med 8:535–538PubMedCrossRef

19.

Campbell A (2002) The origins of acupuncture. Acupunct Med 20:141PubMedCrossRef

20.

National Institutes of Health (1997) Acupuncture. NIH Consens Statement 15:1–34

21.

Morey SS (1998) NIH issues consensus statement on acupuncture. Am Fam Phys 57:2545–2546

22.

Kunze M, Seidel HJ, Stube G (1990) [Comparative studies of the effectiveness of brief psychotherapy, acupuncture and papaverin therapy in patients with irritable bowel syndrome]. Z Gesamte Inn Med 45:625–627PubMed

23.

Chan J, Carr I, Mayberry JF (1997) The role of acupuncture in the treatment of irritable bowel syndrome: a pilot study. Hepatogastroenterology 44:1328–1330PubMed

24.

Fireman Z, Segal A, Kopelman Y, Sternberg A, Carasso R (2001) Acupuncture treatment for irritable bowel syndrome. A double-blind controlled study. Digestion 64:100–103

25.

Diehl DL (1999) Acupuncture for gastrointestinal and hepatobiliary disorders. J Altern Complement Med 5:27–45PubMedCrossRef

26.

Klauser AG, Rubach A, Bertsche O, Muller-Lissner SA (1993) Body acupuncture: effect on colonic function in chronic constipation. Z Gastroenterol 31:605–608PubMed

27.

Chen K, Zhou S, Zhao Y (1992) Auriculoacupuncture therapy—A traditional Chinese method of treatment. J Tradit Chin Med 12:308–310PubMed

28.

Broide E, Pintov S, Portnoy S, Barg J, Klinowski E, Scapa E (2001) Effectiveness of acupuncture for treatment of childhood constipation. Dig Dis Sci 46:1270–1275PubMedCrossRef

29.

Zhu Z, Li H, Chen L, Wang G, Kan C (2003) Acupuncture treatment of habitual constipation. J Tradit Chin Med 23:133PubMed

30.

Su Z (1992) Acupuncture treatment of infantile diarrhea: a report of 1050 cases. J Tradit Chin Med 12:120–121PubMed

31.

Anastasi JK, McMahon DJ (2003) Testing strategies to reduce diarrhea in persons with HIV using traditional Chinese medicine: acupuncture and moxibustion. J Assoc Nurses AIDS Care 14:28–40PubMedCrossRef

32.

Burgmann T, Rawsthorne P, Bernstein CN (2004) Predictors of alternative and complementary medicine use in inflammatory bowel disease: Do measures of conventional health care utilization relate to use? Am J Gastroenterol 99:889–893PubMedCrossRef

33.

Chen XH, Geller EB, Adler MW (1996) Electrical stimulation at traditional acupuncture sites in periphery produces brain opioid-receptor-mediated antinociception in rats. J Pharmacol Exp Ther 277:654–660PubMed

34.

Han JS (2003) Acupuncture: neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci 26:17–22PubMedCrossRef

35.

Han JS, Terenius L (1982) Neurochemical basis of acupuncture analgesia. Annu Rev Pharmacol Toxicol 22:193–220PubMedCrossRef

36.

Hahm ET, Lee JJ, Lee WK, Bae HS, Min BI, Cho YW (2004) Electroacupuncture enhancement of natural killer cell activity suppressed by anterior hypothalamic lesions in rats. Neuroimmunomodulation 11:268–272PubMedCrossRef

37.

Yu Y, Kasahara T, Sato T, Asano K, Yu G, Fang J, Guo S, Sahara M, Hisamitsu T (1998) Role of endogenous interferon-gamma on the enhancement of splenic NK cell activity by electroacupuncture stimulation in mice. J Neuroimmunol 90:176–186PubMedCrossRef

38.

Wu B (1995) [Effect of acupuncture on the regulation of cell-mediated immunity in the patients with malignant tumors]. Zhen Ci Yan Jiu 20:67–71PubMed

39.

Li L, Yin-Xiang C, Hong X, Peng L, Da-Nian Z (2001) Nitric oxide in vPAG mediates the depressor response to acupuncture in stress-induced hypertensive rats. Acupunct Electrother Res 26:165–170PubMed

40.

Yang CH, Lee BB, Jung HS, Shim I, Roh PU, Golden GT (2002) Effect of electroacupuncture on response to immobilization stress. Pharmacol Biochem Behav 72:847–855PubMedCrossRef

41.

Han SH, Yoon SH, Cho YW, Kim CJ, Min BI (1999) Inhibitory effects of electroacupuncture on stress responses evoked by tooth-pulp stimulation in rats. Physiol Behav 66:217–222PubMedCrossRef

42.

Liao YY, Seto K, Saito H, Fujita M, Kawakami M (1980) Effects of acupuncture on adrenocortical hormone production. (II) Effect of acupuncture on the response of adrenocortical hormone production to stress. Am J Chin Med 8:160–166

43.

Shen D, Liu B, Wi D, Zhang F, Chen Y (1994) [Effects of electroacupuncture on central and peripheral monoamine neurotransmitter in the course of protecting rat stress peptic ulcer]. Zhen Ci Yan Jiu 19:51–54PubMed

44.

Xiang L, Zhu F, Ma Y, Weng E, Tang G (1993) [Influences of acupuncture on gastroduodenal mucosal lesion and electrical changing induced by stress in rats]. Zhen Ci Yan Jiu 18:53–57PubMed

45.

Tatewaki M, Harris M, Uemura K, Ueno T, Hoshino E, Shiotani A, Pappas TN, Takahashi T (2003) Dual effects of acupuncture on gastric motility in conscious rats. Am J Physiol Regul Integr Comp Physiol 285:R862–R872PubMed

46.

Ishiguchi T, Amano T, Matsubayashi H, Tada H, Fujita M, Takahashi T (2001) Centrally administered neuropeptide Y delays gastric emptying via Y2 receptors in rats. Am J Physiol Regul Integr Comp Physiol 281:R1522–R1530PubMed

47.

Ishiguchi T, Tada H, Nakagawa K, Yamamura T, Takahashi T (2002) Hyperglycemia impairs antro-pyloric coordination and delays gastric emptying in conscious rats. Auton Neurosci 95:112–120PubMedCrossRef

48.

Fukumoto S, Tatewaki M, Yamada T, Fujimiya M, Mantyh C, Voss M, Eubanks S, Harris M, Pappas TN, Takahashi T (2003) Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. Am J Physiol Regul Integr Comp Physiol 284:R1269–R1276PubMed

49.

Martinez V, Wang L, Million M, Rivier J, Tache Y (2004) Urocortins and the regulation of gastrointestinal motor function and visceral pain. Peptides 25:1733–1744PubMedCrossRef

50.

Tsukada F, Nagura Y, Abe S, Sato N, Ohkubo Y (2003) Effect of restraint and footshock stress and norepinephrine treatment on gastric emptying in rats. Biol Pharm Bull 26:368–370PubMedCrossRef

51.

Mistiaen W, Blockx P, Van Hee R, Bortier H, Harrisson F (2002) The effect of stress on gastric emptying rate measured with a radionuclide tracer. Hepatogastroenterology 49:1457–1460PubMed

52.

Lenz HJ, Burlage M, Raedler A, Greten H (1988) Central nervous system effects of corticotropin-releasing factor on gastrointestinal transit in the rat. Gastroenterology 94:598–602PubMed

53.

Enck P, Merlin V, Erckenbrecht JF, Wienbeck M (1989) Stress effects on gastrointestinal transit in the rat. Gut 30:455–459PubMedCrossRef

54.

Muraoka M, Mine K, Kubo C (1998) A study of intestinal dysfunction induced by restraint stress in rats. Scand J Gastroenterol 33:806–810PubMedCrossRef

55.

Kalin NH, Takahashi LK, Chen FL (1994) Restraint stress increases corticotropin-releasing hormone mRNA content in the amygdala and paraventricular nucleus. Brain Res 656:182–186PubMedCrossRef

56.

Liu JH, Yan J, Yi SX, Chang XR, Lin YP, Hu JM (2004) Effects of electroacupuncture on gastric myoelectric activity and substance P in the dorsal vagal complex of rats. Neurosci Lett 356:99–102PubMedCrossRef

57.

Sato A, Sato Y, Suzuki A, Uchida S (1993) Neural mechanisms of the reflex inhibition and excitation of gastric motility elicited by acupuncture-like stimulation in anesthetized rats. Neurosci Res 18:53–62PubMedCrossRef

58.

Chang CS, Chou JW, Wu CY, Chang YH, Ko CW, Chen GH (2002) Atropine-induced gastric dysrhythmia is not normalized by electroacupuncture. Dig Dis Sci 47:2466–2472PubMedCrossRef

59.

Ouyang H, Yin J, Wang Z, Pasricha PJ, Chen JD (2002) Electroacupuncture accelerates gastric emptying in association with changes in vagal activity. Am J Physiol Gastrointest Liver Physiol 282:G390–G396PubMed

60.

Monnikes H, Raybould HE, Schmidt B, Tache Y (1993) CRF in the paraventricular nucleus of the hypothalamus stimulates colonic motor activity in fasted rats. Peptides 14:743–747PubMedCrossRef

61.

Monnikes H, Schmidt BG, Tebbe J, Bauer C, Tache Y (1994) Microinfusion of corticotropin releasing factor into the locus coeruleus/subcoeruleus nuclei stimulates colonic motor function in rats. Brain Res 644:101–108PubMedCrossRef

62.

Million M, Wang L, Martinez V, Tache Y (2000) Differential Fos expression in the paraventricular nucleus of the hypothalamus, sacral parasympathetic nucleus and colonic motor response to water avoidance stress in Fischer and Lewis rats. Brain Res 877:345–353PubMedCrossRef

63.

Valentino RJ, Page ME, Luppi PH, Zhu Y, Van Bockstaele E, Aston-Jones G (1994) Evidence for widespread afferents to Barrington’s nucleus, a brainstem region rich in corticotropin-releasing hormone neurons. Neuroscience 62:125–143PubMedCrossRef

64.

Lewis TD (1999) Morphine and gastroduodenal motility. Dig Dis Sci 44:2178–2186PubMedCrossRef

65.

Qian LW, Lin YP (1993) [Effect of electroacupuncture at zusanli (ST36) point in regulating the pylorus peristaltic function]. Zhongguo Zhong Xi Yi Jie He Za Zhi 13(324):336–339PubMed

66.

Boscan P, Pickering AE, Paton JF (2002) The nucleus of the solitary tract: an integrating station for nociceptive and cardiorespiratory afferents. Exp Physiol 87:259–266PubMedCrossRef

67.

Kaptchuk TJ (2002) Acupuncture: theory, efficacy, and practice. Ann Intern Med 136:374–383PubMed

68.

Travagli RA, Gillis RA, Vicini S (1992) Effects of thyrotropin-releasing hormone on neurons in rat dorsal motor nucleus of the vagus, in vitro. Am J Physiol 263:G508–G517PubMed

69.

Washabau RJ, Fudge M, Price WJ, Barone FC (1995) GABA receptors in the dorsal motor nucleus of the vagus influence feline lower esophageal sphincter and gastric function. Brain Res Bull 38:587–594PubMedCrossRef

70.

Travagli RA, Gillis RA, Rossiter CD, Vicini S (1991) Glutamate and GABA-mediated synaptic currents in neurons of the rat dorsal motor nucleus of the vagus. Am J Physiol 260:G531–G536PubMed

71.

Sivarao DV, Krowicki ZK, Abrahams TP, Hornby PJ (1999) Vagally-regulated gastric motor activity: evidence for kainate and NMDA receptor mediation. Eur J Pharmacol 368:173–182PubMedCrossRef

72.

Sivarao DV, Krowicki ZK, Hornby PJ (1998) Role of GABAA receptors in rat hindbrain nuclei controlling gastric motor function. Neurogastroenterol Motil 10:305–313PubMedCrossRef

73.

Valentino RJ, Miselis RR, Pavcovich LA (1999) Pontine regulation of pelvic viscera: pharmacological target for pelvic visceral dysfunctions. Trends Pharmacol Sci 20:253–260PubMedCrossRef

74.

Gamboa-Esteves FO, Lima D, Batten TF (2001) Neurochemistry of superficial spinal neurones projecting to nucleus of the solitary tract that express c-fos on chemical somatic and visceral nociceptive input in the rat. Metab Brain Dis 16:151–164PubMedCrossRef

75.

Lee CH, Jung HS, Lee TY, Lee SR, Yuk SW, Lee KG, Lee BH (2001) Studies of the central neural pathways to the stomach and Zusanli (ST36). Am J Chin Med 29:211–220PubMedCrossRef

76.

Liu JH, Li J, Yan J, Chang XR, Cui RF, He JF, Hu JM (2004) Expression of c-fos in the nucleus of the solitary tract following electroacupuncture at facial acupoints and gastric distension in rats. Neurosci Lett 366:215–219PubMedCrossRef

77.

Toney GM, Mifflin SW (2000) Sensory modalities conveyed in the hindlimb somatic afferent input to nucleus tractus solitarius. J Appl Physiol 88:2062–2073PubMed

Titel: Electroacupuncture Elicits Dual Effects: Stimulation of Delayed Gastric Emptying and Inhibition of Accelerated Colonic Transit Induced by Restraint Stress in Rats
verfasst von: Masahiro Iwa
Yukiomi Nakade
Theodore N. Pappas
Toku Takahashi
Publikationsdatum: 01.08.2006
Verlag: Springer US
Erschienen in: Digestive Diseases and Sciences / Ausgabe 8/2006
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-006-9083-7

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 8/2006

Distribution of HCV Genotypes in Patients with End-Stage Renal Disease According to Type of Dialysis Treatment

Expression of Transforming Growth Factor-α and -β in Hepatic Lobes After Hemihepatic Portal Vein Embolization

Epidermal Growth Factor Enhances Intracellular pH Regulation via Calcium Signaling in Acid-Exposed Primary Cultured Rabbit Gastric Epithelial Cells

No Evidence for an Involvement of the P38 and JNK Mitogen-Activated Protein in Inflammatory Bowel Diseases

A Population-Based Study on Bowel Habits in a Korean Community: Prevalence of Functional Constipation and Self-Reported Constipation