Erschienen in:
01.12.2009 | Case Report
Epstein-Barr virus associated primary intracranial leiomyoma in organ transplant recipient: case report and review of the literature
verfasst von:
Dimitris Zevgaridis, Christos Tsonidis, Nikiforos Kapranos, Ioannis Venizelos, Parmenion Tsitsopoulos, Philippos Tsitsopoulos
Erschienen in:
Acta Neurochirurgica
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Ausgabe 12/2009
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Abstract
Introduction
A 45 year old female renal transplant recipient presented with headaches of 3 months duration. Clinical and radiological evaluation revealed an approximately 4x4cm rounded, enhancing mass at the left temporal pole. At surgery, the mass had dural attachment and clinically, radiographically, and macroscopically resembled a meningioma. Histopathological analysis revealed a leiomyoma. Epstein-Barr virus (EBV) DNA was demonstrated within the tumour cell nuclei by the in situ hybridisation technique.
Discussion
This is the first documentation of an EBV-associated primary intracranial leiomyoma in an organ transplant recipient and provides additional evidence of a possible relation between EBV infection and development of smooth-muscle tumours (SMT).
Conclusion
With increasing numbers of individuals being on long-term immuno-suppression, EBV-associated SMTs may be encountered more frequently in the future.