Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende
Erweiterte Suche
Anmelden
nach oben
Journal of Assisted Reproduction and Genetics
Erschienen in: Journal of Assisted Reproduction and Genetics 3/2012

01.03.2012 | ASSISTED REPRODUCTION TECHNOLOGIES

Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS

verfasst von: Juan C. Castillo, Juan Garcia-Velasco, Peter Humaidan

Erschienen in: Journal of Assisted Reproduction and Genetics | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study aimed to explore the incidence of empty follicle syndrome (EFS) in oocyte donors who had final oocyte maturation triggered with GnRHa and to compare the incidence of EFS in this group of patients with IVF patients who had final oocyte maturation with hCG.

Methods

Data including 2034 oocyte donation cycles and 1433 IVF cycles performed between years 2009 and 2010 was retrospectively analyzed to identify cases of EFS in each group.

Results

The incidence of EFS in the two groups did not differ significantly, 3.5% versus 3.1%, (n.s.).

Conclusions

This large retrospective analysis indicates that the incidence of EFS is not increased after GnRHa triggering as compared to hCG triggering.
Literatur
1.
Humaidan P, Kol S, Papanikolaou E, The Copenhagen GnRH Agonist Triggering Workshop Group. GnRH agonist for triggering of final oocyte maturation: time for a change of practice? Hum Reprod Update. 2011;17:510–4.PubMedCrossRef
2.
Honnma H, Hashiba Y, Asada Y, Endo T. Failure of triggering oocyte maturation with a GnRH agonist in polycystic ovary syndrome: two case reports. Eur J Obstet Gynecol Reprod Biol In Press. doi:10.​1016/​j.​ejogrb.​2011.​03.​002.
3.
Griesinger G, Schultz L, Bauer T, Broessner A, Frambach T, Kissler S. Ovarian hyperstimulation syndrome prevention by gonadotropin-releasing hormone agonist triggering of final oocyte maturation in a gonadotropin-releasing hormone antagonist protocol in combination with a “freeze-all” strategy: a prospective multicentric study. Fertil Steril. 2011;95:2029–33.PubMedCrossRef
4.
Ben-Shlomo I, Schiff E, Levran D, Ben-Rafael Z. Failure of oocyte retrieval during invitro fertilization: a sporadic event rather than a syndrome. Fertil Steril. 1991;55:324–7.PubMed
5.
Awonuga A, Govindbhai J, Zierke S, Schnauffer K. Continuing the debate on empty follicle syndrome: can it be associated with normal bioavailability of b-human chorionic gonadotrophin on the day of oocyte recovery? Hum Reprod. 1998;13:1281–4.PubMedCrossRef
6.
Zreik TG, Garcia-Velasco JA, Vergara TM, Arici A, Olive D, Jones EE. Empty follicle syndrome: evidence for recurrence. Hum Reprod. 2000;15:999–1002.PubMedCrossRef
7.
Zegers-Hochschild F, Fernandez E, Machenna A, Fabres C, Alteiri E, Lopez T. The empty follicle syndrome: a pharmaceutical industry syndrome. Hum Reprod. 1995;10:2262–5.PubMed
8.
Ndukwe G, Thornton S, Fishel S, Dowell K, Aloum M, Green S. ‘Curing’ empty follicle syndrome. Hum Reprod. 1997;12:21–3.PubMedCrossRef
9.
Ubaldi F, Nagy Z, Janssenwillen C, Smitz J, Van Steirteghem A, Devroey P. Ovulation by repeated human chorionic gonadotrophin in ‘empty follicle syndrome’ yields a twin clinical pregnancy. Hum Reprod. 1997;12:454–6.PubMedCrossRef
10.
Quintans CJ, Donaldson MJ, Blanco LA, Pasqualini RS. Empty follicle syndrome due to human errors: its occurrence in an in-vitro fertilization programme. Hum Reprod. 1998;13:2703–5.PubMed
11.
Gonen Y, Balakier H, Powell W, Casper RF. Use of gonadotropin-releasing hormone agonist to trigger follicular maturation for in vitro fertilization. J Clin Endocrinol Metab. 1990;71:918–22.PubMedCrossRef
12.
Itskovitz J, Boldes R, Levron J, Erlik Y, Kahana L, Brandes JM. Induction of preovulatory luteinizing hormone surge and prevention of ovarian hyperstimulation syndrome by gonadotropin-releasing hormone agonist. Fertil Steril. 1991;56:213–20.PubMed
13.
Hoff JD, Quigley ME, Yen SS. Hormonal dynamics at midcycle: a reevaluation. J Clin Endocrinol Metab. 1983;57:792–6.PubMedCrossRef
14.
Damewood MD, Shen W, Zacur HA, Schlaff WD, Rock JA, Wallach EE. Disappearance of exogenously administered human chorionic gonadotropin. Fertil Steril. 1989;52:398–400.PubMed
15.
Weissman A, Lurie S, Zalel Y, Goldchmit R, Shoham Z. Human chorionic gonadotropin: pharmacokinetics of subcutaneous administration. Gynecol Endocrinol. 1996;10:273–6.PubMedCrossRef
16.
Stevenson TL, Lashen H. Empty follicle syndrome: the reality of a controversial syndrome, a systematic review. Fertil Steril. 2008;90:691–8.PubMedCrossRef
17.
Parneix I, Emperaire JC, Ruffie A, Parneix P. Comparison of different protocols of ovulation induction, by GnRH agonists and chorionic gonadotropin. Gynecol Obstet Fertil. 2001;29:100–5.PubMedCrossRef
18.
Díaz I, Guillén A, Pacheco A, Requena A, Garcia-Velasco JA. Endocrine modifications associated with final oocyte maturation with gonadotropin-releasing hormone agonists vs. human chorionic gonadotropin in women undergoing intrauterine insemination. J Reprod Med. 2008;53:33–9.PubMed
19.
Fauser BC, de Jong D, Olivennes F, Wramsby H, Tay C, Itskovitz-Eldor J, van Hooren HG. Endocrine profiles after triggering of final oocyte maturation with GnRH agonist after cotreatment with the GnRH antagonist ganirelix during ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2002;87:709–15.PubMedCrossRef
20.
Engmann L, Siano L, Schmidt D, Nulsen J, Maier D, Benadiva C. GnRH agonist to induce oocyte maturation during IVF in patients at high risk of OHSS. Reprod Biomed Online. 2006;13:639–44.PubMedCrossRef
21.
Bodri D, Guillén JJ, Trullenque M, Schwenn K, Esteve C, Coll O. Early ovarian hyperstimulation syndrome is completely prevented by gonadotropin releasing-hormone agonist triggering in high-risk oocyte donor cycles: a prospective, luteal-phase follow-up study. Fertil Steril. 2010;93:2418–20.PubMedCrossRef
22.
Yariz KO, Walsh T, Uzak A, Spiliopoulos M, Duman D, Onalan G, King MC, Tekin M. Inherited mutation of the luteinizing hormone/choriogonadotropin receptor (LHCGR) in empty follicle syndrome. Fertil Steril. 2011 (in press).
23.
Khalaf Y, Braude P. ‘Curing’ empty follicle syndrome. Hum Reprod. 1997;12:1601.PubMed
24.
Tsuiki A, Rose BI, Hung TT. Steroid profiles of follicular fluids from a patient with the empty follicle syndrome. Fertil Steril. 1988;49:104–7.PubMed
25.
Beranova M, Oliveira LM, Bédécarrats GY, Schipani E, Vallejo M, Ammini AC, Quintos JB, Hall JE, Martin KA, Hayes FJ, Pitteloud N, Kaiser UB, Crowley Jr WF, Seminara SB. Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab. 2001;86:1580–8.PubMedCrossRef
26.
Perez Mayorga M, Gromoll J, Behre HM, Gassner C, Nieschlag E, Simoni M. Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype. J Clin Endocrinol Metab. 2000;85:3365–9.PubMedCrossRef
27.
Piersma D, Verhoef-Post M, Berns EM, Themmen AP. LH receptor gene mutations and polymorphisms: an overview. Mol Cell Endocrinol. 2007;260–262:282–6.PubMedCrossRef
28.
Alviggi C, Clarizia R, Pettersson K, Mollo A, Humaidan P, Strina I, Coppola M, Ranieri A, D’Uva M, De Placido G. Suboptimal response to GnRHa long protocol is associated with a common LH polymorphism. Reprod Biomed Online. 2009;18:9–14.PubMedCrossRef
29.
Pettersson KS, Söderholm JR. Individual differences in lutropin immunoreactivity revealed by monoclonal antibodies. Clin Chem. 1991;37:333–40.PubMed
Metadaten
Titel
Empty follicle syndrome after GnRHa triggering versus hCG triggering in COS
verfasst von
Juan C. Castillo
Juan Garcia-Velasco
Peter Humaidan
Publikationsdatum
01.03.2012
Verlag
Springer US
Erschienen in
Journal of Assisted Reproduction and Genetics / Ausgabe 3/2012
Print ISSN: 1058-0468
Elektronische ISSN: 1573-7330
DOI
https://doi.org/10.1007/s10815-011-9704-8

Weitere Artikel der Ausgabe 3/2012

Journal of Assisted Reproduction and Genetics 3/2012 Zur Ausgabe

ASSISTED REPRODUCTION TECHNOLOGIES

A successful birth of healthy monozygotic dichorionic diamniotic (DD) twins of the same gender following a single vitrified-warmed blastocyst transfer

ASSISTED REPRODUCTION TECHNOLOGIES

Pregnancy outcomes in oocyte donation recipients: vaginal gel versus intramuscular injection progesterone replacement

Fertility Preservation

Live birth from oocytes cryopreserved with slow-freezing protocol and thawed after 6 years of storage

Fertility Preservation

Oocyte cryopreservation in a patient with sickle cell disease prior to hematopoietic stem cell transplantation: first report

ASSISTED REPRODUCTION TECHNOLOGIES

Comparison of cabergoline and intravenous albumin in the prevention of ovarian hyperstimulation syndrome: a randomized clinical trial

ASSISTED REPRODUCTION TECHNOLOGIES

Elevated day 3 FSH/LH ratio: a marker to predict IVF outcome in young and older women

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Hirsutismus bei PCOS: Laser- und Lichttherapien helfen

26.04.2024 Hirsutismus Nachrichten

Laser- und Lichtbehandlungen können bei Frauen mit polyzystischem Ovarialsyndrom (PCOS) den übermäßigen Haarwuchs verringern und das Wohlbefinden verbessern – bei alleiniger Anwendung oder in Kombination mit Medikamenten.

ICI-Therapie in der Schwangerschaft wird gut toleriert

23.04.2024 Medikamente in Schwangerschaft und Stillzeit Nachrichten

Müssen sich Schwangere einer Krebstherapie unterziehen, rufen Immuncheckpointinhibitoren offenbar nicht mehr unerwünschte Wirkungen hervor als andere Mittel gegen Krebs.

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

23.04.2024 Depression antepartal oder postpartal Nachrichten

Bislang gibt es kein Medikament zur Prävention von Wochenbettdepressionen. Das Injektionsanästhetikum Esketamin könnte womöglich diese Lücke füllen.

Bei RSV-Impfung vor 60. Lebensjahr über Off-Label-Gebrauch aufklären!

22.04.2024 DGIM 2024 Kongressbericht

Durch die Häufung nach der COVID-19-Pandemie sind Infektionen mit dem Respiratorischen Synzytial-Virus (RSV) in den Fokus gerückt. Fachgesellschaften empfehlen eine Impfung inzwischen nicht nur für Säuglinge und Kleinkinder.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise