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Lasers in Medical Science

Erschienen in:

23.03.2021 | Original Article

Evaluation of Na and K in anti-diabetic ayurvedic medicine using LIBS

verfasst von: Reshu Kumari, Rohit Kumar, Apeksha Rai, Awadhesh Kumar Rai

Erschienen in: Lasers in Medical Science | Ausgabe 1/2022

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Abstract

Diabetes mellitus, known as diabetes, is a challenging issue, and to control diabetes, a large population is lining toward ayurvedic medicine. In the present study, four brands of anti-diabetic ayurvedic medicines, along with a home remedy, are analyzed using the laser-induced breakdown spectroscopic (LIBS) technique. The study is carried out to know the elements responsible for glycemic potential. The laser-induced breakdown (LIB) spectra elucidate the presence of organic and inorganic elements like Al, Ba, C, Ca, Cu, Fe, H, K, Mg, N, Na, O, Si, Sr, Zn, and the molecular band of CN molecule in medicines. LIBS result also reveals Na and K’s distinct concentration, which plays a vital role in diabetes management. The presence of the CN band and organic elements indicate the presence of organic molecular compositions in medicines. For confirmation of organic composition in the drugs, Fourier transform infrared spectroscopy (FT-IR) has been performed. Principal component analysis (PCA) on the LIBS data of the medicines has been used for instant discrimination based on their elemental/molecular compositions.

International diabetes federation (2019) IDF diabetes Atlas ninth edition 2019.

KGK D, Neelapu NRR, Challa S (2014) Role of anti-diabetic compounds on glucose metabolism—a special focus on medicinal plant: Salacia sps. Med Chem 4(3):373–381. https://doi.org/10.4172/2161-0444.1000168CrossRef

World Health Organisation (2020) World health statistics 2020: monitoring health for the SDGs, sustainable development goals.

Mishal A, Saravanan R, Atchitha SS, Santhiya K, Rithika M, Menaka SS, Thiruvalluvan T (2020) Effect of Gymnema sylvestre leaf extract on Streptozotocin induced diabetic rats. J Pharmacogn Phytochem 9(4):20–23. https://doi.org/10.22271/phyto.2020.v9.i4a.11663CrossRef

Muruganandan S, Srinivasan K, Gupta SB, Gupta PK, Lal J (2005) Effect of mangiferin on hyperglycemia and atherogenicity in streptoztocin diabetic rats. J Ethnopharmacol 97(3):497–501. https://doi.org/10.1016/j.jep.2004.12.010CrossRefPubMed

Joseph B, Devi J (2013) Anti-diabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac J Trop Dis 3(2):93–102. https://doi.org/10.1016/S2222-1808(13)60052-3CrossRefPubMedCentral

Jaiswal D, Rai PK, Kumar A, Mehta S, Watal G (2009) Effect of Moringa oleifera Lam. Leaves aqueous extract therapy on hyperglycemic rats. J Ethnopharmacol 123(3):25:392–25:396. https://doi.org/10.1016/j.jep.2009.03.036CrossRef

Perera HKI (2016) Antidiabetic Effects of Pterocarpus marsupium (Gammalu). European J Med plants 13(4):1–14. https://doi.org/10.9734/EJMP/2016/23930CrossRef

Li Y, Huang THW, Yamahara J (2008) Salacia root, a unique Ayurvedic medicine, meets multiple targets in diabetes and obesity. Life Sci 82(21-22):1045–1049. https://doi.org/10.1016/j.lfs.2008.03.005CrossRefPubMed

10.

Kumar A, Ilavarasan R, Jayachandran T, Deecaraman M, Aravindan P, Padmanabhan N, Krishan MRV (2008) Anti-diabetic activity of Syzygium cumini and its isolated compound against streptozotocin-induced diabetic rats. J Med Plant Res 2(9):246–249. https://doi.org/10.5897/JMPR.9000093CrossRef

11.

Dalipi R, Borgese L, Tsuji K, Bontempi E, Depero LE (2018) Elemental analysis of teas, herbs and their infusions by means of total reflection X-ray fluorescence. J Food Compos Anal 67:128–134. https://doi.org/10.1016/j.jfca.2018.01.010CrossRef

12.

Santos Junior AF, Matos RA, Andrade EMJ, Santos WNL, Magalhaes HIF, Costac FN, Korn MGA (2017) Multielement determination of macro and micro contents in medicinal plants and phytomedicines from Brazil by ICP-OES. J Braz Chem Soc 28(2):376–384. https://doi.org/10.5935/0103/-5053.20160187CrossRef

13.

Suryawanshi RP, Kamat SS (2016) Metal determination from medicinal herbal product of sarpgandha by AAS (Atomic absorption spectrophotometry). World J. Pharm Res 5(5):1741–1750. https://doi.org/10.20959/wjpr20165-6241CrossRef

14.

Kilic S, Soylak M (2020) Determination of trace element contaminants in herbal teas using ICP-MS by different sample preparation method. J Food Sci Technol 57(3):927–933. https://doi.org/10.1007/s13197-019-04125-6CrossRefPubMed

15.

Rai NK, Rai PK, Pandhija S, Watal G, Rai AK, Bicanic D (2009) Application of LIBS in detection of antihyperglycemic trace elements in Momordica charantia. Food Biophys 4:167–171. https://doi.org/10.1007/s11483-009-9114-yCrossRef

16.

Tiwari PK, Rai NK, Kumar R, Parigger CG, Rai AK (2019) Atomic and molecular laser-induced breakdown spectroscopy of selected pharmaceuticals. Atoms 7(3):71. https://doi.org/10.3390/atoms7030071CrossRef

17.

Tiwari M, Agrawal R, Pathak AK, Rai AK, Rai GK (2013) Laser-induced breakdown spectroscopy: an approach to detect adulteration in turmeric. Spectrosc Lett 46(3):155–159. https://doi.org/10.1080/00387010.2012.702707CrossRef

18.

Zhang C, Shen T, Liu F, He Y (2018) Identification of coffee varieties using laser-induced breakdown spectroscopy and chemometrics. Sensors 18(1):95. https://doi.org/10.3390/s18010095CrossRef

19.

Nisar S, Dastgeer G, Shafiq M, Usman M (2018) Qualitative and semi-quantitative analysis of health-care pharmaceutical products using laser-induced breakdown spectroscopy. J Pharm Anal 9:20–24. https://doi.org/10.1016/j.jpha.2018.10.003CrossRefPubMedPubMedCentral

20.

Aldakheel RK, Gondal MA, Nasr MM, Almessiere MA, Idris N (2020) Spectral analysis of Miracle Moringa tree leaves using X-ray photoelectron, laser induced breakdown and inductively coupled plasma-optical emission spectroscopic techniques. Talanta. 217:121062. https://doi.org/10.1016/j.talanta.2020.121062CrossRefPubMed

21.

Wang J, Li X, Zheng P, Zheng S, Mao X, Zhao H, Liu R (2020) Characterization of the Chinese traditional medicine Artemisia annua by laser-induced breakdown spectroscopy (LIBS) with 532 nm and 1064 nm excitation. Anal Lett 53:922–936. https://doi.org/10.1080/00032719.2019.1686511CrossRef

22.

Kara D (2009) Evaluation of trace metal concentration in some herbs and herbal teas by principal component analysis.Food. Chem 114(1):347–354. https://doi.org/10.1016/j.foodchem.2008.09.054CrossRef

23.

Tiwari PK, Awasthi S, Kumar R, Anand RK, Rai PK, Rai AK (2018) Rapid analysis of pharmaceutical drugs using LIBS coupled with multivariate analysis. Lasers Med Sci 33:263–270. https://doi.org/10.1007/s10103-017-2358-8CrossRefPubMed

24.

National Institute of Standards and Technology USA (NIST) Electronic database. http;//physics.nist.gov/physRefData/ASD/lines_form.html

25.

Pearse RWB, Gydon AG. The identification of molecular spectra

26.

Diaconu D, Diaconu R, Navrotescu T (2012) Estimation of heavy metals in medicinal plants and their infusions. Ovi Uni Annals Chem 23(1):115–120. https://doi.org/10.2478/v10310-012-0019-0CrossRef

27.

Sarma H, Deka S, Deka H, Saikia RR (2012) Accumulation of heavy metals in selected medicinal plants. Rev Environ Contam Toxicol 214:63–86. https://doi.org/10.1007/978-1-4614-0668-6_4CrossRef

28.

Marie PJ, Ammann P, Boivin G, Rey C (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69(3):121–129. https://doi.org/10.1007/s002230010055CrossRefPubMed

29.

Rai PK, Jaiswal D, Rai NK, Pandhija S, Rai AK, Geeta W (2009) Role of glycemic elements of Cynodon dactylon and Musa paradisiaca in diabetes management. Lasers Med Sci 24:761–768. https://doi.org/10.1007/s10103-008-0637-0CrossRefPubMed

30.

Rai PK, Rai NK, Rai AK, Watal G (2007) Role of LIBS in elemental analysis of Psidium guajava responsible for glycemic potential. Instrum Sci Technol 35(5):507–522. https://doi.org/10.1080/10739140701540230CrossRef

31.

Serrano J, Moros J, Laserna JJ (2016) Molecular signatures in femtosecond laser-induced organic plasmas: comparison with nanosecond laser ablation. Phys Chem Chem Phys 18:2398–2408. https://doi.org/10.1039/C5CP06456BCrossRefPubMed

32.

Akbari S, Bayat M, Roudbarmohammadi S, Hashemi J (2019) Chitosan nanogel design on Gymnema sylvestre essential oils to inhibit growth of Candida albicans biofilm and investigation of gene expression ALS1, ALS3. Period. Polytech. Chem. Eng 63(4):569–581. https://doi.org/10.3311/PPch.12519CrossRef

33.

Varadharaj V, Ramaswamy A, Sakthivel R, Subbaiya R, Barabadi H, Chandrasekaran M, Saravanan M (2019) Anti-diabetic and antioxidant activity of green synthesized starch nanoparticles: an in vitro study. J Clust Sci. https://doi.org/10.1007/s10876-019-01732-3

34.

Ahamed AJ, Kumar PV, Loganathan K, Karthikeyan C, Hameed ASH (2016) Synthesis, characterization and cytotoxicity studies of CuO nanoparticles by using Gymnema sylvestre leaf extracts. J Indian Chem Soc 93:655–660

35.

Yadav SS, Meshram GA, Shinde D, Patil RC, Manohar SM, Upadhye MV (2011) Antibacterial and anticancer activity of bioactive fraction of Syzygium cumini L. Seed Hayati 18(3):118–122. https://doi.org/10.4308/hjb.18.3.118CrossRef

36.

Kanwal F, Batool A, Rasool S, Naseem S, Rehman R (2014) Synthesis of Polyaniline composites with grinded leaves of Polyalthia longifolia, Syzygium cumini, Alstonia scholaris and Madhuca longifolia and study of their structural, electrical and dielectric properties. Asian J Chem 26(22):7519–7522 https://doi.org/10.14233/ajchem.2014.16649CrossRef

37.

Kumar V, Yadav SK (2012) Characterization of gold nanoparticles synthesized by leaf and seed extract of Syzygium cumini L. J Exp Nanosci 7(4):440–451. https://doi.org/10.1080/17458080.2010.543989CrossRef

38.

Dogo DW, Louis H, Iliya NI, Ozioma AU, Aderemi AT, Tsware BJ (2019) Swelling kinetics of poly (N-isopropylacrylamide)-based hydrogel and its application as anti-diabetic drugs delivery system. J Med Chem Sci 2:162–171

39.

Myakalwar AK, Sreedhar S, Barman I, Dingari NC, Rao SV, Kiran PP, Tewari SP, Gundawar MK (2011) Laser induced breakdown spectroscopy- based investigation and classification of pharmaceutical tablets using multivariate chemometric analysis. Talanta 87:53–59. https://doi.org/10.1016/j.talanta.2011.09.040CrossRefPubMedPubMedCentral

Titel: Evaluation of Na and K in anti-diabetic ayurvedic medicine using LIBS
verfasst von: Reshu Kumari
Rohit Kumar
Apeksha Rai
Awadhesh Kumar Rai
Publikationsdatum: 23.03.2021
Verlag: Springer London
Erschienen in: Lasers in Medical Science / Ausgabe 1/2022
Print ISSN: 0268-8921
Elektronische ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-021-03289-y

Springer Medizin

Abstract

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