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01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Critical Care 1/2018

Epidemiology of subsequent bloodstream infections in the ICU

Zeitschrift:
Critical Care > Ausgabe 1/2018
Autoren:
Niccolò Buetti, Elia Lo Priore, Rami Sommerstein, Andrew Atkinson, Andreas Kronenberg, Jonas Marschall, the Swiss Centre for Antibiotic resistance (ANRESIS)
Wichtige Hinweise

Electronic supplementary material

The online version of this article (https://​doi.​org/​10.​1186/​s13054-018-2148-0) contains supplementary material, which is available to authorized users.

Letter

A recently published review on the management of catheter-related infection highlighted the clinical importance of a positive catheter culture without concomitant positive blood cultures in the ICU [ 1]. Recently, we conducted a nationwide, observational study on all positive intravascular catheter (IVC) tip cultures in Switzerland investigating subsequent bloodstream infections (i.e., bloodstream infection occurring after the catheter has been removed) with non-ICU and ICU data [ 2]. Interestingly, the studies investigating this topic reported either data from an individual hospital [ 1] or focused on single pathogens [ 3, 4]. Moreover, only one observational study studied the ICU population [ 5]. Based on the Swiss Antibiotic Resistance Surveillance System (ANRESIS), we aimed to describe the current epidemiology of culture-positive IVC tips without concurrent bacteremia in the ICU and to characterize bacteremia or fungemia occurring after catheter removal.
We conducted a nationwide surveillance study on all positive IVC tip cultures recovered in Swiss ICUs (36 hospitals) from 2008 to 2015. An IVC tip culture, which required IVC removal, was included in the analysis if at least one microorganism could be cultivated. We excluded data from patients with concurrent bacteremia and fungemia with the same microorganism identified 7 days before to 2 days after IVC removal (623 cases). Subsequent bloodstream infection (sBSI) was defined as isolating (from blood cultures performed > 2 days up to 7 days after IVC removal) the same microorganism as the one recovered from the IVC tip.
Over the 8-year period, 2,941 positive IVC tip cultures without concurrent bacteremia were identified in ICUs. In 3.1% (92/2,941, 95% confidence interval 2.5–3.8) of removed catheters an sBSI was observed (Fig.  1). Among bacterial microorganisms, Serratia marcescens (4/40, 10%, 3.3–24), Staphylococcus aureus (7/88, 8.0%, 3.5–16.2) and Pseudomonas aeruginosa (4/81, 4.9%, 1.6–12.8) were the most frequently identified agents causing sBSI. Subsequent fungemia developed in 8/29 (27.6%, 11.3–43.9) IVC tips positive for fungi (Additional file  1: Table S1). Enterococci rarely caused sBSI (1.6%, 0.5–4.2).
To our knowledge, ours is the largest epidemiologic description of sBSI in this setting. Our findings highlight that particular attention should be paid if Candida albicans, S. aureus, S. marcescens, and P. aeruginosa are detected on an IVC tip. The presence of these four microorganisms is associated with a higher frequency of sBSI than other microorganisms and, therefore, a short treatment may need to be considered by intensive care physicians. In contrast, enterococci represented the lowest risk for sBSI and probably do not require specific antimicrobial therapy.

Acknowledgments

We thank all microbiology laboratories participating in the ANRESIS network: Institute for Laboratory Medicine, Cantonal Hospital Aarau; Central Laboratory, Microbiology Section, Cantonal Hospital Baden; Clinical Microbiology, University Hospital Basel; Viollier AG, Basel; Laboratory Medicine EOLAB, Department of Microbiology, Bellinzona; Institute for Infectious Diseases, University Bern; Microbiology Laboratory, Unilabs, Coppet; Central Laboratory, Cantonal Hospital Graubünden; Microbiology Laboratory, Hospital Thurgau; Microbiology Laboratory Hôpital Fribourgeois, Fribourg; Bacteriology Laboratory, Geneva University Hospitals, Geneva; ADMED Microbiology, La Chaux-de-Fonds; Institute for Microbiology, Université de Lausanne; Centre for Laboratory Medicine, Cantonal Hospital Luzern; Centre for Laboratory Medicine, Cantonal Hospital Schaffhausen; Centre for Laboratory Medicine Dr. Risch, Schaan; Central Institute, Hôpitaux Valaisans (ICHV), Sitten; Centre of Laboratory Medicine St. Gallen; Institute for Medical Microbiology, University Hospital Zürich; Laboratory for Infectious Diseases, University Children’s Hospital Zürich.
We would also like to thank the steering committee of ANRESIS.
ANRESIS collaboration group: A. Burnens, Synlab Suisse, Switzerland; A. Cherkaoui, Bacteriology Laboratory, Geneva University Hospitals, Switzerland; V. Gaia, Department of Microbiology, EOLAB, Bellinzona, Switzerland; O. Dubuis, Viollier AG, Basel, Switzerland; A. Egli, Clinical Microbiology Laboratory, University Hospital Basel, Switzerland; D. Koch, Federal Office of Public Health, Bern, Switzerland; A. Kronenberg, Institute for Infectious Diseases, University of Bern, Switzerland; P. Nordmann, Molecular and Medical Microbiology, Department of Medicine, University Fribourg, Switzerland; V. Perreten, Institute of Veterinary Bacteriology, University of Bern, Switzerland; J.-C. Piffaretti, Interlifescience, Massagno, Switzerland; G. Prod’hom, Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; J. Schrenzel, Bacteriology Laboratory, Geneva University Hospitals, Geneva, Switzerland; S. L. Leib, Institute for Infectious Diseases, University of Bern, Switzerland; A. F. Widmer, Division of Infectious Diseases & Hospital Epidemiology, University of Basel, Switzerland; G. Zanetti, Service of Hospital Preventive Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland; R. Zbinden, Institute of Medical Microbiology, University of Zürich, Switzerland.

Funding

The ANRESIS database is funded by the Federal Office of Public Health, and the University of Bern, Switzerland.

Availability of data and materials

The datasets generated and/or analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.

Ethics approval and consent to participate

As the analysis was performed on anonymized non-genetic surveillance data, ethical consent was not required according to the Swiss law for research on humans (Art. 33 al. 2 LRH).

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

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Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://​creativecommons.​org/​licenses/​by/​4.​0/​), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://​creativecommons.​org/​publicdomain/​zero/​1.​0/​) applies to the data made available in this article, unless otherwise stated.
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