Bas Groot Koerkamp and François E. J. A. Willemssen contributed equally to this work.
This study was presented as an mini-oral presentation at the International Hepato-Pancreato-Biliary Association World Congress, 4–7 September 2018, Geneva, Switzerland.
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The aim was to compare the prognostic accuracy of cross-sectional imaging of the 7th and 8th editions of the American Joint Committee on Cancer(AJCC) staging system for perihilar cholangiocarcinoma(PHC).
All patients with PHC between 2002 and 2014 were included. Imaging at the time of presentation was reassessed and clinical tumor–node–metastasis (cTNM) stage was determined according to the 7th and 8th editions of the AJCC staging system. Comparison of the prognostic accuracy was performed using the concordance index (c-index).
A total of 248 PHC patients were included;45 patients(18.1%) underwent a curative-intent resection, whereas 203 patients(81.9%) did not because they were unfit for surgery or were diagnosed with locally advanced or metastatic disease during workup. Prognostic accuracy was comparable between the 7th and 8th editions (c-index 0.57 vs 0.58). For patients who underwent a curative-intent resection, the prognostic accuracy of the 8th edition (0.67) was higher than the 7th (0.65). For patients who did not undergo a curative-intent resection, the prognostic accuracy was poor in both the 7th as the 8th editions (0.54 vs 0.57).
The 7th and 8th editions of the AJCC staging system for PHC have comparable prognostic accuracy. Prognostic accuracy was particularly poor in unresectable patients.
Jarnagin W, Winston C: Hilar cholangiocarcinoma: diagnosis and staging. HPB (Oxford) 2005;7:244–251. CrossRef
Jarnagin WR, Fong Y, DeMatteo RP, et al.: Staging, resectability, and outcome in 225 patients with hilar cholangiocarcinoma. Ann Surg 2001;234:507–517; discussion 517-509. CrossRef
Chaiteerakij R, Harmsen WS, Marrero CR, et al.: A new clinically based staging system for perihilar cholangiocarcinoma. Am J Gastroenterol 2014;109:1881–1890. CrossRef
Pichlmayr R, Lamesch P, Weimann A, et al.: Surgical treatment of cholangiocellular carcinoma. World J Surg 1995;19:83–88. CrossRef
Groot Koerkamp B, Wiggers JK, Gonen M, et al.: Survival after resection of perihilar cholangiocarcinoma-development and external validation of a prognostic nomogram. Ann Oncol 2015;26:1930–1935. CrossRef
Ruys AT, van Haelst S, Busch OR, et al.: Long-term survival in hilar cholangiocarcinoma also possible in unresectable patients. World J Surg 2012;36:2179–2186. CrossRef
Shen W, Punyanitya M, Wang Z, et al.: Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image. J Appl Physiol (1985) 2004; 97:2333–2338.
Edge SB BD, Compton CC, Fritz AG, Greene FL, Trotti A, editors.: AJCC cancer staging manual (7th ed). New York, NY: Springer; 2010.
van Vugt JLA, Gaspersz MP, Coelen RJS, et al.: The prognostic value of portal vein and hepatic artery involvement in patients with perihilar cholangiocarcinoma. HPB (Oxford) 2017.
Coelen RJS, Gaspersz MP, Labeur TA, et al.: Validation of the Mayo Clinic Staging System in Determining Prognoses of Patients With Perihilar Cholangiocarcinoma. Clin Gastroenterol Hepatol 2017;15:1930–1939 e1933. CrossRef
Edge SB, Compton CC: The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 2010;17:1471–1474. CrossRef
Groot Koerkamp B, Wiggers JK, Allen PJ, et al.: American Joint Committee on Cancer staging for resected perihilar cholangiocarcinoma: a comparison of the 6th and 7th editions. HPB (Oxford) 2014;16:1074–1082. CrossRef
Ebata T, Kosuge T, Hirano S, et al.: Proposal to modify the International Union Against Cancer staging system for perihilar cholangiocarcinomas. Br J Surg 2014;101:79–88. CrossRef
Juntermanns B, Sotiropoulos GC, Radunz S, et al.: Comparison of the sixth and the seventh editions of the UICC classification for perihilar cholangiocarcinoma. Ann Surg Oncol 2013;20:277–284. CrossRef
- Evaluation of the New American Joint Committee on Cancer Staging Manual 8th Edition for Perihilar Cholangiocarcinoma
Marcia P. Gaspersz
Jeroen L. A. van Vugt
Jeroen de Jonge
Wojciech G. Polak
Jan N. M. Ijzermans
Bas Groot Koerkamp
François E. J. A. Willemssen
- Springer US
Journal of Gastrointestinal Surgery
Print ISSN: 1091-255X
Elektronische ISSN: 1873-4626
Neu im Fachgebiet Chirurgie
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