Fig. 2
Proposed algorithm for adjusting antidiabetic agents (a) and diuretic/antihypertensive therapy (b) when initiating SGLT2 inhibitors in patients with type 2 diabetes. DPP4i DPP4 inhibitors, GI gastrointestinal, GLP1ra GLP-1 receptor agonists, SU sulfonylureas, SMBG self-monitoring of blood glucose, BP blood pressure. *Avoid insulin withdrawal to minimize the risk of euglycemic diabetic ketoacidosis. **Hemodynamically unstable defined as atrial fibrillation, orthostatic hypotension or blood pressure lability, prior syncope, etc. ***Clinical situation defined by congestive heart failure, edema, renal function