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Endocrine

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01.12.2011 | Original Article

Estradiol-17β modulates dose-dependently hypothalamic tyrosine hydroxylase activity inhibited by α-methylparatyrosine in the catfish Heteropneustes fossilis

verfasst von: Radha Chaube, Keerikkattil P. Joy

Erschienen in: Endocrine | Ausgabe 3/2011

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Abstract

The brain is a target for organizational and activational effects of oestrogens synthesized de novo or transported from the peripheral organs. A neuroprotective role of oestrogens has been documented in a variety of vertebrates. In the present study in the catfish Heteropneustes fossilis, we have demonstrated that estradiol-17β (E₂), the major circulating oestrogen at low dosages (0.05 and 0.1 μg/g body weight of fish for 3 days) stimulated hypothalamic tyrosine hydroxylase (TH) activity, and countered the negative effects of ovariectomy (3-week) or α-methylparatyrosine (α-MPT: 250 μg/g body weight, a competitive inhibitor of TH). In contrast, high dosages of E₂ (1 and 2 μg/g body weight of fish for 3 days) were inhibitory and further amplified the inhibitory effects of ovariectomy and α-MPT. The inhibiting role of E₂ was higher in gonad-active (prespawning) phase than gonad-inactive (resting phase) phase. The dual roles of E₂ may ensure a tight regulation of catecholaminergic activity, activating and inhibiting the system against wide fluctuations that are characteristic of seasonally breeding animals.

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Titel: Estradiol-17β modulates dose-dependently hypothalamic tyrosine hydroxylase activity inhibited by α-methylparatyrosine in the catfish Heteropneustes fossilis
verfasst von: Radha Chaube
Keerikkattil P. Joy
Publikationsdatum: 01.12.2011
Verlag: Springer US
Erschienen in: Endocrine / Ausgabe 3/2011
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI: https://doi.org/10.1007/s12020-011-9543-5

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