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Brain Structure and Function

Erschienen in:

05.02.2021 | Review

Exploring the secrets of brain transcriptional regulation: developing methodologies, recent significant findings, and perspectives

verfasst von: Zhe Ding, Luyun Sun, Cen Yang, Aihua Liu, Fukai Bao

Erschienen in: Brain Structure and Function | Ausgabe 2/2021

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Abstract

Exploring and revealing the secret of the function of the human brain has been the dream of mankind and science. Delineating brain transcriptional regulation has been extremely challenging, but recent technological advances have facilitated a deeper investigation of molecular processes in the brain. Tracing the molecular regulatory mechanisms of different gene expression profiles in the brain is divergent and has made it possible to connect spatial and temporal variations in gene expression to distributed properties of brain structure and function. Here, we review the molecular diversity of the brain among rodents, non-human primates and humans. We also discuss the molecular mechanism of non-coding DNA/RNA at the transcriptional/post-transcriptional level based on recent technical advances to highlight an improved understanding of the complex transcriptional network in the brain. Spatiotemporal and single-cell transcriptomics have attempted to gain novel insight into the development and evolution of the brain as well as the progression of human diseases. Although it is clear that the field is developing and challenges remain to be resolved, the impressive recent progress provides a solid foundation to better understand the brain and evidence-based recommendations for the diagnosis and treatment of brain diseases.

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Titel: Exploring the secrets of brain transcriptional regulation: developing methodologies, recent significant findings, and perspectives
verfasst von: Zhe Ding
Luyun Sun
Cen Yang
Aihua Liu
Fukai Bao
Publikationsdatum: 05.02.2021
Verlag: Springer Berlin Heidelberg
Erschienen in: Brain Structure and Function / Ausgabe 2/2021
Print ISSN: 1863-2653
Elektronische ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-021-02230-x

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