Background
Methods
Synthesis of PLGA-coated Fe3O4microcapsules
Characterizing PLGA-coated Fe3O4microcapsules
MDA cell culture and PLGA-coated Fe3O4microcapsule uptake by MDA cells
MTT assay
Acute biosafety of PLGA-coated Fe3O4microcapsules
Animal model and experimental equipment
MR-guided HIFU surgery for rabbits bearing the VX2 liver tumor
Statistical analysis
Results and discussion
Characterization of PLGA-coated Fe3O4microcapsules
Uptake of PLGA-coated Fe3O4microcapsules by MDA cells
Acute biosafety of PLGA-coated Fe3O4microcapsules
Pre-injection | 1 d | 3 d | 7 d | |
---|---|---|---|---|
ALT (U/L) | 64.33 ± 18.34 | 56.67 ± 15.01 | 51.00 ± 13.89 | 54.00 ± 16.09 |
AST (U/L) | 41.33 ± 1.53 | 42.33 ± 2.52 | 40.67 ± 4.16 | 45.33 ± 2.08 |
TBIL (μmol/L) | 3.47 ± 0.40 | 3.53 ± 0.15 | 3.27 ± 0.12 | 3.20 ± 0.26 |
BUN (mmol/L) | 7.55 ± 0.38 | 8.42 ± 0.39 | 7.81 ± 0.77 | 7.50 ± 0.62 |
SCr (μmol/L) | 68.77 ± 7.60 | 73.70 ± 4.40 | 62.37 ± 4.10 | 75.30 ± 9.04 |
CK (U/L) | 3242.67 ± 71.14 | 3420.00 ± 172.50 | 3457.67 ± 132.50 | 3362.33 ± 116.11 |
LDH (U/L) | 839.67 ± 10.02 | 850.67 ± 19.86 | 834.00 ± 18.00 | 857.00 ± 12.77 |
Pre-injection | 1 d | 3 d | 7 d | |
---|---|---|---|---|
ALT (U/L) | 50.80 ± 14.23 | 57.17 ± 14.06 | 63.53 ± 17.35 | 53.70 ± 15.11 |
AST (U/L) | 43.33 ± 1.56 | 41.35 ± 2.46 | 41.63 ± 3.56 | 43.83 ± 2.15 |
TBIL (μmol/L) | 3.45 ± 0.39 | 3.54 ± 0.17 | 3.29 ± 0.14 | 3.21 ± 0.33 |
BUN (mmol/L) | 7.79 ± 0.67 | 8.45 ± 0.37 | 7.65 ± 0.48 | 7.66 ± 0.58 |
SCr (μmol/L) | 66.57 ± 6.70 | 72.73 ± 4.37 | 64.26 ± 4.11 | 74.80 ± 8.05 |
CK (U/L) | 3354.39 ± 96.61 | 3422.00 ± 112.53 | 3446.62 ± 122.30 | 3277.65 ± 69.40 |
LDH (U/L) | 841.67 ± 11.02 | 848.63 ± 17.83 | 823.14 ± 16.73 | 856.37 ± 13.42 |
Pre-injection | 1 d | 3 d | 7 d | |
---|---|---|---|---|
ALT (U/L) | 59.23 ± 13.77 | 56.15 ± 14.55 | 51.30 ± 13.87 | 61.23 ± 16.55 |
AST (U/L) | 42.88 ± 1.45 | 41.09 ± 1.65 | 41.64 ± 2.00 | 43.56 ± 3.15 |
TBIL (μmol/L) | 3.49 ± 0.38 | 3.48 ± 0.23 | 3.37 ± 0.34 | 3.23 ± 0.32 |
BUN (mmol/L) | 7.58 ± 0.32 | 8.44 ± 0.43 | 7.76 ± 0.53 | 7.59 ± 0.63 |
SCr (μmol/L) | 69.65 ± 5.74 | 71.88 ± 4.43 | 66.30 ± 5.31 | 75.79 ± 7.98 |
CK (U/L) | 3280.98 ± 66.33 | 3445.09 ± 98.71 | 3453.98 ± 112.27 | 3325.0 ± 111.20 |
LDH (U/L) | 853.34 ± 10.71 | 847.72 ± 15.30 | 838.99 ± 17.90 | 850.08 ± 16.98 |