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28.05.2022 | Original Article

Episodic memory in progressive supranuclear palsy: a neuropsychological and neuroimaging study

verfasst von: Arthur Cassa Macedo, Paulo Caramelli, Elisa de Paula França Resende, Luciano Inácio Mariano, Vítor Tumas, Antônio Lúcio Teixeira, Sarah Teixeira Camargos, Francisco Eduardo Costa Cardoso, Leonardo Cruz de Souza

Erschienen in: Neurological Sciences | Ausgabe 9/2022

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Abstract

Background

Episodic memory impairment may occur in progressive supranuclear palsy (PSP). However, it remains uncertain whether this is due to executive dysfunction or to the involvement of brain areas responsible for memory.

Objectives

To investigate the specific brain regions underlying episodic memory impairment in PSP.

Methods

Twenty-one patients with PSP and 20 healthy controls underwent the Figure Memory Test (FMT) from the Brief Cognitive Screening Battery and brain MRI. We explored correlations between gray matter volumes and memory scores in PSP patients, adjusting for age and performance on the Frontal Assessment Battery.

Results

PSP patients performed worse than controls (p < 0.001) on delayed recall in the FMT. Delayed recall scores correlated to bilateral hippocampal and parahippocampal volumes in PSP patients.

Conclusions

Medial temporal structures may play a role in episodic memory impairment in PSP, suggesting that amnesia in PSP is not solely due to executive dysfunction.

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Titel: Episodic memory in progressive supranuclear palsy: a neuropsychological and neuroimaging study
verfasst von: Arthur Cassa Macedo
Paulo Caramelli
Elisa de Paula França Resende
Luciano Inácio Mariano
Vítor Tumas
Antônio Lúcio Teixeira
Sarah Teixeira Camargos
Francisco Eduardo Costa Cardoso
Leonardo Cruz de Souza
Publikationsdatum: 28.05.2022
Verlag: Springer International Publishing
Erschienen in: Neurological Sciences / Ausgabe 9/2022
Print ISSN: 1590-1874
Elektronische ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-022-06160-2

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Abstract

Background

Objectives

Methods

Results

Conclusions

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