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Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 12/2018

01.12.2018 | Sleep (M Thorpy and M Billiard, Section Editors)

Comparative Sleep Disturbances in Myotonic Dystrophy Types 1 and 2

verfasst von: Andrea Romigi, Valentina Franco, Fabio Placidi, Claudio Liguori, Emanuele Rastelli, Giuseppe Vitrani, Diego Centonze, Roberto Massa

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 12/2018

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Abstract

Purpose of Review

To update current knowledge regarding sleep disturbances and myotonic dystrophies so as to better understand if sleep symptoms may help in the early recognition of the two genetic subtypes: myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2).

Recent Findings

Sleep-disordered breathing (SDB), restless legs syndrome, periodic limb movements in sleep, hypersomnia, and REM sleep dysregulation are frequently described in DM1 patients. SDB does not always explain hypersomnia, but a central dysregulation of sleep–wake modulation is reported mainly in DM1. Sleep apnea, restless legs syndrome, and REM sleep without atonia have been reported in single case reports and small case series of DM2.

Summary

DM2 is less prevalent and more recently described than DM1, with a milder phenotype than DM1. The most frequent sleep disorders in DM1 are hypersomnia, SDB, periodic limb movements, and a narcoleptic-like phenotype, whereas restless legs syndrome, SDB, and REM sleep without atonia seem to be the most frequent sleep disorders in DM2. Comparative sleep studies are strongly required to delineate the sleep phenotype of myotonic dystrophies.
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Metadaten
Titel
Comparative Sleep Disturbances in Myotonic Dystrophy Types 1 and 2
verfasst von
Andrea Romigi
Valentina Franco
Fabio Placidi
Claudio Liguori
Emanuele Rastelli
Giuseppe Vitrani
Diego Centonze
Roberto Massa
Publikationsdatum
01.12.2018
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 12/2018
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-018-0903-x

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