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Angiogenesis

Erschienen in:

28.06.2017 | Review Paper

Tumor angiogenesis and vascular normalization: alternative therapeutic targets

verfasst von: Claire Viallard, Bruno Larrivée

Erschienen in: Angiogenesis | Ausgabe 4/2017

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Abstract

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal vascular network characterized by disorganized, immature and permeable blood vessels, resulting in poorly perfused tumors. The hypoxic microenvironment created by impaired tumor perfusion can promote the selection of more invasive and aggressive tumor cells and can also impede the tumor-killing action of immune cells. Furthermore, abnormal tumor perfusion also reduces the diffusion of chemotherapeutic drugs and radiotherapy efficiency. To fight against this defective phenotype, the normalization of the tumor vasculature has emerged as a new therapeutic strategy. Vascular normalization, by restoring proper tumor perfusion and oxygenation, could limit tumor cell invasiveness and improve the effectiveness of anticancer treatments. In this review, we investigate the mechanisms involved in tumor angiogenesis and describe strategies used to achieve vascular normalization.

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Titel: Tumor angiogenesis and vascular normalization: alternative therapeutic targets
verfasst von: Claire Viallard
Bruno Larrivée
Publikationsdatum: 28.06.2017
Verlag: Springer Netherlands
Erschienen in: Angiogenesis / Ausgabe 4/2017
Print ISSN: 0969-6970
Elektronische ISSN: 1573-7209
DOI: https://doi.org/10.1007/s10456-017-9562-9

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