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17.12.2018 | Magnetic Resonance

Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging

verfasst von: Jiule Ding, Zhaoyu Xing, Zhenxing Jiang, Hua Zhou, Jia Di, Jie Chen, Jianguo Qiu, Shengnan Yu, Liqiu Zou, Wei Xing

Erschienen in: European Radiology | Ausgabe 5/2019

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Abstract

Objective

To explore the value of texture analysis based on diffusion-weighted imaging (DWI), blood oxygen level–dependent MRI (BOLD), and susceptibility-weighted imaging (SWI) in evaluating renal dysfunction.

Methods

Seventy-two patients (mean age 53.72 ± 13.46 years) underwent MRI consisting of DWI, BOLD, and SWI. According to their estimated glomerular filtration rate (eGFR), the patients were classified into either severe renal function impairment (sRI, eGFR < 30 mL/min/1.73 m²), non-severe renal function impairment (non-sRI, eGFR ≥ 30 mL/min/1.73 m², and < 80 mL/min/1.73 m²), or control (CG, eGFR ≥ 80 mL/min/1.73 m²) groups. Thirteen texture features were extracted and then were analyzed to select the most valuable for discerning the three groups with each imaging method. A ROC curve was performed to compare the capacities of the features to differentiate non-sRI from sRI or CG.

Results

Six features proved to be the most valuable for assessing renal dysfunction: 0.25Quantile_DWI, 0.5Quantile_DWI, Homogeneity_DWI, Entropy_BOLD, Skewness_SWI, and Correlation_SWI. Three features derived from DWI (0.25Quantile_DWI, 0.5Quantile_DWI, and Homogeneity_DWI) were smaller in sRI than in non-sRI; Entropy_BOLD and Correlation_SWI were smaller in non-sRI than in CG (p < 0.05). 0.25Quantile_DWI, 0.5Quantile_DWI, and Homogeneity_DWI showed similar capacities for differentiating sRI from non-sRI. Similarly, Entropy_BOLD and Correlation_SWI showed equal capacities for differentiating non-sRI from CG.

Conclusion

Texture analysis based on DWI, BOLD, and SWI can assist in assessing renal dysfunction, and texture features based on BOLD and SWI may be suitable for assessing renal dysfunction during early stages.

Key Points

• Texture analysis based on MRI techniques allowed for assessing renal dysfunction.

• Texture features based on BOLD and SWI, but not DWI, may be suitable for assessing renal function impairment during early stages.

• SWI exhibited a similar capacity to BOLD for assessing renal dysfunction.

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Titel: Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging
verfasst von: Jiule Ding
Zhaoyu Xing
Zhenxing Jiang
Hua Zhou
Jia Di
Jie Chen
Jianguo Qiu
Shengnan Yu
Liqiu Zou
Wei Xing
Publikationsdatum: 17.12.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: European Radiology / Ausgabe 5/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5911-3

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Evaluation of renal dysfunction using texture analysis based on DWI, BOLD, and susceptibility-weighted imaging