Evaluation of the Sysmex XT-2000iV haematology analyser for rat, dog and mouse whole blood samples

The Sysmex XT-2000iV is a dedicated haematology analyser with full blood count, reticulocyte and five-population differential leucocyte capabilities for several laboratory animal species. The laboratory animal species chosen for this study were rat, dog and mouse. Results from dipotassium ethylenediamine tetraacetic acid (K₂EDTA) samples from these species were compared with the laboratory’s established haematology analyser, the Bayer (now Siemens) Advia 120™ with multispecies software (Siemens Medical Solutions Diagnostics Europe Limited, Frimley, UK). Imprecision, carry-over between samples, linearity and stability data were also studied. In addition, results obtained for leucocyte differential counts were compared with standard manual 100-cell counts. Throughout this study, the Sysmex XT-2000iV proved to be robust, reliable and dependable. In summary, the Sysmex XT-2000iV has proved capable of accurately and precisely producing haematology results for animal species used within the pharmaceutical industry.