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Erschienen in: Gastro-News 3/2023

16.06.2023 | Eosinophile Ösophagitis | Zertifizierte Fortbildung

Immunvermittelte Inflammation der Speiseröhre

Pathophysiologie, Diagnostik und Therapie der eosinophilen Ösophagitis

verfasst von: Prof. Dr. med. habil. Ahmed Madisch, Prof. Dr. med. Martin Storr

Erschienen in: Gastro-News | Ausgabe 3/2023

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Unter den eosinophilen Erkrankungen des Gastrointestinaltraktes ist die eosinophile Ösophagitis die häufigste und am besten bekannte Erkrankung. In den letzten zehn Jahren hat sich das Wissen zu Pathophysiologie und Diagnostik etabliert und die Behandlung, auch durch neue, krankheitsspezifische Therapien stark gewandelt.
Literatur
1.
Zurück zum Zitat MM Walker, M Potter, NJ Talley. Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus. Lancet Gastroenterol Hepatol 2018;3:271-80 MM Walker, M Potter, NJ Talley. Eosinophilic gastroenteritis and other eosinophilic gut diseases distal to the oesophagus. Lancet Gastroenterol Hepatol 2018;3:271-80
2.
Zurück zum Zitat Dellon ES, Hirano I. Epidemiology and Natural History of Eosinophilic Esophagitis. Gastroenterology. 2018;154:319-32.e3. Dellon ES, Hirano I. Epidemiology and Natural History of Eosinophilic Esophagitis. Gastroenterology. 2018;154:319-32.e3.
3.
Zurück zum Zitat Navarro P, Arias Á, Arias-González L et al. Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther. 2019;49:1116-25 Navarro P, Arias Á, Arias-González L et al. Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther. 2019;49:1116-25
4.
Zurück zum Zitat Madisch A, Koop H, Miehlke et al. S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). Z Gastroenterol 2023 in prep. Madisch A, Koop H, Miehlke et al. S2k-Leitlinie Gastroösophageale Refluxkrankheit und eosinophile Ösophagitis der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS). Z Gastroenterol 2023 in prep.
5.
Zurück zum Zitat Hirano I, Furuta GT. Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis. Gastroenterology. 2020;158(4):84051 Hirano I, Furuta GT. Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis. Gastroenterology. 2020;158(4):84051
6.
Zurück zum Zitat Miehlke S. Clinical features of Eosinophilic esophagitis in children and adults. Best Pract Res Clin Gastroenterol. 2015;29:73948 Miehlke S. Clinical features of Eosinophilic esophagitis in children and adults. Best Pract Res Clin Gastroenterol. 2015;29:73948
7.
Zurück zum Zitat Alexander R, Alexander JA, Ravi K et al. Measurement of Observed Eating Behaviors in Patients With Active and Inactive Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2019;17:237173 Alexander R, Alexander JA, Ravi K et al. Measurement of Observed Eating Behaviors in Patients With Active and Inactive Eosinophilic Esophagitis. Clin Gastroenterol Hepatol. 2019;17:237173
8.
Zurück zum Zitat Miehlke S. Eosinophile Ösophagitis Gastroenterologe. 2018;13:6372 Miehlke S. Eosinophile Ösophagitis Gastroenterologe. 2018;13:6372
9.
Zurück zum Zitat Hirano I, Moy N, Heckman MG et al. Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system. Gut. 2013;62:48995 Hirano I, Moy N, Heckman MG et al. Endoscopic assessment of the oesophageal features of eosinophilic oesophagitis: validation of a novel classification and grading system. Gut. 2013;62:48995
10.
Zurück zum Zitat Krarup AL, Drewes AM, Ejstrud P et al. Implementation of a biopsy protocol to improve detection of esophageal eosinophilia: a Danish registry-based study. Endoscopy. 2021;53:1524 Krarup AL, Drewes AM, Ejstrud P et al. Implementation of a biopsy protocol to improve detection of esophageal eosinophilia: a Danish registry-based study. Endoscopy. 2021;53:1524
11.
Zurück zum Zitat Lucendo AJ, Molina-Infante J Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3):335-58 Lucendo AJ, Molina-Infante J Arias Á, et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017;5(3):335-58
12.
Zurück zum Zitat Lucendo AJ, Miehlke S, Schlag C et al. Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial. Gastroenterology. 2019;157:74-86.e15 Lucendo AJ, Miehlke S, Schlag C et al. Efficacy of Budesonide Orodispersible Tablets as Induction Therapy for Eosinophilic Esophagitis in a Randomized Placebo-Controlled Trial. Gastroenterology. 2019;157:74-86.e15
13.
Zurück zum Zitat Hirano I, Collins MH, Katzka DA et al. Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis: Results from a Phase 3 Trial. Clinical Gastroenterology and Hepatology 2021;20:525-34.e10 Hirano I, Collins MH, Katzka DA et al. Budesonide Oral Suspension Improves Outcomes in Patients With Eosinophilic Esophagitis: Results from a Phase 3 Trial. Clinical Gastroenterology and Hepatology 2021;20:525-34.e10
14.
Zurück zum Zitat Gómez-Torrijos E, García-Rodríguez R, Castro-Jiménez A et al. The efficacy of step-down therapy in adult patients with proton pump inhibitor-responsive oesophageal eosinophilia. Aliment Pharmacol Ther. 2016;43(4):534-40 Gómez-Torrijos E, García-Rodríguez R, Castro-Jiménez A et al. The efficacy of step-down therapy in adult patients with proton pump inhibitor-responsive oesophageal eosinophilia. Aliment Pharmacol Ther. 2016;43(4):534-40
15.
Zurück zum Zitat Laserna-Mendieta EJ, Casabona S, Guagnozzi D et al. Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry. Aliment Pharmacol Ther. 2020;52:798-807 Laserna-Mendieta EJ, Casabona S, Guagnozzi D et al. Efficacy of proton pump inhibitor therapy for eosinophilic oesophagitis in 630 patients: results from the EoE connect registry. Aliment Pharmacol Ther. 2020;52:798-807
16.
Zurück zum Zitat Lucendo AJ, Arias Á, González-Cervera J, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: A prospective study on the food cause of the disease. J Allergy Clin Immunol. 2013;131(3):797-804 Lucendo AJ, Arias Á, González-Cervera J, et al. Empiric 6-food elimination diet induced and maintained prolonged remission in patients with adult eosinophilic esophagitis: A prospective study on the food cause of the disease. J Allergy Clin Immunol. 2013;131(3):797-804
17.
Zurück zum Zitat Groetch M, Venter C, Skypala I et al. Dietary Therapy and Nutrition Management of Eosinophilic Esophagitis: A Work Group Report of the American Academy of Allergy, Asthma, and Immunology. J Allergy Clin Immunol Pract. 2017;5:312-24.e29 Groetch M, Venter C, Skypala I et al. Dietary Therapy and Nutrition Management of Eosinophilic Esophagitis: A Work Group Report of the American Academy of Allergy, Asthma, and Immunology. J Allergy Clin Immunol Pract. 2017;5:312-24.e29
18.
Zurück zum Zitat Straumann A, Lucendo AJ, Miehlke S et al. Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis. Gastroenterology. 2020;159:1672-85.e5 Straumann A, Lucendo AJ, Miehlke S et al. Budesonide Orodispersible Tablets Maintain Remission in a Randomized, Placebo-Controlled Trial of Patients With Eosinophilic Esophagitis. Gastroenterology. 2020;159:1672-85.e5
19.
Zurück zum Zitat Molina-Infante J, Rodriguez-Sanchez J, Martinek J et al. Long-Term Loss of Response in Proton Pump Inhibitor-Responsive Esophageal Eosinophilia Is Uncommon and Influenced by CYP2C19 Genotype and Rhinoconjunctivitis. Am J Gastroenterol. 2015;110:1567-75 Molina-Infante J, Rodriguez-Sanchez J, Martinek J et al. Long-Term Loss of Response in Proton Pump Inhibitor-Responsive Esophageal Eosinophilia Is Uncommon and Influenced by CYP2C19 Genotype and Rhinoconjunctivitis. Am J Gastroenterol. 2015;110:1567-75
20.
Zurück zum Zitat Dellon ES, Rothenberg ME, Collins MH et al. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. N Engl J Med. 2022;387(25):2317-30 Dellon ES, Rothenberg ME, Collins MH et al. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. N Engl J Med. 2022;387(25):2317-30
21.
Zurück zum Zitat Biedermann L, Straumann A, Greuter T et al. Eosinophilic esophagitis established facts and new horizons. Semin Immunopathol. 2021;43,319-35 Biedermann L, Straumann A, Greuter T et al. Eosinophilic esophagitis established facts and new horizons. Semin Immunopathol. 2021;43,319-35
Metadaten
Titel
Immunvermittelte Inflammation der Speiseröhre
Pathophysiologie, Diagnostik und Therapie der eosinophilen Ösophagitis
verfasst von
Prof. Dr. med. habil. Ahmed Madisch
Prof. Dr. med. Martin Storr
Publikationsdatum
16.06.2023
Verlag
Springer Medizin
Erschienen in
Gastro-News / Ausgabe 3/2023
Print ISSN: 1869-1005
Elektronische ISSN: 2520-8667
DOI
https://doi.org/10.1007/s15036-023-3230-2

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