Erschienen in:
10.03.2018 | Original Article
Evaluation of work disability in Japanese patients with rheumatoid arthritis: from the TOMORROW study
verfasst von:
Shohei Anno, Yuko Sugioka, Kentaro Inui, Masahiro Tada, Tadashi Okano, Kenji Mamoto, Tatsuya Koike
Erschienen in:
Clinical Rheumatology
|
Ausgabe 7/2018
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Abstract
To evaluate work disability and associated factors in patients with rheumatoid arthritis (RA) who participated in the TOMORROW study, a 10-year cohort study in Japan. Subjects in this cross-sectional analysis comprised 191 RA patients and 191 age- and sex-matched non-RA individuals. Work-related outcomes were measured using the Work Productivity and Activity Impairment questionnaire by employment status (full-time worker (FTW), employed ≥ 35 h/week; part-time worker (PTW), < 35 h/week; home worker (HW), non-employed). In addition, we assessed the EuroQol-5 Dimensions (EQ-5D) and Health Assessment Questionnaire (HAQ) to evaluate quality of life and activities of daily living. No significant differences were evident between groups in percentages of participants in each employment status (
p = 0.11), percentages of absenteeism (FTW,
p = 1.00; PTW,
p = 0.29), presenteeism (FTW,
p = 0.23; PTW,
p = 0.54), overall work impairment (FTW,
p = 0.23; PTW,
p = 0.73), or percentage of activity impairment (AI) (FTW,
p = 0.62; PTW,
p = 0.60). In the HW group, percentage of AI was higher in RA patients than that in non-RA patients (
p < 0.01). Among RA patients, HW showed lower EQ-5D and higher HAQ than FTW or PTW (
p < 0.001 each). Higher disease activity was observed in HW than FTW (
p < 0.01). In terms of the effect of biological disease-modifying anti-rheumatic drugs, no significant differences in work-related outcomes, health status, or daily activity were evident between users and non-users. No significant differences in employment status or work impairment were seen between RA and non-RA groups among paid workers. HW with RA showed more impaired daily activity and higher disease activity compared to working RA patients. Trial registration: University Hospital Medical Information Network Clinical Trials Registry:
UMIN000003876. Registered 1 Jun 2010.