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Heart Failure Reviews

Erschienen in:

19.02.2020 | Myocardial Infarction

Environmentally responsive hydrogels for repair of cardiovascular tissue

verfasst von: Shuaimeng Guan, Jiankang Li, Kun Zhang, Jingan Li

Erschienen in: Heart Failure Reviews | Ausgabe 5/2021

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Abstract

Cardiovascular diseases (CVDs) pose a serious threat to human health, which are characterized by high disability and mortality rate globally such as myocardial infarction (MI), atherosclerosis, and heart failure. Although stem cells transplantation and growth factors therapy are promising, their low survival rate and loss at the site of injury are major obstacles to this therapy. Recently, the development of hydrogel scaffold materials provides a new way to solve this problem, which have shown the potential to treat CVD. Among these scaffold materials, environmentally responsive hydrogels have great prospects in repairing the microenvironment of cardiovascular tissues and vascular regeneration. They provide a new method for the treatment of cardiovascular tissue repair and space-time control for the release of various therapeutic drugs, including small-molecule drugs, growth factors, and stem cells. Herein, this article reviews the occurrence and current treatment of CVD, as well as the repair of cardiovascular injury by several environmental responsive hydrogels systems currently used, mainly focusing on the delivery of growth factors or the application of cell therapy to revascularization. In addition, we will also discuss the enormous potential and personal perspectives of environmentally responsive hydrogels in cardiovascular repair.

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Titel: Environmentally responsive hydrogels for repair of cardiovascular tissue
verfasst von: Shuaimeng Guan
Jiankang Li
Kun Zhang
Jingan Li
Publikationsdatum: 19.02.2020
Verlag: Springer US
Schlagwörter: Myocardial Infarction
Growth Factors
Erschienen in: Heart Failure Reviews / Ausgabe 5/2021
Print ISSN: 1382-4147
Elektronische ISSN: 1573-7322
DOI: https://doi.org/10.1007/s10741-020-09934-y

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