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01.10.2009 | Leading Article

Emerging Treatments in Cystic Fibrosis

verfasst von: Dr Andrew M. Jones, Jennifer M. Helm

Erschienen in: Drugs | Ausgabe 14/2009

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Abstract

There are a number of potential drugs for the treatment of cystic fibrosis (CF) currently undergoing clinical studies. A number of antibacterials formulated for delivery by inhalation are at various stages of study; these include dry-powder inhaler versions of colistin, tobramycin and ciprofloxacin, and formulations of azteonam, amikacin, levofloxacin, ciprofloxacin and fosfomycin/tobramycin for nebulization. Clinical trials of anti-inflammatory agents, including glutathione, phosphodiesterase-5 inhibitors such as sildenafil, oral acetylcysteine, simvastatin, methotrexate, docosahexaenoic acid, hydroxychloroquine, pioglitazone and α1-antitrypsin, are ongoing. Ion channel modulating agents, such as lancovutide (Moli1901, duramycin) and denufosol, which activate alternate (non-CF transmembrane regulator [CFTR]) chloride channels, and GS 9411, a sodium channel antagonist, are now at the stages of clinical study and if successful, will offer a new category of therapeutic agent for the treatment of CF. Correction of the underlying gene effect, either by agents that help to correct the dysfunctional CFTR, such as ataluren, VX-770 and VX-809, or by gene transfer (gene therapy), is a particularly exciting prospect as a new therapy for CF and clinical studies are ongoing. This article reviews the exciting potential drug treatments for CF currently being evaluated in clinical studies, and also highlights some of the challenges faced by research and clinical teams in assessing the efficacy of potential new therapies for CF.

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Titel: Emerging Treatments in Cystic Fibrosis
verfasst von: Dr Andrew M. Jones
Jennifer M. Helm
Publikationsdatum: 01.10.2009
Verlag: Springer International Publishing
Erschienen in: Drugs / Ausgabe 14/2009
Print ISSN: 0012-6667
Elektronische ISSN: 1179-1950
DOI: https://doi.org/10.2165/11318500-000000000-00000

Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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Live-Webinar "Urologie und Sexualmedizin in der Praxis"

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