Background
Methods
Study design and settings
Diagnoses of diseases
Cases and controls
Data collection
Statistical analyses
Results
Case subjects (those with perforation) | Control subjects (those without perforation) | p-value | |
---|---|---|---|
n = 136 | n = 272 | ||
Patients’ demographics | |||
Agea, year (SD) | 56.2 (16.5) | 56.2 (16.5) | 1.00 |
Malea, n (%) | 116 (85.3) | 232 (85.3) | 1.00 |
Smoking, n (%) | 98 (72.1) | 114 (41.9) |
< 0.01
|
Regular alcohol consumption, n (%) | 75 (55.1) | 112 (41.2) | 0.48 |
Medical history | |||
Gastrointestinal history | |||
Peptic ulcer disease, n (%) |
45 (33.1)
|
27 (9.9)
|
< 0.01
|
Gastroesophageal reflux disease, n (%) | 2 (1.5) | 4 (1.5) | 1.00 |
Crohn’s disease, n (%) | 0 (0.0) | 0 (0.0) | N/A |
Ulcerative colitis, n (%) | 1 (0.7) | 1 (0.4) | 1.00 |
H. pylori infection, n (%) |
9 (6.6)
|
1 (0.4)
|
< 0.01
|
Adnominal operation, n (%) | 38 (27.9) | 74 (27.2) | 0.91 |
Prior ESDb, n (%) | 1 (0.7) | 1 (0.4) | 1.00 |
Other history | |||
Hypertension, n (%) | 34 (25.0) | 68 (25.0) | 1.00 |
Diabetes mellitus, n (%) | 19 (14.0) | 32 (11.8) | 0.53 |
Dyslipidemia, n (%) | 12 (8.8) | 42 (15.4) | 0.07 |
Cancer baring, n (%) | 17 (12.5) | 31 (11.4) | 0.75 |
Under chemotherapy, n (%) | 8 (5.9) | 8 (2.9) | 0.18 |
Chronic obstructive pulmonary disease, n (%) |
0 (0.0)
|
9 (3.3)
|
0.03
|
Cirrhosis, n (%) | 2 (1.5) | 3 (1.1) | 1.00 |
Case subjects (those with perforation) | Control subjects (those without perforation) | p-value | |
---|---|---|---|
n = 136 | n = 272 | ||
Physical finding & Symptom | |||
Location of pain | |||
Abdominal pain |
< 0.01
| ||
No pain, n (%) | 13 (9.6) | 94 (34.6) | |
Upper abdomen, n (%) | 59 (43.4) | 82 (30.1) | |
Mid abdomen, n (%) | 9 (6.6) | 39 (14.3) | |
Lower abdomen, n (%) | 11 (8.1) | 47 (17.3) | |
Multiple abdomen, n (%) |
44 (32.4)
|
10 (3.7)
| |
Chest pain, n (%) | 2 (1.5) | 14 (5.1) | 0.10 |
Back pain, n (%) | 15 (11.0) | 22 (8.1) | 0.36 |
Other Associated Symptoms | |||
Loss of appetite, n (%) |
33 (24.3)
|
39 (14.3)
|
0.02
|
Vomiting, n (%) | 42 (30.9) | 82 (30.1) | 0.91 |
Nausea, n (%) | 51 (37.5) | 81 (29.8) | 0.12 |
Hematemesis, n (%) | 10 (7.4) | 8 (2.9) | 0.07 |
Constipation, n (%) | 11 (8.1) | 16 (5.9) | 0.40 |
Diarrhea, n (%) |
9 (6.6)
|
49 (18.0)
|
< 0.01
|
Hematochezia/melena, n (%) | 24 (17.6) | 38 (14.0) | 0.38 |
Dizziness, n (%) | 8 (5.9) | 21 (7.7) | 0.55 |
Perspiration, n (%) | 20 (14.7) | 34 (12.5) | 0.54 |
Pallor, n (%) | 8 (5.9) | 12 (4.4) | 0.63 |
Respiratory distress, n (%) | 9 (6.6) | 17 (6.3) | 1.00 |
Muscular defense, n (%) |
93 (68.4)
|
25 (9.2)
|
< 0.01
|
Case subjects (those with perforation) | Control subjects (those without perforation) | p-value | |
---|---|---|---|
n = 136 | n = 272 | ||
Medications | |||
Antiplatelet, n (%) | 0.78 | ||
None, n (%) | 127 (93.4) | 256 (94.1) | |
Aspirin, n (%) | 6 (4.4) | 11 (4.0) | |
Clopidogrel, n (%) | 0 (0.0) | 1 (0.4) | |
Limaprost alfadex, n (%) | 0 (0.0) | 1 (0.4) | |
Dual Antiplatelet Therapy, n (%) | 3 (2.2) | 3 (1.1) | |
Anticoagulant, n (%) | 7 (5.1) | 9 (3.3) | 0.42 |
NSAIDs daily, n (%) |
15 (11.0)
|
13 (4.8)
|
0.02
|
NSAIDs rescue, n (%) | 11 (8.1) | 16 (5.9) | 0.40 |
Proton pump inhibitor, n (%) | 10 (7.4) | 21 (7.7) | 1.00 |
H2 blocker, n (%) | 1 (0.7) | 10 (3.7) | 0.11 |
Bisphosphonate, n (%) | 4 (2.9) | 3 (1.1) | 0.23 |
Spironolactone, n (%) | 1 (0.7) | 7 (2.6) | 0.28 |
Steroid, n (%) | 5 (3.7) | 8 (2.9) | 0.77 |
Case subjects (those with perforation) | Control subjects (those without perforation) | p-value | |
---|---|---|---|
n = 136 | n = 272 | ||
Vital signs | |||
Systolic blood pressure (SD) | 130.4 (24.0) | 133.5 (28.2) | 0.39 |
Diastolic blood pressure (SD) | 74.1 (18.5) | 74.3 (16.4) | 0.94 |
Respiratory rate (SD) |
20.2 (6.1)
|
18.2 (5.2)
|
0.01
|
Heart rate (SD) | 81.2 (15.8) | 80.7 (16.3) | 0.82 |
Body temperature (SD) | 36.6 (0.91) | 36.7 (0.97) | 0.27 |
Laboratory data (SD) | |||
White blood cell count (SD) |
10.7 (6.5)
|
9.2 (5.1)
|
0.01
|
Hemoglobin (SD) |
12.4 (4.8)
|
13.5 (3.2)
|
0.02
|
Platelet count (SD) |
220.0 (130.0)
|
175.5 (101.1)
|
< 0.01
|
Total protein (SD) |
6.8 (1.0)
|
7.1 (0.8)
|
0.02
|
Albumin (SD) |
3.8 (0.9)
|
4.0 (0.7)
|
0.04
|
Blood urea nitrogen (SD) | 19.7 (15.0) | 17.1 (13.1) | 0.10 |
Creatinine (SD) | 1.0 (0.9) | 1.0 (1.2) | 0.81 |
Total bilirubin (SD) | 0.8 (0.5) | 1.0 (1.2) | 0.06 |
AST (SD) |
23.6 (25.1)
|
47.1 (114.3)
|
< 0.01
|
ALT (SD) |
21.2 (18.5)
|
40.2 (76.8)
|
< 0.01
|
Sodium (SD) | 112.7 (50.9) | 121.3 (43.8) | 0.11 |
Potassium (SD) | 3.9 (0.5) | 4.0 (0.5) | 0.33 |
Chlorine (SD) | 27.5 (30.3) | 25.3 (30.0) | 0.50 |
C-reactive protein (SD) | 4.0 (8.2) | 3.2 (5.0) | 0.32 |
APTT (SD) | 25.9 (7.5) | 26.7 (9.2) | 0.39 |
PT (SD) | 8.8 (5.4) | 10.0 (6.5) | 0.11 |
Odds Ratios (95% Confidence Interval) | ||||
---|---|---|---|---|
Stepwise | Forced-entry | |||
Social History | Logistic | Conditional | Logistic | Conditional |
Smoking | 1.02 | 1.39 | ||
(0.45–2.31) | (0.42–4.64) | |||
Alcohol | 0.68 | 0.56 | ||
(0.31–1.50) | (0.19–1.62) | |||
Past Medical History | ||||
PUD |
7.81
|
21.9
|
3.67
|
6.40
|
(1.98–30.8)
|
(3.92–122.5)
|
(1.47–9.18)
|
(1.13–36.2)
| |
GERD |
256.7
| |||
(12.5–5274.1)
| ||||
Medications | ||||
NSAID daily use |
28.5
|
4.71
| 5.40 | |
(3.00–270.3)
|
(1.29–17.2)
| (0.55–53.5) | ||
NSAID rescue use |
0.05
| |||
(0.004–0.57)
| ||||
Antiplatelet |
5.90
|
2.37
| 3.20 | |
(2.59–13.4)
|
(1.29–4.34)
| (0.75–13.6) | ||
Anticoagulant | 1.04 | 0.85 | ||
(0.13–8.41) | (0.03–22.3) | |||
PPI* | 0.50 | 2.03 | ||
(0.13–1.86) | (0.24–16.9) | |||
Physical Findings | ||||
Location of pain No pain Reference | ||||
Upper abdomen |
4.40
| 1.90 | 2.61 | |
(1.10–17.7)
| (0.71–5.12) | (0.59–11.5) | ||
Mid abdomen | 2.20 | 1.23 | 2.47 | |
(0.28–16.6) | (0.28–5.45) | (0.13–46.6) | ||
Lower abdomen | 1.62 | 0.83 | 2.18 | |
(0.27–9.81) | (0.21–3.23) | (0.33–14.4) | ||
Multiple abdomen |
287.7
|
39.4
|
51.8
| |
(22.9–3619.8)
|
(8.79–176.3)
|
(3.57–752.9)
| ||
Muscular defense |
366.2
|
76.6
|
28.4
|
23.8
|
(61.9–2166.2)
|
(13.7–429.6)
|
(11.6–69.6)
|
(5.70–100.0)
| |
Back pain |
24.4
|
100.7
| ||
(3.30–180.6)
|
(7.05–1438.0)
| |||
Chest pain |
0.002
| |||
(0.00–0.12)
| ||||
Loss of appetite |
3.63
| 3.43 | ||
(1.40–9.46)
| (0.75–15.7) | |||
Hematemesis |
141.2
| |||
(7.02–2838.0)
| ||||
Diarrhea |
0.19
| |||
(0.04–0.89)
| ||||
H. Pylori infection |
1522.0
| |||
(14.4–160,502.9)
| ||||
Vomiting |
0.03
|
0.39
| 0.42 | |
(0.01–0.16)
|
(0.18–0.88)
| (0.12–1.44) | ||
Nausea |
9.69
| |||
(2.27–41.4)
| ||||
Laboratory Data | ||||
C-Reactive Protein |
1.13
| 1.04 | 1.02 | |
(1.05–1.22)
| (1.00–1.10) | (0.95–1.11) | ||
Platelet counts |
1.00
|
1.01
| ||
(1.01–1.01)
|
(1.00–1.01)
| |||
Hemoglobin |
0.75
|
0.78
| ||
(0.65–0.87)
|
(0.66–0.92)
| |||
Total bilirubin |
0.32
| |||
(0.16–0.68)
| ||||
AST |
0.97
| |||
(0.95–1.00)
| ||||
Creatinine |
1.67
| |||
(1.10–2.53)
|