nach oben

Archives of Gynecology and Obstetrics

Erschienen in:

01.09.2011 | Materno-fetal Medicine

Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran

verfasst von: Mojgan Mokhtari, Mohammad Hashemi, Minoo Yaghmaei, Mohammad Naderi, Abdolsamad Shikhzadeh, Saeid Ghavami

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2011

Einloggen, um Zugang zu erhalten

Abstract

Purpose

There is conflicting data regarding leptin in gestational diabetes mellitus (GDM). The aim of the present study was to compare serum leptin levels between individuals with GDM and normal pregnancy.

Methods

This case–control study was performed on 26 GDM and 22 healthy pregnant women. Leptin concentrations were measured using an enzyme immunoassay.

Results

The level of serum leptin was not significantly different between GDM (9.890 ± 7.764 ng/ml) and normal pregnant women (13.80 ± 10.32 ng/ml) (p = 0.14).

Conclusion

There are no significant differences between GDM and normal pregnant women regarding leptin levels.

Catalano PM, Tyzbir ED, Roman NM, Amini SB, Sims EA (1991) Longitudinal changes in insulin release and insulin resistance in non-obese pregnant women. Am J Obstet Gynecol 165:1667–1672PubMed

Ryan EA, Enns L (1988) Role of gestational hormones in the induction of insulin resistance. J Clin Endocrinol Metab 67:341–347PubMedCrossRef

Henson MC, Castracane VD (2006) Leptin in pregnancy: an update. Biol Reprod 74:218–229PubMedCrossRef

Kautzky-Willer A, Pacini G, Tura A, Bieglmayer C, Schneider B, Ludvik B, Prager R, Waldhausl W (2001) Increased plasma leptin in gestational diabetes. Diabetologia 44:164–172PubMedCrossRef

Gao XL, Yang HX, Zhao Y (2008) Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus. Chin Med J (Engl) 121:701–705

McLachlan KA, O’Neal D, Jenkins A, Alford FP (2006) Do adiponectin, TNFalpha, leptin and CRP relate to insulin resistance in pregnancy? studies in women with and without gestational diabetes, during and after pregnancy. Diabetes Metab Res Rev 22:131–138PubMedCrossRef

Festa A, Shnawa N, Krugluger W, Hopmeier P, Schernthaner G, Haffner SM (1999) Relative hypoleptinaemia in women with mild gestational diabetes mellitus. Diabet Med 16:656–662PubMedCrossRef

Simmons D, Breier BH (2002) Fetal overnutrition in polynesian pregnancies and in gestational diabetes may lead to dysregulation of the adipoinsular axis in offspring. Diabetes Care 25:1539–1544PubMedCrossRef

Mokhtari M, Hashemi M, Yaghmaei M, Molashahi F, Shikhzadeh A, Niazi A, Ghavami S (2010) Serum adenosine deaminase activity in gestational diabetes mellitus and normal pregnancy. Arch Gynecol Obstet 281:623–626PubMedCrossRef

10.

Yaghmaei M, Hashemi M, Shikhzadeh A, Mokhtari M, Niazi A, Ghavami S (2009) Serum trypsin inhibitory capacity in normal pregnancy and gestational diabetes mellitus. Diabetes Res Clin Pract 84:201–204PubMedCrossRef

11.

Yilmaz O, Kucuk M, Ilgin A, Dagdelen M (2010) Assessment of insulin sensitivity/resistance and their relations with leptin concentrations and anthropometric measures in a pregnant population with and without gestational diabetes mellitus. J Diabetes Complications 24:109–114PubMedCrossRef

12.

Cseh K, Baranyi E, Melczer Z, Csakany GM, Speer G, Kovacs M, Gero G, Karadi I, Winkler G (2002) The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. Gynecol Endocrinol 16:453–460PubMed

13.

Sivan E, Whittaker PG, Sinha D, Homko CJ, Lin M, Reece EA, Boden G (1998) Leptin in human pregnancy: the relationship with gestational hormones. Am J Obstet Gynecol 179:1128–1132PubMedCrossRef

14.

Stock SM, Bremme KA (1998) Elevation of plasma leptin levels during pregnancy in normal and diabetic women. Metabolism 47:840–843PubMedCrossRef

15.

Garcia-Arencibia M, Molero S, Davila N, Carranza MC, Calle C (2005) 17beta-Estradiol transcriptionally represses human insulin receptor gene expression causing cellular insulin resistance. Leuk Res 29:79–87PubMedCrossRef

16.

Collison M, Campbell IW, Salt IP, Dominiczak AF, Connell JM, Lyall H, Gould GW (2000) Sex hormones induce insulin resistance in 3T3–L1 adipocytes by reducing cellular content of IRS proteins. Diabetologia 43:1374–1380PubMedCrossRef

17.

Buren J, Liu HX, Jensen J, Eriksson JW (2002) Dexamethasone impairs insulin signalling and glucose transport by depletion of insulin receptor substrate-1, phosphatidylinositol 3-kinase and protein kinase B in primary cultured rat adipocytes. Eur J Endocrinol 146:419–429PubMedCrossRef

18.

Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425–432PubMedCrossRef

19.

Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM (1997) Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 94:8878–8883PubMedCrossRef

20.

Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546–549PubMedCrossRef

21.

Schwartz MW, Baskin DG, Bukowski TR, Kuijper JL, Foster D, Lasser G, Prunkard DE, Porte D Jr, Woods SC, Seeley RJ, Weigle DS (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45:531–535PubMedCrossRef

22.

Banerji MA, Faridi N, Atluri R, Chaiken RL, Lebovitz HE (1999) Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men. J Clin Endocrinol Metab 84:137–144PubMedCrossRef

23.

Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE (2002) The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes 51:1005–1015PubMedCrossRef

24.

Fernandez-Real JM, Gutierrez C, Ricart W, Casamitjana R, Fernandez-Castaner M, Vendrell J, Richart C, Soler J (1997) The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance, percent body fat, and increased serum leptin levels. Diabetes 46:1468–1472PubMedCrossRef

25.

Henson MC, Castracane VD (2000) Leptin in pregnancy. Biol Reprod 63:1219–1228PubMedCrossRef

26.

Henson MC, Castracane VD (2002) Leptin: roles and regulation in primate pregnancy. Semin Reprod Med 20:113–122PubMedCrossRef

27.

Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, Nakao K (1997) Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3:1029–1033PubMedCrossRef

28.

Toth B, Fischl A, Scholz C, Kuhn C, Friese K, Karamouti M, Makrigiannakis A, Jeschke U (2009) Insulin and leptin receptors as possible new candidates for endocrine control in normal and disturbed human pregnancy. Mol Hum Reprod 15:231–239PubMedCrossRef

29.

Adali E, Yildizhan R, Kolusari A, Kurdoglu M, Bugdayci G, Sahin HG, Kamaci M (2009) Increased visfatin and leptin in pregnancies complicated by pre-eclampsia. J Matern Fetal Neonatal Med 1:1–7

30.

Lewandowski K, Randeva HS, O’Callaghan CJ, Horn R, Medley GF, Hillhouse EW, Brabant G, O’Hare P (2001) Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin. Clin Endocrinol (Oxf) 54:533–539CrossRef

31.

Kleiblova P, Dostalova I, Bartlova M, Lacinova Z, Ticha I, Krejci V, Springer D, Kleibl Z, Haluzik M (2010) Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. Mol Cell Endocrinol 314:150–156PubMedCrossRef

Titel: Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran
verfasst von: Mojgan Mokhtari
Mohammad Hashemi
Minoo Yaghmaei
Mohammad Naderi
Abdolsamad Shikhzadeh
Saeid Ghavami
Publikationsdatum: 01.09.2011
Verlag: Springer-Verlag
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2011
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-010-1681-0

Neu im Fachgebiet Gynäkologie und Geburtshilfe

Antikörper-Wirkstoff-Konjugat hält solide Tumoren in Schach

16.05.2024 Zielgerichtete Therapie Nachrichten

Trastuzumab deruxtecan scheint auch jenseits von Lungenkrebs gut gegen solide Tumoren mit HER2-Mutationen zu wirken. Dafür sprechen die Daten einer offenen Pan-Tumor-Studie.

Mammakarzinom: Senken Statine das krebsbedingte Sterberisiko?

15.05.2024 Mammakarzinom Nachrichten

Frauen mit lokalem oder metastasiertem Brustkrebs, die Statine einnehmen, haben eine niedrigere krebsspezifische Mortalität als Patientinnen, die dies nicht tun, legen neue Daten aus den USA nahe.

S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Gestationsdiabetes: In der zweiten Schwangerschaft folgenreicher als in der ersten

13.05.2024 Gestationsdiabetes Nachrichten

Das Risiko, nach einem Gestationsdiabetes einen Typ-2-Diabetes zu entwickeln, hängt nicht nur von der Zahl, sondern auch von der Reihenfolge der betroffenen Schwangerschaften ab.

Update Gynäkologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen

Die Highlights vom Kongress des American College of Cardiology 2024

Springer Medizin

Evaluation of the serum leptin in normal pregnancy and gestational diabetes mellitus in Zahedan, southeast Iran