Background
Classification and biogenesis of circRNAs
Spliceosome-dependent lariat-driven circularization
Intron-pairing circulation
RNA-binding proteins (RBP)-induced circulation
Mechanism and function of circRNAs in cancer
As competing endogenous RNAs or miRNA sponges
Protein translation
CircRNA-protein interaction
Other functional mechanism
CircRNAs in cancer
Cancer type | CircRNA | Funtion | Expression in tumors | References |
---|---|---|---|---|
Lung adenocarcinoma | hsa_circ_0012673 | promotes LAC cell proliferation and tumor growth by decoying miR-22 | Up | [42] |
hsa_circ_0013958 | promotes cell proliferation, migration and invasion by sponging miR-134 | Up | [57] | |
circPRKC1 | positively correlated with tumor size and TNM stage, promotes cell proliferation and migration by regulating miR-545/589 | Up | [6] | |
circRNA_102231 | associated with the advanced TNM stage, lymph node metastasis and poor overall survival, promotes cell proliferation and invasion ability | Up | [58] | |
has_circ_0007385 | promotes the proliferation activity, colony-forming ability, migration and invasion of NSCLC cells in vitro and the tumor growth in vivo by decoying miR-181 | Up | [59] | |
circ0006916 | inhibits cell proliferation by regulating cell cycle progression | Down | [60] | |
f-circEA | promotes cell migration and invasion | Up | [7] | |
circFARSA | promotes cell migration and invasion by sponging miR-330-5p and miR-326 | Up | [63] | |
hsa_circRNA_103809 | promotes cell proliferation and invasion in vitro and tumor growth in vivo by sponging miR-4302 | Up | [61] | |
circFADS2 | correlated with advanced TNM stage, lymph node metastasis, poor differentiation and shorter overall survival of NSCLC patients. promotes cell proliferation and invasion ability | Up | [62] | |
Colorectal cancer | circHIPK3 | promotes cell proliferation, and colony-forming ability, migration and invasion by decoying miR-7 invasion by decoying miR-7 | Up | [8] |
circCCDC66 | promotes cancer cell proliferation, migration and metastasis in vitro and in vivo by sponging miRNA-33b and miR-93 | Up | [9] | |
ciRS-7 | positively correlated with advanced tumor stage, tumor depth and metastasis by downregulating miR-7 | UP | [64] | |
circBANP | related with cell proliferation and colony formation ability | Up | [65] | |
hsa_circ_0014717 | correlated with TNM stage, distal metastasis, and prognosis of CRC patients, antagonizes cell proliferation and colony-forming ability, as well as induces cell cycle arrest at G0/G1 phase | Down | [66] | |
Gastric cancer | has_cric_0000096 | inhibits gastric cancer proliferation and migration by suppressing cyclin D1, CDK6, MMP-2 and MMP-9 | Down | [68] |
circPVT1 | promotes cell proliferation by sponging miR-125 | Up | [11] | |
circLARP4 | Impairs GC cell proliferation and invasion, associated with tumor size, lymphatic metastasis and the therapeutic outcomes of GC patients by regulating miR-424 | Down | [10] | |
Pancreatic cancer | hsa_circ_0000977 | associated with poor prognosis in PDAC patients, promotes cell proliferation and colony formation ability by sponging hsa-miR-874-3p | Up | [43] |
circ-LDLRAD3 | associated with venous invasion, lymphatic invasion and metastasis | Up | [70] | |
circPDE8A | correlated with lymphatic invasion, T factor and TNM stage, promotes migration or invasion, cell proliferation and EMT | Up | [71] | |
Hepatocellular carcinoma | circMTO1 | correlates with the poor survival of patients, inhibits cell proliferation and invasion by decoying miR-9 | Down | [13] |
circARSP91 | AR suppresses circARSP91expression by upregulating the expression of ADAR1 | Down | [14] | |
cSMARCA5 | correlated with advanced tumor stage, tumor size and the presence of microvascular invasion through sponging miR-17-3p an miR-181b-5p | Down | [15] | |
circ_0067934 | promotes cell proliferation and metastasis in vitro and in vivo by regulating miR-1324 | Up | [72] | |
circRNA_100,338 | correlated with decreased cumulative survival rate, increased vascular invasion and lung metastasis in HCC patients by suppressing miR-141-3p | Up | [73] | |
circHIPK3 | promotes the proliferation and migration of HCC cells, as well as xenograft tumor growth in vivo by downregulating miR-124 | Up | [12] | |
circC3P1 | represses the migration and invasion of HCC cells in vitro, and inhibits HCC cells proliferation and lymphatic metastasis in vivo by sponging miR-4641 | Down | [74] | |
Breast cancer | circGFRA1 | correlated with tumor size, TNM staging, lymph node metastasis and histological grade, promotes cell proliferation and the colony-forming ability by decoying miR-34a | Up | [16] |
circAmotl1 | increases invasive capacity, reduces number of apoptosis cells, and augmentes tumor-forming capacity by promoting c-myc nucleus-translocation | Up | [17] | |
circRNA-000911 | suppresses the invasive capacity and proliferation, reduces colony formation ability and elevates the proportion of apoptotic cells by sponging miR-449a | Down | [75] | |
cricABCB10 | promotes cell proliferation and colony formation capacity by downregulating miR-1271 | Up | [76] | |
hsa_circ_0011946 | correlated with RFC3 expression, promotes migration and invasion of MCF-7 cell | Up | [77] | |
Bladder cancer | circ-ITCH | suppresses cell proliferation, migration and invasion in vitro, as well as tumorigenesis in vivo, through sponging miR-17 and miR-224 | Down | [44] |
circRNA-MYLK | increases the tumorigenicity of BC cells, distinct metastatic lesions in mice lungs and tumor microvessels by decoying miR-29a/ | Up | [79] | |
circHIPK3 | suppresses the aggressiveness and metastasis of bladder cancer cells in vitro and in vivo by targeting miR-558 | Down | [80] | |
Cdr1as | inhibits the migration and invasion capabilities, as well as induces cell cycle arrest | Down | [81] | |
Glioblastoma | circ-FBXW7 | associated with glioblastoma patient overall survival, inhibits proliferation and cell cycle acceleration by encoding FBXW7-185aa | Down | [51] |
circSHPRH | encodes SHPRH-146aa which can protect SHPRH and reduce proliferation and the malignant phenotype | Down | [52] | |
circ-SHKBP1 | promotes the viability, migration and tube formation of glioma-exposed endothelial cells by sponging miR-544a or miR-379 | Up | [45] | |
cric-TTBK2 | promotes cell proliferation, migration and invasion, but inhibits the apoptosis of glioma cells by regulating miR-217 | Up | [82] | |
Other cancers | ||||
Oral squamous cell carcinomas | circRNA_100290 | promotes cell proliferation in vitro and the growth of tumors in vivo by decoying miR-29b | Up | [46] |
circDOCK1 | inhibits cell apoptosis by sponging miR-196a-5p | Up | [83] | |
Osteosarcoma | cricUBAP2 | correlated with tumor stages, promotes cell proliferation in vitro and cell growth in vivo by downregulating miR-143 | Up | [47] |
circ-NT5C2 | correlated with tumor volume and weight in a mice model, promotes cell proliferation and invasion in vitro by decoying miR-448 | Up | [84] | |
circRNA_0009910 | promotes cell proliferation and inhibits apoptosis by sponging miR-449a/IL6R | Up | [85] | |
has_circ_0001564 | promotes cell viability and the colony formation vitality by decoying miR-29c-3p | Up | [87] | |
circNASP | promotes the proliferation and invasion of OS cells by sponging miR-1253 | Up | [86] | |
Hematological tumors | f-circM9, f-circPR | contributes to cellular transformation, and promotes cell viability and resistance upon therapy | Up | [54] |
Lung adenocarcinoma
Colorectal cancer
Gastric cancer
Pancreatic cancer
Hepatocellular carcinoma
Breast cancer
Bladder cancer (BCa)
Glioblastoma
Other cancers
Circular RNAs as a biomarker in cancer
circRNA | Cancer type | Expression in plasma | Clinical correlation | ROC curve | References | ||
---|---|---|---|---|---|---|---|
AUC | sensitivity | Specifity | |||||
Hsa_circ_0013958 | LAC | up | TNM stage, lymphatic metastasis | 0.815 | 0.755 | 0.796 | [57] |
F-circEA | NSCLC | up | – | – | – | – | [7] |
Hsa_circ_000745 | GC | down | tumor differentiation | 0.775 | 0.800 | 0.633 | [93] |
Hsa_circ_0001017 /hsa_circ_0061276 | GC | Down | distal metastasis | 0.966 | 0.955 | 0.957 | [94] |
Hsa_circ_0000520 | GC | Down | TNM stage, CEA expression | 0.8967 | 0.8235 | 0.8444 | [95] |
Hsa_circ_2059 | GC | Down | distal metastasis, TNM stage, gender and age | 0.73 | – | – | [97] |
Circ-LDLRAD3 | Pancreatic cancer | Up | venous invasion, lymphatic invasion | 0.87 | 0.8033 | 0.9355 | [70] |
CircPVT1 | OS | Up | advanced Enneking stage, chemoresistance, lung metastasis | 0.871 | – | – | [98] |
Circ-KLDHC10 | CRC | Up | – | – | – | – | [99] |
Circ-PDE8A | PDAC | Up | duodenal invasion, vascular invasion, T factor or TNM stage | – | – | – | [71] |