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Sleep and Breathing
Erschienen in: Sleep and Breathing 2/2020

23.08.2019 | Sleep Breathing Physiology and Disorders • Review

Excessive daytime sleepiness and fatigue in neurological disorders

verfasst von: Michelangelo Maestri, Andrea Romigi, Alessandro Schirru, Monica Fabbrini, Sara Gori, Ubaldo Bonuccelli, Enrica Bonanni

Erschienen in: Sleep and Breathing | Ausgabe 2/2020

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Abstract

Excessive daytime sleepiness (EDS) and fatigue are some of the most frequent symptoms in neurological diseases and could impact on quality of life by increasing the risk of accidents and generally affecting daily life activities. In this review, we will examine the variety of causes responsible for EDS in neurological diseases, including nocturnal sleep alterations, CNS pathological abnormalities with alterations in arousal and/or REM regulation systems, circadian rhythms disorders, drugs, and comorbid psychiatric or primary sleep disorders. Among neurological diseases, epilepsy, dementia, Parkinson disease, multiple sclerosis, and myotonic dystrophies represented a model for these interactions between EDS and neurological diseases. A complete diagnostic workup in neurological patients with EDS should be undertaken since EDS can worsen many different aspects such as psychiatric symptoms, cognitive deficit, and in some cases, the severity of the neurological disease per se. Moreover, quality of life and risk of accidents are dependent on EDS. An individualized approach to this symptom in neurological patients should be considered with a focus on modifiable causes such as SDB, psychiatric comorbidities, and drugs. When considering EDS and fatigue in neurological diseases, close attention to lifestyle and sleep hygiene is advisable. A critical review of ongoing pharmacological therapy should not be overlooked. Possible diagnosis and treatment of SDB should be always considered.
Literatur
1.
American Academy of Sleep Medicine (2014) In: Darien IL (ed) The International Classification of Sleep Disorders – Third Edition (ICSD-3), 3rd edn. American Academy of Sleep Medicine, Darien
2.
Mills RJ, Young CA (2008) A medical definition of fatigue in multiple sclerosis. QJM. 101(1):49–60CrossRefPubMed
3.
4.
5.
Happe S (2003) Excessive daytime sleepiness and sleep disturbances in patients with neurological diseases: epidemiology and management. Drugs. 63(24):2725–2737CrossRefPubMed
6.
Guilleminault C, Brooks SN (2001) Excessive daytime sleepiness: a challenge for the practising neurologist. Brain. 124(Pt 8):1482–1491CrossRefPubMed
7.
Bonanni E, Maestri M, Coscio ED, Murri L (2012) Excessive daytime sleepiness in neurological disorders. In: Silvestri R (ed) Sleep Disorders in Neurology. Nova Science Publishers, Hauppauge, pp 59–69
8.
Cluydts R, De Valck E, Verstraeten E, Theys P (2002) Daytime sleepiness and its evaluation. Sleep Med Rev 6(2):83–96CrossRefPubMed
9.
Shen J, Barbera J, Shapiro CM (2006) Distinguishing sleepiness and fatigue: focus on definition and measurement. Sleep Med Rev 10(1):63–76CrossRefPubMed
10.
Hirshkowitz M, Sharafkhaneh A (2017) Evaluating sleepiness. In: Principles and practice of sleep medicine. Elsevier, pp 1651–1658.e3
11.
Gigli GL, Placidi F, Diomedi M, Maschio M, Silvestri G, Scalise A et al (1997) Nocturnal sleep and daytime somnolence in untreated patients with temporal lobe epilepsy: changes after treatment with controlled-release carbamazepine. Epilepsia. 38(6):696–701CrossRefPubMed
12.
Bonanni E, Galli R, Maestri M, Pizzanelli C, Fabbrini M, Manca ML, Iudice A, Murri L (2004) Daytime sleepiness in epilepsy patients receiving topiramate monotherapy. Epilepsia. 45(4):333–337CrossRefPubMed
13.
Maestri M, Giorgi FS, Pizzanelli C, Fabbrini M, Di Coscio E, Carnicelli L et al (2013) Daytime sleepiness in de novo untreated patients with epilepsy. Epilepsy Behav 29(2):344–348CrossRefPubMed
14.
de Weerd A, de Haas S, Otte A, Trenité DK-N, van Erp G, Cohen A et al (2004) Subjective sleep disturbance in patients with partial epilepsy: a questionnaire-based study on prevalence and impact on quality of life. Epilepsia. 45(11):1397–1404CrossRefPubMed
15.
Pizzatto R, Lin K, Watanabe N, Campiolo G, Bicalho MAH, Guarnieri R et al (2013) Excessive sleepiness and sleep patterns in patients with epilepsy: a case-control study. Epilepsy Behav 29(1):63–66CrossRefPubMed
16.
Shen Y, Zhang M, Wang Y, Wang L, Xu X, Xiao G et al (2017) Subjective sleep disturbance in Chinese adults with epilepsy: associations with affective symptoms. Epilepsy Res 135:150–157CrossRefPubMed
17.
Khatami R, Zutter D, Siegel A, Mathis J, Donati F, Bassetti CL (2006) Sleep-wake habits and disorders in a series of 100 adult epilepsy patients--a prospective study. Seizure. 15(5):299–306CrossRefPubMed
18.
Vignatelli L, Bisulli F, Naldi I, Ferioli S, Pittau F, Provini F et al (2006) Excessive daytime sleepiness and subjective sleep quality in patients with nocturnal frontal lobe epilepsy: a case-control study. Epilepsia. 47(Suppl 5):73–77CrossRefPubMed
19.
Im H-J, Park S-H, Baek S-H, Chu MK, Yang KI, Kim W-J et al (2016) Associations of impaired sleep quality, insomnia, and sleepiness with epilepsy: a questionnaire-based case-control study. Epilepsy Behav 57(Pt A):55–59CrossRefPubMed
20.
Ismayilova V, Demir AU, Tezer FI (2015) Subjective sleep disturbance in epilepsy patients at an outpatient clinic: a questionnaire-based study on prevalence. Epilepsy Res 115:119–125CrossRefPubMed
21.
Yazdi Z, Sadeghniiat-Haghighi K, Naimian S, Zohal MA, Ghaniri M (2013) Prevalence of sleep disorders and their effects on sleep quality in epileptic patients. Basic Clin Neurosci 4(1):36–41PubMedPubMedCentral
22.
Gammino M, Zummo L, Bue AL, Urso L, Terruso V, Marrone O et al (2016) Excessive daytime sleepiness and sleep disorders in a population of patients with epilepsy: a case-control study. J Epilepsy Res 6(2):79–86CrossRefPubMed
23.
Moser D, Pablik E, Aull-Watschinger S, Pataraia E, Wöber C, Seidel S (2015) Depressive symptoms predict the quality of sleep in patients with partial epilepsy--a combined retrospective and prospective study. Epilepsy Behav 47:104–110CrossRefPubMed
24.
Roshan S, Puri V, Chaudhry N, Gupta A, Rabi SK (2017) Sleep abnormalities in juvenile myoclonic epilepsy-a sleep questionnaire and polysomnography based study. Seizure. 50:194–201CrossRefPubMed
25.
Saraswati N, Nayak C, Sinha S, Nagappa M, Thennarasu K, Taly AB (2017) Comparing sleep profiles between patients with juvenile myoclonic epilepsy and symptomatic partial epilepsy: sleep questionnaire-based study. Epilepsy Behav 66:34–38CrossRefPubMed
26.
Ramachandraiah CT, Sinha S, Taly AB, Rao S, Satishchandra P (2012) Interrelationship of sleep and juvenile myoclonic epilepsy (JME): a sleep questionnaire-, EEG-, and polysomnography (PSG)-based prospective case-control study. Epilepsy Behav 25(3):391–396CrossRefPubMed
27.
Manni R, Politini L, Sartori I, Ratti MT, Galimberti CA, Tartara A (2000) Daytime sleepiness in epilepsy patients: evaluation by means of the Epworth Sleepiness Scale. J Neurol 247(9):716–717CrossRefPubMed
28.
Krishnan P, Sinha S, Taly AB, Ramachandraiah CT, Rao S, Satishchandra P (2012) Sleep disturbances in juvenile myoclonic epilepsy: a sleep questionnaire-based study. Epilepsy Behav 23(3):305–309CrossRefPubMed
29.
Klobucníková K, Kollár B, Martinisková Z (2009) Daytime sleepiness and changes of sleep architecture in patients with epilepsy. Neuro Endocrinol Lett 30(5):599–603PubMed
30.
Manni R, Tartara A (2000) Evaluation of sleepiness in epilepsy. Clin Neurophysiol 111(Suppl 2):S111–S114CrossRefPubMed
31.
Foldvary-Schaefer N, Grigg-Damberger M (2009) Sleep and epilepsy. Semin Neurol 29(4):419–428CrossRefPubMed
32.
van Golde EGA, Gutter T, de Weerd AW (2011) Sleep disturbances in people with epilepsy; prevalence, impact and treatment. Sleep Med Rev 15(6):357–368CrossRefPubMed
33.
Crespel A, Coubes P, Baldy-Moulinier M (2000) Sleep influence on seizures and epilepsy effects on sleep in partial frontal and temporal lobe epilepsies. Clin Neurophysiol 111(Suppl 2):S54–S59CrossRefPubMed
34.
Bazil CW, Castro LH, Walczak TS (2000) Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy. Arch Neurol 57(3):363–368CrossRefPubMed
35.
Sudbrack-Oliveira P, Lima Najar L, Foldvary-Schaefer N, da Mota Gomes M (2019) Sleep architecture in adults with epilepsy: a systematic review. Sleep Med 53:22–27CrossRefPubMed
36.
Crespel A, Baldy-Moulinier M, Coubes P (1998) The relationship between sleep and epilepsy in frontal and temporal lobe epilepsies: practical and physiopathologic considerations. Epilepsia. 39(2):150–157CrossRefPubMed
37.
Zucconi M, Oldani A, Smirne S, Ferini-Strambi L (2000) The macrostructure and microstructure of sleep in patients with autosomal dominant nocturnal frontal lobe epilepsy. J Clin Neurophysiol 17(1):77–86CrossRefPubMed
38.
Parrino L, Halasz P, Tassinari CA, Terzano MG (2006) CAP, epilepsy and motor events during sleep: the unifying role of arousal. Sleep Med Rev 10(4):267–285CrossRefPubMed
39.
Beghi E, Mascio RD, Sasanelli F (1986) Adverse reactions to antiepileptic drugs: a multicenter survey of clinical practice. Epilepsia. 27(4):323–330CrossRef
40.
Jain SV, Glauser TA (2014) Effects of epilepsy treatments on sleep architecture and daytime sleepiness: an evidence-based review of objective sleep metrics. Epilepsia. 55(1):26–37CrossRefPubMed
41.
Zaccara G, Gangemi PF, Cincotta M (2008) Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies. Seizure. 17(5):405–421CrossRefPubMed
42.
Sivathamboo S, Farrand S, Chen Z, White EJ, Pattichis AA, Hollis C et al (2019) Sleep-disordered breathing among patients admitted for inpatient video-EEG monitoring. Neurology. 92(3):e194–e204CrossRefPubMed
43.
Foldvary-Schaefer N, Andrews ND, Pornsriniyom D, Moul DE, Sun Z, Bena J (2012) Sleep apnea and epilepsy: who’s at risk? Epilepsy Behav 25(3):363–367CrossRefPubMed
44.
Manni R, Terzaghi M, Arbasino C, Sartori I, Galimberti CA, Tartara A (2003) Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and features of the comorbidity. Epilepsia. 44(6):836–840CrossRefPubMed
45.
Malow BA, Levy K, Maturen K, Bowes R (2000) Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology. 55(7):1002–1007CrossRefPubMed
46.
Gori S, Lucchesi C, Maluccio MR, Morelli N, Maestri M, Bonanni E et al (2012) Inter-critical and critical excessive daily sleepiness in episodic migraine patients. Neurol Sci 33(5):1133–1136CrossRefPubMed
47.
Karsan N, Bose P, Goadsby PJ (2018) The migraine premonitory phase. Continuum (Minneap, Minn) 24(4, Headache):996–1008
48.
Barbanti P, Fabbrini G, Aurilia C, Vanacore N, Cruccu G (2007) A case-control study on excessive daytime sleepiness in episodic migraine. Cephalalgia. 27(10):1115–1119CrossRefPubMed
49.
Seidel S, Hartl T, Weber M, Matterey S, Paul A, Riederer F et al (2009) Quality of sleep, fatigue and daytime sleepiness in migraine - a controlled study. Cephalalgia. 29(6):662–669CrossRefPubMed
50.
Gori S, Lucchesi C, Baldacci F, Bonuccelli U (2015) Preferential occurrence of attacks during night sleep and/or upon awakening negatively affects migraine clinical presentation. Funct Neurol 30(2):119–123PubMedPubMedCentral
51.
Stavem K, Kristiansen HA, Kristoffersen ES, Kværner KJ, Russell MB (2017) Association of excessive daytime sleepiness with migraine and headache frequency in the general population. J Headache Pain 18(1):35CrossRefPubMedPubMedCentral
52.
Kristoffersen ES, Stavem K, Lundqvist C, Russell MB (2018) Excessive daytime sleepiness in chronic migraine and chronic tension-type headache from the general population. Cephalalgia. 38(5):993–997CrossRefPubMed
53.
Kim J, Cho S-J, Kim W-J, Yang KI, Yun C-H, Chu MK (2016) Excessive daytime sleepiness is associated with an exacerbation of migraine: a population-based study. J Headache Pain. 17(1):62CrossRefPubMedPubMedCentral
54.
Peres MFP, Zukerman E, Young WB, Silberstein SD (2002) Fatigue in chronic migraine patients. Cephalalgia. 22(9):720–724CrossRefPubMed
55.
Lucchesi C, Sassi AN, Siciliano G, Gori S (2013) Fatigue is increased in episodic migraine without aura patients. Headache. 53(7):1163–1165CrossRefPubMed
56.
Stronks DL, Tulen JHM, Bussmann JBJ, Mulder LJMM, Passchier J (2004) Interictal daily functioning in migraine. Cephalalgia. 24(4):271–279CrossRefPubMed
57.
Seo J-G, Park S-P (2018) Significance of fatigue in patients with migraine. J Clin Neurosci 50:69–73CrossRefPubMed
58.
Lucchesi C, Baldacci F, Cafalli M, Dini E, Giampietri L, Siciliano G et al (2016) Fatigue, sleep-wake pattern, depressive and anxiety symptoms and body-mass index: analysis in a sample of episodic and chronic migraine patients. Neurol Sci 37(6):987–989CrossRefPubMed
59.
Baldacci F, Cafalli M, Lucchesi C, Mazzucchi S, Dini E, Bonuccelli U et al (2015) P058. Refractory chronic migraine, fatigue and OnabotulinumtoxinA: a clinic setting experience. J Headache Pain 16(Suppl 1):A113CrossRefPubMedPubMedCentral
60.
Bliwise DL (2004) Sleep disorders in Alzheimer’s disease and other dementias. Clin Cornerstone 6(Suppl 1A):S16–S28CrossRefPubMed
61.
Bonanni E, Maestri M, Tognoni G, Fabbrini M, Nucciarone B, Manca ML et al (2005) Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment. J Sleep Res 14(3):311–317CrossRefPubMed
62.
Vitiello MV, Bliwise DL, Prinz PN (1992) Sleep in Alzheimer’s disease and the sundown syndrome. Neurology. 42(7 Suppl 6):83–93 discussion 93PubMed
63.
Montplaisir J, Petit D, Lorrain D, Gauthier S, Nielsen T (1995) Sleep in Alzheimer’s disease: further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms. Sleep. 18(3):145–148CrossRefPubMed
64.
Guarnieri B, Adorni F, Musicco M, Appollonio I, Bonanni E, Caffarra P et al (2012) Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord 33(1):50–58CrossRefPubMedPubMedCentral
65.
Steriade M (1996) Arousal: revisiting the reticular activating system. Science. 272(5259):225–226CrossRefPubMed
66.
Liguori C, Romigi A, Nuccetelli M, Zannino S, Sancesario G, Martorana A et al (2014) Orexinergic system dysregulation, sleep impairment, and cognitive decline in Alzheimer disease. JAMA Neurol. 71(12):1498–1505CrossRefPubMed
67.
68.
Mander BA, Winer JR, Jagust WJ, Walker MP (2016) Sleep: a novel mechanistic pathway, biomarker, and treatment target in the pathology of Alzheimer’s disease? Trends Neurosci 39(8):552–566CrossRefPubMedPubMedCentral
69.
Kang J-E, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR et al (2009) Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. 326(5955):1005–1007CrossRefPubMedPubMedCentral
70.
Roh JH, Huang Y, Bero AW, Kasten T, Stewart FR, Bateman RJ et al (2012) Disruption of the sleep-wake cycle and diurnal fluctuation of β-amyloid in mice with Alzheimer’s disease pathology. Sci Transl Med 4(150):150ra122CrossRefPubMedPubMedCentral
71.
Tranah GJ, Blackwell T, Stone KL, Ancoli-Israel S, Paudel ML, Ensrud KE et al (2011) Circadian activity rhythms and risk of incident dementia and mild cognitive impairment in older women. Ann Neurol 70(5):722–732CrossRefPubMedPubMedCentral
72.
Lim ASP, Kowgier M, Yu L, Buchman AS, Bennett DA (2013) Sleep fragmentation and the risk of incident Alzheimer’s disease and cognitive decline in older persons. Sleep. 36(7):1027–1032CrossRefPubMedPubMedCentral
73.
Lim ASP, Ellison BA, Wang JL, Yu L, Schneider JA, Buchman AS et al (2014) Sleep is related to neuron numbers in the ventrolateral preoptic/intermediate nucleus in older adults with and without Alzheimer’s disease. Brain. 137(Pt 10):2847–2861CrossRefPubMedPubMedCentral
74.
Ju Y-ES, McLeland JS, Toedebusch CD, Xiong C, Fagan AM, Duntley SP et al (2013) Sleep quality and preclinical Alzheimer disease. JAMA Neurol 70(5):587–593CrossRefPubMedPubMedCentral
75.
Yaffe K, Laffan AM, Harrison SL, Redline S, Spira AP, Ensrud KE et al (2011) Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 306(6):613–619CrossRefPubMedPubMedCentral
76.
Osorio RS, Gumb T, Pirraglia E, Varga AW, Lu S-E, Lim J et al (2015) Sleep-disordered breathing advances cognitive decline in the elderly. Neurology. 84(19):1964–1971CrossRefPubMedPubMedCentral
77.
Gosselin N, Baril A-A, Osorio RS, Kaminska M, Carrier J (2019) Obstructive sleep apnea and the risk of cognitive decline in older adults. Am J Respir Crit Care Med 199(2):142–148CrossRefPubMedPubMedCentral
78.
Troussière A-C, Charley CM, Salleron J, Richard F, Delbeuck X, Derambure P et al (2014) Treatment of sleep apnoea syndrome decreases cognitive decline in patients with Alzheimer’s disease. J Neurol Neurosurg Psychiatry 85(12):1405–1408CrossRefPubMed
79.
Cooke JR, Ayalon L, Palmer BW, Loredo JS, Corey-Bloom J, Natarajan L et al (2009) Sustained use of CPAP slows deterioration of cognition, sleep, and mood in patients with Alzheimer’s disease and obstructive sleep apnea: a preliminary study. J Clin Sleep Med 5(4):305–309CrossRefPubMedPubMedCentral
80.
Guarnieri B, Musicco M, Caffarra P, Adorni F, Appollonio I, Arnaldi D et al (2014) Recommendations of the Sleep Study Group of the Italian Dementia Research Association (SINDem) on clinical assessment and management of sleep disorders in individuals with mild cognitive impairment and dementia: a clinical review. Neurol Sci 35(9):1329–1348CrossRefPubMed
81.
Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP et al (2009) The PRIAMO study: a multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord 24(11):1641–1649CrossRefPubMed
82.
Loddo G, Calandra-Buonaura G, Sambati L, Giannini G, Cecere A, Cortelli P et al (2017) The treatment of sleep disorders in Parkinson’s disease: from research to clinical practice. Front Neurol 8:42CrossRefPubMedPubMedCentral
83.
Arnulf I, Konofal E, Merino-Andreu M, Houeto JL, Mesnage V, Welter ML et al (2002) Parkinson’s disease and sleepiness: an integral part of PD. Neurology. 58(7):1019–1024CrossRefPubMed
84.
85.
Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP (2006) Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology. 67(5):853–858CrossRefPubMed
86.
Frucht S, Rogers JD, Greene PE, Gordon MF, Fahn S (1999) Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology. 52(9):1908–1910CrossRefPubMed
87.
De Cock VC, Vidailhet M, Arnulf I (2008) Sleep disturbances in patients with parkinsonism. Nat Clin Pract Neurol 4(5):254–266CrossRefPubMed
88.
Cochen De Cock V, Abouda M, Leu S, Oudiette D, Roze E, Vidailhet M et al (2010) Is obstructive sleep apnea a problem in Parkinson’s disease? Sleep Med 11(3):247–252CrossRefPubMed
89.
Bliwise DL, Trotti LM, Juncos JJ, Factor SA, Freeman A, Rye DB (2013) Daytime REM sleep in Parkinson’s disease. Parkinsonism Relat Disord 19(1):101–103CrossRefPubMed
90.
Fronczek R, Overeem S, Lee SYY, Hegeman IM, van Pelt J, van Duinen SG et al (2007) Hypocretin (orexin) loss in Parkinson’s disease. Brain. 130(Pt 6):1577–1585CrossRefPubMed
91.
Thannickal TC, Lai Y-Y, Siegel JM (2007) Hypocretin (orexin) cell loss in Parkinson’s disease. Brain. 130(Pt 6):1586–1595CrossRefPubMed
92.
Wen M-C, Ng SYE, Heng HSE, Chao YX, Chan LL, Tan EK et al (2016) Neural substrates of excessive daytime sleepiness in early drug naïve Parkinson’s disease: a resting state functional MRI study. Parkinsonism Relat Disord 24:63–68CrossRefPubMed
93.
Yousaf T, Pagano G, Niccolini F, Politis M (2018) Excessive daytime sleepiness may be associated with caudate denervation in Parkinson disease. J Neurol Sci 387:220–227CrossRefPubMed
94.
Paus S, Brecht HM, Köster J, Seeger G, Klockgether T, Wüllner U (2003) Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson’s disease. Mov Disord 18(6):659–667CrossRefPubMed
95.
Chung S, Bohnen NI, Albin RL, Frey KA, Müller MLTM, Chervin RD (2013) Insomnia and sleepiness in Parkinson disease: associations with symptoms and comorbidities. J Clin Sleep Med 9(11):1131–1137CrossRefPubMedPubMedCentral
96.
Avorn J, Schneeweiss S, Sudarsky LR, Benner J, Kiyota Y, Levin R et al (2005) Sudden uncontrollable somnolence and medication use in Parkinson disease. Arch Neurol 62(8):1242–1248CrossRefPubMed
97.
Ondo WG, Dat Vuong K, Khan H, Atassi F, Kwak C, Jankovic J (2001) Daytime sleepiness and other sleep disorders in Parkinson’s disease. Neurology. 57(8):1392–1396CrossRefPubMed
98.
Chahine LM, Amara AW, Videnovic A (2017) A systematic review of the literature on disorders of sleep and wakefulness in Parkinson’s disease from 2005 to 2015. Sleep Med Rev 35:33–50CrossRefPubMed
99.
Stefansdottir S, Gjerstad MD, Tysnes OB, Larsen JP (2012) Subjective sleep problems in patients with early Parkinson’s disease. Eur J Neurol 19(12):1575–1581CrossRefPubMed
100.
Shpirer I, Miniovitz A, Klein C, Goldstein R, Prokhorov T, Theitler J et al (2006) Excessive daytime sleepiness in patients with Parkinson’s disease: a polysomnography study. Mov Disord 21(9):1432–1438CrossRefPubMed
101.
Rodrigues TM, Castro Caldas A, Ferreira JJ (2016) Pharmacological interventions for daytime sleepiness and sleep disorders in Parkinson’s disease: systematic review and meta-analysis. Parkinsonism Relat Disord 27:25–34CrossRefPubMed
102.
Büchele F, Hackius M, Schreglmann SR, Omlor W, Werth E, Maric A et al (2018) Sodium oxybate for excessive daytime sleepiness and sleep disturbance in parkinson disease: a randomized clinical trial. JAMA Neurol. 75(1):114–118CrossRefPubMed
103.
104.
Friedman JH, Brown RG, Comella C, Garber CE, Krupp LB, Lou J-S et al (2007) Fatigue in Parkinson’s disease: a review. Mov Disord 22(3):297–308CrossRefPubMed
105.
Friedman JH (2016) Thoughts on fatigue in Parkinson’s disease (and other disorders). Eur J Neurol 4
106.
Siciliano M, Trojano L, Santangelo G, De Micco R, Tedeschi G, Tessitore A (2018) Fatigue in Parkinson’s disease: a systematic review and meta-analysis. Mov Disord 33(11):1712–1723CrossRefPubMed
107.
Chen MK (1986) The epidemiology of self-perceived fatigue among adults. Prev Med 15(1):74–81CrossRefPubMed
108.
Titova N, Qamar MA, Chaudhuri KR (2017) The nonmotor features of parkinson’s disease. Int Rev Neurobiol 132:33–54CrossRefPubMed
109.
Politis M, Niccolini F (2015) Serotonin in Parkinson’s disease. Behav Brain Res 277:136–145CrossRefPubMed
110.
111.
Maillet A, Krack P, Lhommée E, Météreau E, Klinger H, Favre E et al (2016) The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson’s disease. Brain. 139(Pt 9):2486–2502CrossRefPubMed
112.
Levy R, Dubois B (2006) Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits. Cereb Cortex 16(7):916–928CrossRefPubMed
113.
Valko PO, Waldvogel D, Weller M, Bassetti CL, Held U, Baumann CR (2010) Fatigue and excessive daytime sleepiness in idiopathic Parkinson’s disease differently correlate with motor symptoms, depression and dopaminergic treatment. Eur J Neurol 17(12):1428–1436CrossRefPubMed
114.
Romigi A, Franco V, Placidi F, Liguori C, Rastelli E, Vitrani G et al (2018) Comparative sleep disturbances in myotonic dystrophy types 1 and 2. Curr Neurol Neurosci Rep. 18(12):102CrossRefPubMed
115.
Rubinsztein JS, Rubinsztein DC, Goodburn S, Holland AJ (1998) Apathy and hypersomnia are common features of myotonic dystrophy. J Neurol Neurosurg Psychiatry 64(4):510–515CrossRefPubMedPubMedCentral
116.
Laberge L, Bégin P, Montplaisir J, Mathieu J (2004) Sleep complaints in patients with myotonic dystrophy. J Sleep Res 13(1):95–100CrossRefPubMed
117.
Laberge L, Dauvilliers Y, Bégin P, Richer L, Jean S, Mathieu J (2009a) Fatigue and daytime sleepiness in patients with myotonic dystrophy type 1: to lump or split? Neuromuscul Disord 19(6):397–402CrossRefPubMed
118.
Gallais B, Gagnon C, Forgues G, Côté I, Laberge L (2017) Further evidence for the reliability and validity of the Fatigue and Daytime Sleepiness Scale. J Neurol Sci 375:23–26CrossRefPubMed
119.
Heatwole C, Bode R, Johnson N, Quinn C, Martens W, McDermott MP et al (2012) Patient-reported impact of symptoms in myotonic dystrophy type 1 (PRISM-1). Neurology. 79(4):348–357CrossRefPubMedPubMedCentral
120.
Kalkman JS, Schillings ML, van der Werf SP, Padberg GW, Zwarts MJ, van Engelen BGM et al (2005) Experienced fatigue in facioscapulohumeral dystrophy, myotonic dystrophy, and HMSN-I. J Neurol Neurosurg Psychiatry 76(10):1406–1409CrossRefPubMedPubMedCentral
121.
Heatwole C, Johnson N, Bode R, Dekdebrun J, Dilek N, Hilbert JE et al (2015) Patient-reported impact of symptoms in myotonic dystrophy type 2 (PRISM-2). Neurology. 85(24):2136–2146CrossRefPubMedPubMedCentral
122.
Gagnon C, Mathieu J, Jean S, Laberge L, Perron M, Veillette S et al (2008) Predictors of disrupted social participation in myotonic dystrophy type 1. Arch Phys Med Rehabil 89(7):1246–1255CrossRefPubMed
123.
Laberge L, Mathieu J, Auclair J, Gagnon É, Noreau L, Gagnon C (2013) Clinical, psychosocial, and central correlates of quality of life in myotonic dystrophy type 1 patients. Eur Neurol 70(5–6):308–315CrossRefPubMed
124.
Laberge L, Dauvilliers Y (2011) Myotonic dystrophy and sleepiness. In: Thorpy MJ, Billiard M (eds) Sleepiness: causes, consequences and treatment. Cambridge University Press, Cambridge, pp 316–328CrossRef
125.
Yu H, Laberge L, Jaussent I, Bayard S, Scholtz S, Raoul M et al (2011) Daytime sleepiness and REM sleep characteristics in myotonic dystrophy: a case-control study. Sleep. 34(2):165–170CrossRefPubMedPubMedCentral
126.
Laberge L, Bégin P, Dauvilliers Y, Beaudry M, Laforte M, Jean S et al (2009b) A polysomnographic study of daytime sleepiness in myotonic dystrophy type 1. J Neurol Neurosurg Psychiatry 80(6):642–646CrossRefPubMed
127.
van der Meché FG, Bogaard JM, van der Sluys JC, Schimsheimer RJ, Ververs CC, Busch HF (1994) Daytime sleep in myotonic dystrophy is not caused by sleep apnoea. J Neurol Neurosurg Psychiatry 57(5):626–628CrossRefPubMedPubMedCentral
128.
Gibbs JW, Ciafaloni E, Radtke RA (2002) Excessive daytime somnolence and increased rapid eye movement pressure in myotonic dystrophy. Sleep. 25(6):662–665CrossRefPubMed
129.
Romigi A, Albanese M, Liguori C, Placidi F, Marciani MG, Massa R (2013) Sleep-wake cycle and daytime sleepiness in the myotonic dystrophies. J Neurodegener Dis 2013:692026PubMedPubMedCentral
130.
Cirignotta F, Mondini S, Zucconi M, Barrot-Cortes E, Sturani C, Schiavina M et al (1987) Sleep-related breathing impairment in myotonic dystrophy. J Neurol 235(2):80–85CrossRefPubMed
131.
Kiyan E, Okumus G, Cuhadaroglu C, Deymeer F (2010) Sleep apnea in adult myotonic dystrophy patients who have no excessive daytime sleepiness. Sleep Breath 14(1):19–24CrossRefPubMed
132.
Gilmartin JJ, Cooper BG, Griffiths CJ, Walls TJ, Veale D, Stone TN et al (1991) Breathing during sleep in patients with myotonic dystrophy and non-myotonic respiratory muscle weakness. Q J Med 78(285):21–31PubMed
133.
Phillips MF, Steer HM, Soldan JR, Wiles CM, Harper PS (1999) Daytime somnolence in myotonic dystrophy. J Neurol 246(4):275–282CrossRefPubMed
134.
Romigi A, Maestri M, Nicoletta C, Vitrani G, Caccamo M, Siciliano G et al (2019) Sleep complaints, sleep and breathing disorders in myotonic dystrophy type 2. Curr Neurol Neurosci Rep 9
135.
Dauvilliers YA, Laberge L (2012) Myotonic dystrophy type 1, daytime sleepiness and REM sleep dysregulation. Sleep Med Rev 16(6):539–545CrossRefPubMed
136.
Bonanni E, Carnicelli L, Crapanzano D, Maestri M, Simoncini C, Baldanzi S et al (2018) Disruption of sleep-wake continuum in myotonic dystrophy type 1: beyond conventional sleep staging. Neuromuscul Disord 28(5):414–421CrossRefPubMed
137.
West SD, Lochmüller H, Hughes J, Atalaia A, Marini-Bettolo C, Baudouin SV et al (2016) Sleepiness and sleep-related breathing disorders in myotonic dystrophy and responses to treatment: a prospective cohort study. J Neuromuscul Dis 3(4):529–537CrossRefPubMed
138.
Popp RFJ, Fierlbeck AK, Knüttel H, König N, Rupprecht R, Weissert R et al (2017) Daytime sleepiness versus fatigue in patients with multiple sclerosis: a systematic review on the Epworth sleepiness scale as an assessment tool. Sleep Med Rev 32:95–108CrossRefPubMed
139.
Iriarte J, Subirá ML, Castro P (2000) Modalities of fatigue in multiple sclerosis: correlation with clinical and biological factors. Mult Scler 6(2):124–130CrossRefPubMed
140.
Colosimo C, Millefiorini E, Grasso MG, Vinci F, Fiorelli M, Koudriavtseva T et al (2009) Fatigue in MS is associated with specific clinical features. Acta Neurol Scand 92(5):353–355CrossRef
141.
Krupp LB, Pollina DA (1996) Mechanisms and management of fatigue in progressive neurological disorders. Curr Opin Neurol 9(6):456–460CrossRefPubMed
142.
Vercoulen JHMM (1996) The measurement of fatigue in patients with multiple sclerosis. Arch Neurol 53(7):642CrossRefPubMed
143.
Freal JE, Kraft GH, Coryell JK (1984) Symptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil 65(3):135–138PubMed
144.
Krupp LB, Alvarez LA, LaRocca NG, Scheinberg LC (1988) Fatigue in multiple sclerosis. Arch Neurol 45(4):435–437CrossRefPubMed
145.
Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD (1989) The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 46(10):1121–1123CrossRefPubMed
146.
147.
Brass SD, Li C-S, Auerbach S (2014) The underdiagnosis of sleep disorders in patients with multiple sclerosis. J Clin Sleep Med 10(9):1025–1031CrossRefPubMedPubMedCentral
148.
Neau J-P, Paquereau J, Auche V, Mathis S, Godeneche G, Ciron J et al (2012) Sleep disorders and multiple sclerosis: a clinical and polysomnography study. Eur Neurol 68(1):8–15CrossRefPubMed
149.
Kaminska M, Kimoff RJ, Benedetti A, Robinson A, Bar-Or A, Lapierre Y et al (2012) Obstructive sleep apnea is associated with fatigue in multiple sclerosis. Mult Scler 18(8):1159–1169CrossRefPubMed
150.
Chen J-H, Liu X-Q, Sun H-Y, Huang Y (2014) Sleep disorders in multiple sclerosis in China: clinical, polysomnography study, and review of the literature. J Clin Neurophysiol 31(4):375–381CrossRefPubMed
151.
Sater RA, Gudesblatt M, Kresa-Reahl K, Brandes DW, Sater PA (2015) The relationship between objective parameters of sleep and measures of fatigue, depression, and cognition in multiple sclerosis. Mult Scler J Exp Transl Clin 1:2055217315577828PubMedPubMedCentral
152.
Côté I, Trojan DA, Kaminska M, Cardoso M, Benedetti A, Weiss D et al (2013) Impact of sleep disorder treatment on fatigue in multiple sclerosis. Mult Scler 19(4):480–489CrossRefPubMed
153.
Veauthier C, Radbruch H, Gaede G, Pfueller CF, Dörr J, Bellmann-Strobl J et al (2011) Fatigue in multiple sclerosis is closely related to sleep disorders: a polysomnographic cross-sectional study. Mult Scler 17(5):613–622CrossRefPubMed
154.
Ferini-Strambi L, Filippi M, Martinelli V, Oldani A, Rovaris M, Zucconi M et al (1994) Nocturnal sleep study in multiple sclerosis: correlations with clinical and brain magnetic resonance imaging findings. J Neurol Sci 125(2):194–197CrossRefPubMed
155.
Kaynak H, Altintaş A, Kaynak D, Uyanik O, Saip S, Ağaoğlu J et al (2006) Fatigue and sleep disturbance in multiple sclerosis. Eur J Neurol 13(12):1333–1339CrossRefPubMed
156.
Hensen HA, Krishnan AV, Eckert DJ (2017) Sleep-disordered breathing in people with multiple sclerosis: prevalence, pathophysiological mechanisms, and disease consequences. Front Neurol 8:740CrossRefPubMed
157.
158.
Čarnická Z, Kollár B, Šiarnik P, Krížová L, Klobučníková K, Turčáni P (2015) Sleep disorders in patients with multiple sclerosis. J Clin Sleep Med 11(5):553–557CrossRefPubMedPubMedCentral
159.
Kallweit U, Baumann CR, Harzheim M, Hidalgo H, Pöhlau D, Bassetti CL et al (2013) Fatigue and sleep-disordered breathing in multiple sclerosis: a clinically relevant association? Mult Scler Int 2013:286581PubMedPubMedCentral
160.
Lin M, Krishnan AV, Eckert DJ (2017) Central sleep apnea in multiple sclerosis: a pilot study. Sleep Breath 21(3):691–696CrossRefPubMed
161.
Tachibana N, Howard RS, Hirsch NP, Miller DH, Moseley IF, Fish D (1994) Sleep problems in multiple sclerosis. Eur Neurol 34(6):320–323CrossRefPubMed
162.
Vetrugno R, Stecchi S, Scandellari C, Pierangeli G, Sabattini L, D’Angelo R et al (2007) Sleep--wake and body core temperature rhythms in multiple sclerosis with fatigue. Clin Neurophysiol 118(1):228–234CrossRefPubMed
163.
164.
Veauthier C, Gaede G, Radbruch H, Gottschalk S, Wernecke K-D, Paul F (2013) Treatment of sleep disorders may improve fatigue in multiple sclerosis. Clin Neurol Neurosurg 115(9):1826–1830CrossRefPubMed
165.
166.
Deriu M, Cossu G, Molari A, Murgia D, Mereu A, Ferrigno P et al (2009) Restless legs syndrome in multiple sclerosis: a case-control study. Mov Disord 24(5):697–701CrossRefPubMed
167.
Italian REMS Study Group, Manconi M, Ferini-Strambi L, Filippi M, Bonanni E, Iudice A et al (2008) Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS study. Sleep. 31(7):944–952CrossRef
168.
Manconi M, Fabbrini M, Bonanni E, Filippi M, Rocca M, Murri L et al (2007) High prevalence of restless legs syndrome in multiple sclerosis. Eur J Neurol 14(5):534–539CrossRefPubMed
169.
Manconi M, Rocca MA, Ferini-Strambi L, Tortorella P, Agosta F, Comi G et al (2008) Restless legs syndrome is a common finding in multiple sclerosis and correlates with cervical cord damage. Mult Scler 14(1):86–93CrossRefPubMed
170.
Auger C, Montplaisir J, Duquette P (2005) Increased frequency of restless legs syndrome in a French-Canadian population with multiple sclerosis. Neurology. 65(10):1652–1653CrossRefPubMed
Metadaten
Titel
Excessive daytime sleepiness and fatigue in neurological disorders
verfasst von
Michelangelo Maestri
Andrea Romigi
Alessandro Schirru
Monica Fabbrini
Sara Gori
Ubaldo Bonuccelli
Enrica Bonanni
Publikationsdatum
23.08.2019
Verlag
Springer International Publishing
Erschienen in
Sleep and Breathing / Ausgabe 2/2020
Print ISSN: 1520-9512
Elektronische ISSN: 1522-1709
DOI
https://doi.org/10.1007/s11325-019-01921-4

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