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Endocrine
Erschienen in: Endocrine 1/2014

01.09.2014 | Review

Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH

verfasst von: Craig S. Nunemaker, Leslie S. Satin

Erschienen in: Endocrine | Ausgabe 1/2014

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Abstract

Rhythms govern many endocrine functions. Examples of such rhythmic systems include the insulin-secreting pancreatic beta-cell, which regulates blood glucose, and the gonadotropin-releasing hormone (GnRH) neuron, which governs reproductive function. Although serving very different functions within the body, these cell types share many important features. Both GnRH neurons and beta-cells, for instance, are hypothesized to generate at least two rhythms endogenously: (1) a burst firing electrical rhythm and (2) a slower rhythm involving metabolic or other intracellular processes. This review discusses the importance of hormone rhythms to both physiology and disease and compares and contrasts the rhythms generated by each system.
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Metadaten
Titel
Episodic hormone secretion: a comparison of the basis of pulsatile secretion of insulin and GnRH
verfasst von
Craig S. Nunemaker
Leslie S. Satin
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 1/2014
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-014-0212-3

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Fast ein Viertel der Personen mit mäßig dysplastischen Stimmlippenläsionen entwickelt einen Kehlkopftumor. Solche Personen benötigen daher eine besonders enge ärztliche Überwachung.

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Ob Patienten und Patientinnen mit neu diagnostiziertem Blasenkrebs ein Jahr später Bedauern über die Therapieentscheidung empfinden, wird einer Studie aus England zufolge von der Radikalität und dem Erfolg des Eingriffs beeinflusst.

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„Kalte“ Tumoren werden heiß – CD28-kostimulatorische Antikörper sollen dies ermöglichen. Am besten könnten diese in Kombination mit BiTEs und Checkpointhemmern wirken. Erste klinische Studien laufen bereits.

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